Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19
We conducted a prospective cohort study at a community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate the relationship of viral shedding with symptom changes of COVID-19. In total, 89 COVID-19 adult patie...
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2021
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oai:doaj.org-article:41e2ae6edfe34f8fa0f894a5fff23c3c2021-11-25T19:12:34ZDynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-1910.3390/v131121331999-4915https://doaj.org/article/41e2ae6edfe34f8fa0f894a5fff23c3c2021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2133https://doaj.org/toc/1999-4915We conducted a prospective cohort study at a community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate the relationship of viral shedding with symptom changes of COVID-19. In total, 89 COVID-19 adult patients (12 asymptomatic, 16 presymptomatic, 61 symptomatic) were enrolled. Symptom scores, the genomic RNA and subgenomic RNA of SARS-CoV-2 from saliva samples with a cell culture were measured. Asymptomatic COVID-19 patients had a similar viral load to symptomatic patients during the early course of the disease, but exhibited a rapid decrease in viral load with the loss of infectivity. Subgenomic RNA and viable virus by cell culture in asymptomatic patients were detected only until 3 days after diagnosis, and the positivity of the subgenomic RNA and cell culture in symptomatic patients gradually decreased in both from 40% in the early disease course to 13% at 10 days and 4% at 8 days after the symptom onset, respectively. In conclusion, symptomatic patients have a high infectivity with high symptom scores during the early disease course and gradually lose infectivity depending on the symptom. Conversely, asymptomatic patients exhibit a rapid decrease in viral load with the loss of infectivity, despite a similar viral load during the early disease course.Seongman BaeJi Yeun KimSo Yun LimHeedo ParkHye Hee ChaJi-Soo KwonMi Hyun SuhHyun Jung LeeJoon Seo LimJiwon JungMin Jae KimYong Pil ChongSang-Oh LeeSang-Ho ChoiYang Soo KimHo Young LeeSohyun LeeMan-Seong ParkSung-Han KimMDPI AGarticleSARS-CoV-2presymptomaticviral sheddingsubgenomic RNAviable cultureMicrobiologyQR1-502ENViruses, Vol 13, Iss 2133, p 2133 (2021) |
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SARS-CoV-2 presymptomatic viral shedding subgenomic RNA viable culture Microbiology QR1-502 |
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SARS-CoV-2 presymptomatic viral shedding subgenomic RNA viable culture Microbiology QR1-502 Seongman Bae Ji Yeun Kim So Yun Lim Heedo Park Hye Hee Cha Ji-Soo Kwon Mi Hyun Suh Hyun Jung Lee Joon Seo Lim Jiwon Jung Min Jae Kim Yong Pil Chong Sang-Oh Lee Sang-Ho Choi Yang Soo Kim Ho Young Lee Sohyun Lee Man-Seong Park Sung-Han Kim Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 |
| description |
We conducted a prospective cohort study at a community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate the relationship of viral shedding with symptom changes of COVID-19. In total, 89 COVID-19 adult patients (12 asymptomatic, 16 presymptomatic, 61 symptomatic) were enrolled. Symptom scores, the genomic RNA and subgenomic RNA of SARS-CoV-2 from saliva samples with a cell culture were measured. Asymptomatic COVID-19 patients had a similar viral load to symptomatic patients during the early course of the disease, but exhibited a rapid decrease in viral load with the loss of infectivity. Subgenomic RNA and viable virus by cell culture in asymptomatic patients were detected only until 3 days after diagnosis, and the positivity of the subgenomic RNA and cell culture in symptomatic patients gradually decreased in both from 40% in the early disease course to 13% at 10 days and 4% at 8 days after the symptom onset, respectively. In conclusion, symptomatic patients have a high infectivity with high symptom scores during the early disease course and gradually lose infectivity depending on the symptom. Conversely, asymptomatic patients exhibit a rapid decrease in viral load with the loss of infectivity, despite a similar viral load during the early disease course. |
| format |
article |
| author |
Seongman Bae Ji Yeun Kim So Yun Lim Heedo Park Hye Hee Cha Ji-Soo Kwon Mi Hyun Suh Hyun Jung Lee Joon Seo Lim Jiwon Jung Min Jae Kim Yong Pil Chong Sang-Oh Lee Sang-Ho Choi Yang Soo Kim Ho Young Lee Sohyun Lee Man-Seong Park Sung-Han Kim |
| author_facet |
Seongman Bae Ji Yeun Kim So Yun Lim Heedo Park Hye Hee Cha Ji-Soo Kwon Mi Hyun Suh Hyun Jung Lee Joon Seo Lim Jiwon Jung Min Jae Kim Yong Pil Chong Sang-Oh Lee Sang-Ho Choi Yang Soo Kim Ho Young Lee Sohyun Lee Man-Seong Park Sung-Han Kim |
| author_sort |
Seongman Bae |
| title |
Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 |
| title_short |
Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 |
| title_full |
Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 |
| title_fullStr |
Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 |
| title_full_unstemmed |
Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 |
| title_sort |
dynamics of viral shedding and symptoms in patients with asymptomatic or mild covid-19 |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/41e2ae6edfe34f8fa0f894a5fff23c3c |
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