Naringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation

Abstract Glucosamine-6-Phosphate synthase enzyme has been targeted for development of better and safe preservative due to its role in microbial cell wall synthesis. In recent year’s demand of preservatives for the food, cosmetics and pharmaceuticals have increased. Although, the available synthetic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amit Lather, Sunil Sharma, Anurag Khatkar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41e649e2638a42c8b3b5d343a180883a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:41e649e2638a42c8b3b5d343a180883a
record_format	dspace
spelling	oai:doaj.org-article:41e649e2638a42c8b3b5d343a180883a2021-12-02T15:10:17ZNaringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation10.1038/s41598-020-77511-22045-2322https://doaj.org/article/41e649e2638a42c8b3b5d343a180883a2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77511-2https://doaj.org/toc/2045-2322Abstract Glucosamine-6-Phosphate synthase enzyme has been targeted for development of better and safe preservative due to its role in microbial cell wall synthesis. In recent year’s demand of preservatives for the food, cosmetics and pharmaceuticals have increased. Although, the available synthetic preservatives have associated unwanted adverse effects, soa chain of naringin derivatives were schemed synthesized and judged for antioxidant, antimicrobial, preservative efficacy, stability study and topical evaluation. Molecular docking resulted with excellent dock score and binding energy for compound 7, compound 6 and compound 1 as compared to standard drugs. Resultant data of antimicrobial activity revealed compound 7as most potent antimicrobial compound for P. mirabilis, P. aeruginosa, S. aureus, E. coli, C. albicans, and A. niger, respectively, as compared to the standard drugs. The preservative efficacy test of compound 7 in White Lotion USP showed the log cfu/mL value within prescribed limit of USP standard. Compound 7 stabilize the White lotion USP from microbial growth for a period of six months under accelerated storage condition. Compound 7 was further evaluated for toxicity by using the Draize test in rabbits and showed no sign of eye and skin irritation. The outcome demonstrated that synthesized naringin compounds showed glorious antioxidant, antimicrobial, preservative efficacy, stable and safe as compared to standards.Amit LatherSunil SharmaAnurag KhatkarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amit Lather Sunil Sharma Anurag Khatkar Naringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation
description	Abstract Glucosamine-6-Phosphate synthase enzyme has been targeted for development of better and safe preservative due to its role in microbial cell wall synthesis. In recent year’s demand of preservatives for the food, cosmetics and pharmaceuticals have increased. Although, the available synthetic preservatives have associated unwanted adverse effects, soa chain of naringin derivatives were schemed synthesized and judged for antioxidant, antimicrobial, preservative efficacy, stability study and topical evaluation. Molecular docking resulted with excellent dock score and binding energy for compound 7, compound 6 and compound 1 as compared to standard drugs. Resultant data of antimicrobial activity revealed compound 7as most potent antimicrobial compound for P. mirabilis, P. aeruginosa, S. aureus, E. coli, C. albicans, and A. niger, respectively, as compared to the standard drugs. The preservative efficacy test of compound 7 in White Lotion USP showed the log cfu/mL value within prescribed limit of USP standard. Compound 7 stabilize the White lotion USP from microbial growth for a period of six months under accelerated storage condition. Compound 7 was further evaluated for toxicity by using the Draize test in rabbits and showed no sign of eye and skin irritation. The outcome demonstrated that synthesized naringin compounds showed glorious antioxidant, antimicrobial, preservative efficacy, stable and safe as compared to standards.
format	article
author	Amit Lather Sunil Sharma Anurag Khatkar
author_facet	Amit Lather Sunil Sharma Anurag Khatkar
author_sort	Amit Lather
title	Naringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation
title_short	Naringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation
title_full	Naringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation
title_fullStr	Naringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation
title_full_unstemmed	Naringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation
title_sort	naringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/41e649e2638a42c8b3b5d343a180883a
work_keys_str_mv	AT amitlather naringinderivativesasglucosamine6phosphatesynthaseinhibitorsbasedpreservativesandtheirbiologicalevaluation AT sunilsharma naringinderivativesasglucosamine6phosphatesynthaseinhibitorsbasedpreservativesandtheirbiologicalevaluation AT anuragkhatkar naringinderivativesasglucosamine6phosphatesynthaseinhibitorsbasedpreservativesandtheirbiologicalevaluation
_version_	1718387684705042432

Naringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation

Ejemplares similares