Bayesian analysis of depth resolved OCT attenuation coefficients

Abstract Optical coherence tomography (OCT) is an optical technique which allows for volumetric visualization of the internal structures of translucent materials. Additional information can be gained by measuring the rate of signal attenuation in depth. Techniques have been developed to estimate the...

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Autores principales:	Lionel D. Fiske, Maurice C. G. Aalders, Mitra Almasian, Ton G. van Leeuwen, Aggelos K. Katsaggelos, Oliver Cossairt, Dirk J. Faber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41e7ff7f194c47d9ad4e5839af87e099
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spelling	oai:doaj.org-article:41e7ff7f194c47d9ad4e5839af87e0992021-12-02T14:16:34ZBayesian analysis of depth resolved OCT attenuation coefficients10.1038/s41598-021-81713-72045-2322https://doaj.org/article/41e7ff7f194c47d9ad4e5839af87e0992021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81713-7https://doaj.org/toc/2045-2322Abstract Optical coherence tomography (OCT) is an optical technique which allows for volumetric visualization of the internal structures of translucent materials. Additional information can be gained by measuring the rate of signal attenuation in depth. Techniques have been developed to estimate the rate of attenuation on a voxel by voxel basis. This depth resolved attenuation analysis gives insight into tissue structure and organization in a spatially resolved way. However, the presence of speckle in the OCT measurement causes the attenuation coefficient image to contain unrealistic fluctuations and makes the reliability of these images at the voxel level poor. While the distribution of speckle in OCT images has appeared in literature, the resulting voxelwise corruption of the attenuation analysis has not. In this work, the estimated depth resolved attenuation coefficient from OCT data with speckle is shown to be approximately exponentially distributed. After this, a prior distribution for the depth resolved attenuation coefficient is derived for a simple system using statistical mechanics. Finally, given a set of depth resolved estimates which were made from OCT data in the presence of speckle, a posterior probability distribution for the true voxelwise attenuation coefficient is derived and a Bayesian voxelwise estimator for the coefficient is given. These results are demonstrated in simulation and validated experimentally.Lionel D. FiskeMaurice C. G. AaldersMitra AlmasianTon G. van LeeuwenAggelos K. KatsaggelosOliver CossairtDirk J. FaberNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lionel D. Fiske Maurice C. G. Aalders Mitra Almasian Ton G. van Leeuwen Aggelos K. Katsaggelos Oliver Cossairt Dirk J. Faber Bayesian analysis of depth resolved OCT attenuation coefficients
description	Abstract Optical coherence tomography (OCT) is an optical technique which allows for volumetric visualization of the internal structures of translucent materials. Additional information can be gained by measuring the rate of signal attenuation in depth. Techniques have been developed to estimate the rate of attenuation on a voxel by voxel basis. This depth resolved attenuation analysis gives insight into tissue structure and organization in a spatially resolved way. However, the presence of speckle in the OCT measurement causes the attenuation coefficient image to contain unrealistic fluctuations and makes the reliability of these images at the voxel level poor. While the distribution of speckle in OCT images has appeared in literature, the resulting voxelwise corruption of the attenuation analysis has not. In this work, the estimated depth resolved attenuation coefficient from OCT data with speckle is shown to be approximately exponentially distributed. After this, a prior distribution for the depth resolved attenuation coefficient is derived for a simple system using statistical mechanics. Finally, given a set of depth resolved estimates which were made from OCT data in the presence of speckle, a posterior probability distribution for the true voxelwise attenuation coefficient is derived and a Bayesian voxelwise estimator for the coefficient is given. These results are demonstrated in simulation and validated experimentally.
format	article
author	Lionel D. Fiske Maurice C. G. Aalders Mitra Almasian Ton G. van Leeuwen Aggelos K. Katsaggelos Oliver Cossairt Dirk J. Faber
author_facet	Lionel D. Fiske Maurice C. G. Aalders Mitra Almasian Ton G. van Leeuwen Aggelos K. Katsaggelos Oliver Cossairt Dirk J. Faber
author_sort	Lionel D. Fiske
title	Bayesian analysis of depth resolved OCT attenuation coefficients
title_short	Bayesian analysis of depth resolved OCT attenuation coefficients
title_full	Bayesian analysis of depth resolved OCT attenuation coefficients
title_fullStr	Bayesian analysis of depth resolved OCT attenuation coefficients
title_full_unstemmed	Bayesian analysis of depth resolved OCT attenuation coefficients
title_sort	bayesian analysis of depth resolved oct attenuation coefficients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/41e7ff7f194c47d9ad4e5839af87e099
work_keys_str_mv	AT lioneldfiske bayesiananalysisofdepthresolvedoctattenuationcoefficients AT mauricecgaalders bayesiananalysisofdepthresolvedoctattenuationcoefficients AT mitraalmasian bayesiananalysisofdepthresolvedoctattenuationcoefficients AT tongvanleeuwen bayesiananalysisofdepthresolvedoctattenuationcoefficients AT aggeloskkatsaggelos bayesiananalysisofdepthresolvedoctattenuationcoefficients AT olivercossairt bayesiananalysisofdepthresolvedoctattenuationcoefficients AT dirkjfaber bayesiananalysisofdepthresolvedoctattenuationcoefficients
_version_	1718391662868168704

Bayesian analysis of depth resolved OCT attenuation coefficients

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