ACTOPROTECTIVE ACTIVITY OF THE COMPLEX PLANT REMEDY

Background. Intensive physical exertion is one of the stress-factors leading to the decrease of non-specific resistance of the body, significant increase in oxygen consumption followed by activation of the lipid peroxidation and decrease of endogenic antioxidant system efficacy.The aim of the pres...

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Autores principales:	B. A. Muruev, A. G. Mondodoev, I. E. Matkhanov, A. A. Toropova, L. N. Shantanova, O. G. Dimitrov, O. V. Yundunova, I. S. Butukhanova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	actoprotective activity physical exertion oxidative stress adaptogens energy-protecting influence Science Q
Acceso en línea:	https://doaj.org/article/41e3170ff44446b08190e370fbf7f5c4
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spelling	oai:doaj.org-article:41e3170ff44446b08190e370fbf7f5c42021-11-23T06:14:40ZACTOPROTECTIVE ACTIVITY OF THE COMPLEX PLANT REMEDY2541-94202587-959610.29413/ABS.2018-3.4.17https://doaj.org/article/41e3170ff44446b08190e370fbf7f5c42018-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/658https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Intensive physical exertion is one of the stress-factors leading to the decrease of non-specific resistance of the body, significant increase in oxygen consumption followed by activation of the lipid peroxidation and decrease of endogenic antioxidant system efficacy.The aim of the present study was to evaluate the influence of the complex plant remedy on exercise tolerance of laboratory animals and to reveal mechanisms increasing physical endurance.Materials and methods. The experiments were carried out on white Wistar rats weighing 190-220 g. The physical endurance of the animals was estimated by recording time of weighted swimming to complete exhaustion in the pool. The weighting was 7 % of the body mass. The water solution of the dry extract derived from five medicinal plants was introduced intragastrically to the animals of the experimental group at the dose of 100 mg/kg in the volume of 10 ml/kg for 7 days (once a day), an hour before testing. The content of ATP, lactic acid and pyruvic acid were determined in the skeletal muscle homogenate; glycogen was determined in the liver homogenate; in the blood serum there was estimated concentration of malonic dialdehyde, the activity of catalase; the concentration of reduced glutathione was determined in the whole blood and the activity of superoxide dismutase was estimated in erythrocytes.Conclusion. The course introduction of the complex plant remedy to rats results in resilience to intensive physical exertion due to optimization of energy metabolism, inhibition of free-radical biomacromolecule oxidation processes and increase in endogenic antioxidant system activity.B. A. MuruevA. G. MondodoevI. E. MatkhanovA. A. ToropovaL. N. ShantanovaO. G. DimitrovO. V. YundunovaI. S. ButukhanovaScientific Сentre for Family Health and Human Reproduction Problemsarticleactoprotective activityphysical exertionoxidative stressadaptogensenergy-protecting influenceScienceQRUActa Biomedica Scientifica, Vol 3, Iss 4, Pp 120-124 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	actoprotective activity physical exertion oxidative stress adaptogens energy-protecting influence Science Q
spellingShingle	actoprotective activity physical exertion oxidative stress adaptogens energy-protecting influence Science Q B. A. Muruev A. G. Mondodoev I. E. Matkhanov A. A. Toropova L. N. Shantanova O. G. Dimitrov O. V. Yundunova I. S. Butukhanova ACTOPROTECTIVE ACTIVITY OF THE COMPLEX PLANT REMEDY
description	Background. Intensive physical exertion is one of the stress-factors leading to the decrease of non-specific resistance of the body, significant increase in oxygen consumption followed by activation of the lipid peroxidation and decrease of endogenic antioxidant system efficacy.The aim of the present study was to evaluate the influence of the complex plant remedy on exercise tolerance of laboratory animals and to reveal mechanisms increasing physical endurance.Materials and methods. The experiments were carried out on white Wistar rats weighing 190-220 g. The physical endurance of the animals was estimated by recording time of weighted swimming to complete exhaustion in the pool. The weighting was 7 % of the body mass. The water solution of the dry extract derived from five medicinal plants was introduced intragastrically to the animals of the experimental group at the dose of 100 mg/kg in the volume of 10 ml/kg for 7 days (once a day), an hour before testing. The content of ATP, lactic acid and pyruvic acid were determined in the skeletal muscle homogenate; glycogen was determined in the liver homogenate; in the blood serum there was estimated concentration of malonic dialdehyde, the activity of catalase; the concentration of reduced glutathione was determined in the whole blood and the activity of superoxide dismutase was estimated in erythrocytes.Conclusion. The course introduction of the complex plant remedy to rats results in resilience to intensive physical exertion due to optimization of energy metabolism, inhibition of free-radical biomacromolecule oxidation processes and increase in endogenic antioxidant system activity.
format	article
author	B. A. Muruev A. G. Mondodoev I. E. Matkhanov A. A. Toropova L. N. Shantanova O. G. Dimitrov O. V. Yundunova I. S. Butukhanova
author_facet	B. A. Muruev A. G. Mondodoev I. E. Matkhanov A. A. Toropova L. N. Shantanova O. G. Dimitrov O. V. Yundunova I. S. Butukhanova
author_sort	B. A. Muruev
title	ACTOPROTECTIVE ACTIVITY OF THE COMPLEX PLANT REMEDY
title_short	ACTOPROTECTIVE ACTIVITY OF THE COMPLEX PLANT REMEDY
title_full	ACTOPROTECTIVE ACTIVITY OF THE COMPLEX PLANT REMEDY
title_fullStr	ACTOPROTECTIVE ACTIVITY OF THE COMPLEX PLANT REMEDY
title_full_unstemmed	ACTOPROTECTIVE ACTIVITY OF THE COMPLEX PLANT REMEDY
title_sort	actoprotective activity of the complex plant remedy
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/41e3170ff44446b08190e370fbf7f5c4
work_keys_str_mv	AT bamuruev actoprotectiveactivityofthecomplexplantremedy AT agmondodoev actoprotectiveactivityofthecomplexplantremedy AT iematkhanov actoprotectiveactivityofthecomplexplantremedy AT aatoropova actoprotectiveactivityofthecomplexplantremedy AT lnshantanova actoprotectiveactivityofthecomplexplantremedy AT ogdimitrov actoprotectiveactivityofthecomplexplantremedy AT ovyundunova actoprotectiveactivityofthecomplexplantremedy AT isbutukhanova actoprotectiveactivityofthecomplexplantremedy
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ACTOPROTECTIVE ACTIVITY OF THE COMPLEX PLANT REMEDY

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