Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cDC2 come from multiple origins, but converge functi...

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Autores principales:	Nikos E. Papaioannou, Natallia Salei, Stephan Rambichler, Kaushikk Ravi, Jelena Popovic, Vanessa Küntzel, Christian H. K. Lehmann, Remi Fiancette, Johanna Salvermoser, Dominika W. Gajdasik, Ramona Mettler, Denise Messerer, Joana Carrelha, Caspar Ohnmacht, Dirk Haller, Ralf Stumm, Tobias Straub, Sten Eirik W. Jacobsen, Christian Schulz, David R. Withers, Gunnar Schotta, Diana Dudziak, Barbara U. Schraml
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41e3849697dd487fb5c3e7640b8e444b
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spelling	oai:doaj.org-article:41e3849697dd487fb5c3e7640b8e444b2021-12-02T10:49:08ZEnvironmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice10.1038/s41467-020-20659-22041-1723https://doaj.org/article/41e3849697dd487fb5c3e7640b8e444b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20659-2https://doaj.org/toc/2041-1723Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cDC2 come from multiple origins, but converge functionally as potent immune activators upon proper stimuli.Nikos E. PapaioannouNatallia SaleiStephan RambichlerKaushikk RaviJelena PopovicVanessa KüntzelChristian H. K. LehmannRemi FiancetteJohanna SalvermoserDominika W. GajdasikRamona MettlerDenise MessererJoana CarrelhaCaspar OhnmachtDirk HallerRalf StummTobias StraubSten Eirik W. JacobsenChristian SchulzDavid R. WithersGunnar SchottaDiana DudziakBarbara U. SchramlNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nikos E. Papaioannou Natallia Salei Stephan Rambichler Kaushikk Ravi Jelena Popovic Vanessa Küntzel Christian H. K. Lehmann Remi Fiancette Johanna Salvermoser Dominika W. Gajdasik Ramona Mettler Denise Messerer Joana Carrelha Caspar Ohnmacht Dirk Haller Ralf Stumm Tobias Straub Sten Eirik W. Jacobsen Christian Schulz David R. Withers Gunnar Schotta Diana Dudziak Barbara U. Schraml Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice
description	Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cDC2 come from multiple origins, but converge functionally as potent immune activators upon proper stimuli.
format	article
author	Nikos E. Papaioannou Natallia Salei Stephan Rambichler Kaushikk Ravi Jelena Popovic Vanessa Küntzel Christian H. K. Lehmann Remi Fiancette Johanna Salvermoser Dominika W. Gajdasik Ramona Mettler Denise Messerer Joana Carrelha Caspar Ohnmacht Dirk Haller Ralf Stumm Tobias Straub Sten Eirik W. Jacobsen Christian Schulz David R. Withers Gunnar Schotta Diana Dudziak Barbara U. Schraml
author_facet	Nikos E. Papaioannou Natallia Salei Stephan Rambichler Kaushikk Ravi Jelena Popovic Vanessa Küntzel Christian H. K. Lehmann Remi Fiancette Johanna Salvermoser Dominika W. Gajdasik Ramona Mettler Denise Messerer Joana Carrelha Caspar Ohnmacht Dirk Haller Ralf Stumm Tobias Straub Sten Eirik W. Jacobsen Christian Schulz David R. Withers Gunnar Schotta Diana Dudziak Barbara U. Schraml
author_sort	Nikos E. Papaioannou
title	Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice
title_short	Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice
title_full	Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice
title_fullStr	Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice
title_full_unstemmed	Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice
title_sort	environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/41e3849697dd487fb5c3e7640b8e444b
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Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

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