The nuclear protein Sge1 of Fusarium oxysporum is required for parasitic growth.

Dimorphism or morphogenic conversion is exploited by several pathogenic fungi and is required for tissue invasion and/or survival in the host. We have identified a homolog of a master regulator of this morphological switch in the plant pathogenic fungus Fusarium oxysporum f. sp. lycopersici. This no...

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Autores principales:	Caroline B Michielse, Ringo van Wijk, Linda Reijnen, Erik M M Manders, Sonja Boas, Chantal Olivain, Claude Alabouvette, Martijn Rep
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/41e71779d2074367881057bfd62b2185
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spelling	oai:doaj.org-article:41e71779d2074367881057bfd62b21852021-11-25T05:48:34ZThe nuclear protein Sge1 of Fusarium oxysporum is required for parasitic growth.1553-73661553-737410.1371/journal.ppat.1000637https://doaj.org/article/41e71779d2074367881057bfd62b21852009-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19851506/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Dimorphism or morphogenic conversion is exploited by several pathogenic fungi and is required for tissue invasion and/or survival in the host. We have identified a homolog of a master regulator of this morphological switch in the plant pathogenic fungus Fusarium oxysporum f. sp. lycopersici. This non-dimorphic fungus causes vascular wilt disease in tomato by penetrating the plant roots and colonizing the vascular tissue. Gene knock-out and complementation studies established that the gene for this putative regulator, SGE1 (SIX Gene Expression 1), is essential for pathogenicity. In addition, microscopic analysis using fluorescent proteins revealed that Sge1 is localized in the nucleus, is not required for root colonization and penetration, but is required for parasitic growth. Furthermore, Sge1 is required for expression of genes encoding effectors that are secreted during infection. We propose that Sge1 is required in F. oxysporum and other non-dimorphic (plant) pathogenic fungi for parasitic growth.Caroline B MichielseRingo van WijkLinda ReijnenErik M M MandersSonja BoasChantal OlivainClaude AlabouvetteMartijn RepPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 5, Iss 10, p e1000637 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Caroline B Michielse Ringo van Wijk Linda Reijnen Erik M M Manders Sonja Boas Chantal Olivain Claude Alabouvette Martijn Rep The nuclear protein Sge1 of Fusarium oxysporum is required for parasitic growth.
description	Dimorphism or morphogenic conversion is exploited by several pathogenic fungi and is required for tissue invasion and/or survival in the host. We have identified a homolog of a master regulator of this morphological switch in the plant pathogenic fungus Fusarium oxysporum f. sp. lycopersici. This non-dimorphic fungus causes vascular wilt disease in tomato by penetrating the plant roots and colonizing the vascular tissue. Gene knock-out and complementation studies established that the gene for this putative regulator, SGE1 (SIX Gene Expression 1), is essential for pathogenicity. In addition, microscopic analysis using fluorescent proteins revealed that Sge1 is localized in the nucleus, is not required for root colonization and penetration, but is required for parasitic growth. Furthermore, Sge1 is required for expression of genes encoding effectors that are secreted during infection. We propose that Sge1 is required in F. oxysporum and other non-dimorphic (plant) pathogenic fungi for parasitic growth.
format	article
author	Caroline B Michielse Ringo van Wijk Linda Reijnen Erik M M Manders Sonja Boas Chantal Olivain Claude Alabouvette Martijn Rep
author_facet	Caroline B Michielse Ringo van Wijk Linda Reijnen Erik M M Manders Sonja Boas Chantal Olivain Claude Alabouvette Martijn Rep
author_sort	Caroline B Michielse
title	The nuclear protein Sge1 of Fusarium oxysporum is required for parasitic growth.
title_short	The nuclear protein Sge1 of Fusarium oxysporum is required for parasitic growth.
title_full	The nuclear protein Sge1 of Fusarium oxysporum is required for parasitic growth.
title_fullStr	The nuclear protein Sge1 of Fusarium oxysporum is required for parasitic growth.
title_full_unstemmed	The nuclear protein Sge1 of Fusarium oxysporum is required for parasitic growth.
title_sort	nuclear protein sge1 of fusarium oxysporum is required for parasitic growth.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/41e71779d2074367881057bfd62b2185
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The nuclear protein Sge1 of Fusarium oxysporum is required for parasitic growth.

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