Maternally-transmitted microbiota affects odor emission and preference in Drosophila larva

Abstract Experimental studies show that early sensory experience often affects subsequent sensory preference, suggesting that the heterogeneity of sensory cues in nature could induce significant inter-individual behavioral variation, potentially contributing to maintain intraspecific diversity. To t...

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Autores principales:	Jean-Pierre Farine, Wafa Habbachi, Jérôme Cortot, Suzy Roche, Jean-François Ferveur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41e6fa426fd0434cbd8746e3b39d6397
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spelling	oai:doaj.org-article:41e6fa426fd0434cbd8746e3b39d63972021-12-02T11:41:00ZMaternally-transmitted microbiota affects odor emission and preference in Drosophila larva10.1038/s41598-017-04922-z2045-2322https://doaj.org/article/41e6fa426fd0434cbd8746e3b39d63972017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04922-zhttps://doaj.org/toc/2045-2322Abstract Experimental studies show that early sensory experience often affects subsequent sensory preference, suggesting that the heterogeneity of sensory cues in nature could induce significant inter-individual behavioral variation, potentially contributing to maintain intraspecific diversity. To test this hypothesis, we explored the behavioral effect induced by variation in the levels of a self-produced chemical, acetoin, and its link with intraspecific diversity. Acetoin is a pheromone-like substance produced by gut-associated microorganisms in Drosophila. Using wild-type Drosophila melanogaster populations producing variable acetoin levels, we (i) characterized factors involved in this variation and (ii) manipulated some of these factors to affect acetoin responses in larvae. We found that increased and decreased variations in acetoin levels were caused by microorganisms associated with the outside and inside of the egg, respectively. Wild-type larvae preferred acetoin-rich food only when they both produced and were exposed to substantial amounts of acetoin. The removal of the outside of the egg or the genetic alteration of olfaction abolished this preference. In contrast, larvae exposed to high doses of synthetic acetoin were repulsed by acetoin. The similar effects obtained with freshly caught wild-type lines suggest that this acetoin “production-preference” link underlies the diversity of acetoin-producing microorganisms among natural D. melanogaster populations.Jean-Pierre FarineWafa HabbachiJérôme CortotSuzy RocheJean-François FerveurNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jean-Pierre Farine Wafa Habbachi Jérôme Cortot Suzy Roche Jean-François Ferveur Maternally-transmitted microbiota affects odor emission and preference in Drosophila larva
description	Abstract Experimental studies show that early sensory experience often affects subsequent sensory preference, suggesting that the heterogeneity of sensory cues in nature could induce significant inter-individual behavioral variation, potentially contributing to maintain intraspecific diversity. To test this hypothesis, we explored the behavioral effect induced by variation in the levels of a self-produced chemical, acetoin, and its link with intraspecific diversity. Acetoin is a pheromone-like substance produced by gut-associated microorganisms in Drosophila. Using wild-type Drosophila melanogaster populations producing variable acetoin levels, we (i) characterized factors involved in this variation and (ii) manipulated some of these factors to affect acetoin responses in larvae. We found that increased and decreased variations in acetoin levels were caused by microorganisms associated with the outside and inside of the egg, respectively. Wild-type larvae preferred acetoin-rich food only when they both produced and were exposed to substantial amounts of acetoin. The removal of the outside of the egg or the genetic alteration of olfaction abolished this preference. In contrast, larvae exposed to high doses of synthetic acetoin were repulsed by acetoin. The similar effects obtained with freshly caught wild-type lines suggest that this acetoin “production-preference” link underlies the diversity of acetoin-producing microorganisms among natural D. melanogaster populations.
format	article
author	Jean-Pierre Farine Wafa Habbachi Jérôme Cortot Suzy Roche Jean-François Ferveur
author_facet	Jean-Pierre Farine Wafa Habbachi Jérôme Cortot Suzy Roche Jean-François Ferveur
author_sort	Jean-Pierre Farine
title	Maternally-transmitted microbiota affects odor emission and preference in Drosophila larva
title_short	Maternally-transmitted microbiota affects odor emission and preference in Drosophila larva
title_full	Maternally-transmitted microbiota affects odor emission and preference in Drosophila larva
title_fullStr	Maternally-transmitted microbiota affects odor emission and preference in Drosophila larva
title_full_unstemmed	Maternally-transmitted microbiota affects odor emission and preference in Drosophila larva
title_sort	maternally-transmitted microbiota affects odor emission and preference in drosophila larva
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/41e6fa426fd0434cbd8746e3b39d6397
work_keys_str_mv	AT jeanpierrefarine maternallytransmittedmicrobiotaaffectsodoremissionandpreferenceindrosophilalarva AT wafahabbachi maternallytransmittedmicrobiotaaffectsodoremissionandpreferenceindrosophilalarva AT jeromecortot maternallytransmittedmicrobiotaaffectsodoremissionandpreferenceindrosophilalarva AT suzyroche maternallytransmittedmicrobiotaaffectsodoremissionandpreferenceindrosophilalarva AT jeanfrancoisferveur maternallytransmittedmicrobiotaaffectsodoremissionandpreferenceindrosophilalarva
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Maternally-transmitted microbiota affects odor emission and preference in Drosophila larva

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