Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice
Abstract Recently, food-based bioactive ingredients, such as vinegar, have been proposed as a potential solution to overcome the global obesity epidemic. Although acetic acid has been identified as the main component in vinegar that contributes to its anti-obesity effect, reports have shown that vin...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/41e535e637384c18a98e515010365f70 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:41e535e637384c18a98e515010365f70 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:41e535e637384c18a98e515010365f702021-12-02T11:53:02ZAnti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice10.1038/s41598-017-06235-72045-2322https://doaj.org/article/41e535e637384c18a98e515010365f702017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06235-7https://doaj.org/toc/2045-2322Abstract Recently, food-based bioactive ingredients, such as vinegar, have been proposed as a potential solution to overcome the global obesity epidemic. Although acetic acid has been identified as the main component in vinegar that contributes to its anti-obesity effect, reports have shown that vinegar produced from different starting materials possess different degrees of bioactivity. This study was performed to compare the anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar in mice fed a high-fat diet. In this work, mice were fed a high-fat diet for 33 weeks. At the start of week 24, obese mice were orally fed synthetic acetic acid vinegar or Nipa vinegar (0.08 and 2 ml/kg BW) until the end of week 33. Mice fed a standard pellet diet served as a control. Although both synthetic acetic acid vinegar and Nipa vinegar effectively reduced food intake and body weight, a high dose of Nipa vinegar more effectively reduced lipid deposition, improved the serum lipid profile, increased adipokine expression and suppressed inflammation in the obese mice. Thus, a high dose of Nipa vinegar may potentially alleviate obesity by altering the lipid metabolism, inflammation and gut microbe composition in high-fat-diet-induced obese mice.Boon Kee BehNurul Elyani MohamadSwee Keong YeapHuynh KySook Yee BooJoelle Yi Heng ChuaSheau Wei TanWan Yong HoShaiful Adzni SharifuddinKamariah LongNoorjahan Banu AlitheenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Boon Kee Beh Nurul Elyani Mohamad Swee Keong Yeap Huynh Ky Sook Yee Boo Joelle Yi Heng Chua Sheau Wei Tan Wan Yong Ho Shaiful Adzni Sharifuddin Kamariah Long Noorjahan Banu Alitheen Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice |
| description |
Abstract Recently, food-based bioactive ingredients, such as vinegar, have been proposed as a potential solution to overcome the global obesity epidemic. Although acetic acid has been identified as the main component in vinegar that contributes to its anti-obesity effect, reports have shown that vinegar produced from different starting materials possess different degrees of bioactivity. This study was performed to compare the anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar in mice fed a high-fat diet. In this work, mice were fed a high-fat diet for 33 weeks. At the start of week 24, obese mice were orally fed synthetic acetic acid vinegar or Nipa vinegar (0.08 and 2 ml/kg BW) until the end of week 33. Mice fed a standard pellet diet served as a control. Although both synthetic acetic acid vinegar and Nipa vinegar effectively reduced food intake and body weight, a high dose of Nipa vinegar more effectively reduced lipid deposition, improved the serum lipid profile, increased adipokine expression and suppressed inflammation in the obese mice. Thus, a high dose of Nipa vinegar may potentially alleviate obesity by altering the lipid metabolism, inflammation and gut microbe composition in high-fat-diet-induced obese mice. |
| format |
article |
| author |
Boon Kee Beh Nurul Elyani Mohamad Swee Keong Yeap Huynh Ky Sook Yee Boo Joelle Yi Heng Chua Sheau Wei Tan Wan Yong Ho Shaiful Adzni Sharifuddin Kamariah Long Noorjahan Banu Alitheen |
| author_facet |
Boon Kee Beh Nurul Elyani Mohamad Swee Keong Yeap Huynh Ky Sook Yee Boo Joelle Yi Heng Chua Sheau Wei Tan Wan Yong Ho Shaiful Adzni Sharifuddin Kamariah Long Noorjahan Banu Alitheen |
| author_sort |
Boon Kee Beh |
| title |
Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice |
| title_short |
Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice |
| title_full |
Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice |
| title_fullStr |
Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice |
| title_full_unstemmed |
Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice |
| title_sort |
anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and nipa vinegar on high-fat-diet-induced obese mice |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/41e535e637384c18a98e515010365f70 |
| work_keys_str_mv |
AT boonkeebeh antiobesityandantiinflammatoryeffectsofsyntheticaceticacidvinegarandnipavinegaronhighfatdietinducedobesemice AT nurulelyanimohamad antiobesityandantiinflammatoryeffectsofsyntheticaceticacidvinegarandnipavinegaronhighfatdietinducedobesemice AT sweekeongyeap antiobesityandantiinflammatoryeffectsofsyntheticaceticacidvinegarandnipavinegaronhighfatdietinducedobesemice AT huynhky antiobesityandantiinflammatoryeffectsofsyntheticaceticacidvinegarandnipavinegaronhighfatdietinducedobesemice AT sookyeeboo antiobesityandantiinflammatoryeffectsofsyntheticaceticacidvinegarandnipavinegaronhighfatdietinducedobesemice AT joelleyihengchua antiobesityandantiinflammatoryeffectsofsyntheticaceticacidvinegarandnipavinegaronhighfatdietinducedobesemice AT sheauweitan antiobesityandantiinflammatoryeffectsofsyntheticaceticacidvinegarandnipavinegaronhighfatdietinducedobesemice AT wanyongho antiobesityandantiinflammatoryeffectsofsyntheticaceticacidvinegarandnipavinegaronhighfatdietinducedobesemice AT shaifuladznisharifuddin antiobesityandantiinflammatoryeffectsofsyntheticaceticacidvinegarandnipavinegaronhighfatdietinducedobesemice AT kamariahlong antiobesityandantiinflammatoryeffectsofsyntheticaceticacidvinegarandnipavinegaronhighfatdietinducedobesemice AT noorjahanbanualitheen antiobesityandantiinflammatoryeffectsofsyntheticaceticacidvinegarandnipavinegaronhighfatdietinducedobesemice |
| _version_ |
1718394918730203136 |