Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum

Neurodegenerative lesions induce sprouting from surviving axons, but the patterns of re-innervation of these collaterals in relation to existing functional networks remains unclear. Here the authors performed long term in vivoimaging in mice, of sprouts from cerebellar climbing fibers after a lesion...

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Autores principales:	Matasha Dhar, Joshua M. Brenner, Kenji Sakimura, Masanobu Kano, Hiroshi Nishiyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41e4009724e94b1894d6ea1d6604f795
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spelling	oai:doaj.org-article:41e4009724e94b1894d6ea1d6604f7952021-12-02T17:32:50ZSpatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum10.1038/ncomms129382041-1723https://doaj.org/article/41e4009724e94b1894d6ea1d6604f7952016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12938https://doaj.org/toc/2041-1723Neurodegenerative lesions induce sprouting from surviving axons, but the patterns of re-innervation of these collaterals in relation to existing functional networks remains unclear. Here the authors performed long term in vivoimaging in mice, of sprouts from cerebellar climbing fibers after a lesion, and describe the patterns of connectivity relative to functionally active zones.Matasha DharJoshua M. BrennerKenji SakimuraMasanobu KanoHiroshi NishiyamaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matasha Dhar Joshua M. Brenner Kenji Sakimura Masanobu Kano Hiroshi Nishiyama Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum
description	Neurodegenerative lesions induce sprouting from surviving axons, but the patterns of re-innervation of these collaterals in relation to existing functional networks remains unclear. Here the authors performed long term in vivoimaging in mice, of sprouts from cerebellar climbing fibers after a lesion, and describe the patterns of connectivity relative to functionally active zones.
format	article
author	Matasha Dhar Joshua M. Brenner Kenji Sakimura Masanobu Kano Hiroshi Nishiyama
author_facet	Matasha Dhar Joshua M. Brenner Kenji Sakimura Masanobu Kano Hiroshi Nishiyama
author_sort	Matasha Dhar
title	Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum
title_short	Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum
title_full	Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum
title_fullStr	Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum
title_full_unstemmed	Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum
title_sort	spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/41e4009724e94b1894d6ea1d6604f795
work_keys_str_mv	AT matashadhar spatiotemporaldynamicsoflesioninducedaxonalsproutinganditsrelationtofunctionalarchitectureofthecerebellum AT joshuambrenner spatiotemporaldynamicsoflesioninducedaxonalsproutinganditsrelationtofunctionalarchitectureofthecerebellum AT kenjisakimura spatiotemporaldynamicsoflesioninducedaxonalsproutinganditsrelationtofunctionalarchitectureofthecerebellum AT masanobukano spatiotemporaldynamicsoflesioninducedaxonalsproutinganditsrelationtofunctionalarchitectureofthecerebellum AT hiroshinishiyama spatiotemporaldynamicsoflesioninducedaxonalsproutinganditsrelationtofunctionalarchitectureofthecerebellum
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Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum

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