Correlation between amide proton transfer-related signal intensity and diffusion and perfusion magnetic resonance imaging parameters in high-grade glioma

Abstract Amide proton transfer (APT) imaging is a magnetic resonance (MR) molecular imaging technique that is sensitive to mobile proteins and peptides in living tissue. Studies have shown that APT-related signal intensity (APTSI) parallels with the malignancy grade of gliomas, allowing the preopera...

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Autores principales:	Masanori Nakajo, Manisha Bohara, Kiyohisa Kamimura, Nayuta Higa, Takashi Yoshiura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41ea2d74b1ef4ae08b87424f724a7f29
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spelling	oai:doaj.org-article:41ea2d74b1ef4ae08b87424f724a7f292021-12-02T14:49:11ZCorrelation between amide proton transfer-related signal intensity and diffusion and perfusion magnetic resonance imaging parameters in high-grade glioma10.1038/s41598-021-90841-z2045-2322https://doaj.org/article/41ea2d74b1ef4ae08b87424f724a7f292021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90841-zhttps://doaj.org/toc/2045-2322Abstract Amide proton transfer (APT) imaging is a magnetic resonance (MR) molecular imaging technique that is sensitive to mobile proteins and peptides in living tissue. Studies have shown that APT-related signal intensity (APTSI) parallels with the malignancy grade of gliomas, allowing the preoperative assessment of tumor grades. An increased APTSI in malignant gliomas has been attributed to cytosolic proteins and peptides in proliferating tumor cells; however, the exact underlying mechanism is poorly understood. To get an insight into the mechanism of high APTSI in malignant gliomas, we investigated the correlations between APTSI and several MR imaging parameters including apparent diffusion coefficient (ADC), relative cerebral blood volume and pharmacokinetic parameters obtained in the same regions-of-interest in 22 high-grade gliomas. We found a significant positive correlation between APTSI and ADC (ρ = 0.625 and 0.490 for observers 1 and 2, respectively; p < 0.001 for both), which is known to be inversely correlated with cell density. Multiple regression analysis revealed that ADC was significantly associated with APTSI (p < 0.001 for both observers). Our results suggest possible roles of extracellular proteins and peptides in high APTSI in malignant gliomas.Masanori NakajoManisha BoharaKiyohisa KamimuraNayuta HigaTakashi YoshiuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masanori Nakajo Manisha Bohara Kiyohisa Kamimura Nayuta Higa Takashi Yoshiura Correlation between amide proton transfer-related signal intensity and diffusion and perfusion magnetic resonance imaging parameters in high-grade glioma
description	Abstract Amide proton transfer (APT) imaging is a magnetic resonance (MR) molecular imaging technique that is sensitive to mobile proteins and peptides in living tissue. Studies have shown that APT-related signal intensity (APTSI) parallels with the malignancy grade of gliomas, allowing the preoperative assessment of tumor grades. An increased APTSI in malignant gliomas has been attributed to cytosolic proteins and peptides in proliferating tumor cells; however, the exact underlying mechanism is poorly understood. To get an insight into the mechanism of high APTSI in malignant gliomas, we investigated the correlations between APTSI and several MR imaging parameters including apparent diffusion coefficient (ADC), relative cerebral blood volume and pharmacokinetic parameters obtained in the same regions-of-interest in 22 high-grade gliomas. We found a significant positive correlation between APTSI and ADC (ρ = 0.625 and 0.490 for observers 1 and 2, respectively; p < 0.001 for both), which is known to be inversely correlated with cell density. Multiple regression analysis revealed that ADC was significantly associated with APTSI (p < 0.001 for both observers). Our results suggest possible roles of extracellular proteins and peptides in high APTSI in malignant gliomas.
format	article
author	Masanori Nakajo Manisha Bohara Kiyohisa Kamimura Nayuta Higa Takashi Yoshiura
author_facet	Masanori Nakajo Manisha Bohara Kiyohisa Kamimura Nayuta Higa Takashi Yoshiura
author_sort	Masanori Nakajo
title	Correlation between amide proton transfer-related signal intensity and diffusion and perfusion magnetic resonance imaging parameters in high-grade glioma
title_short	Correlation between amide proton transfer-related signal intensity and diffusion and perfusion magnetic resonance imaging parameters in high-grade glioma
title_full	Correlation between amide proton transfer-related signal intensity and diffusion and perfusion magnetic resonance imaging parameters in high-grade glioma
title_fullStr	Correlation between amide proton transfer-related signal intensity and diffusion and perfusion magnetic resonance imaging parameters in high-grade glioma
title_full_unstemmed	Correlation between amide proton transfer-related signal intensity and diffusion and perfusion magnetic resonance imaging parameters in high-grade glioma
title_sort	correlation between amide proton transfer-related signal intensity and diffusion and perfusion magnetic resonance imaging parameters in high-grade glioma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/41ea2d74b1ef4ae08b87424f724a7f29
work_keys_str_mv	AT masanorinakajo correlationbetweenamideprotontransferrelatedsignalintensityanddiffusionandperfusionmagneticresonanceimagingparametersinhighgradeglioma AT manishabohara correlationbetweenamideprotontransferrelatedsignalintensityanddiffusionandperfusionmagneticresonanceimagingparametersinhighgradeglioma AT kiyohisakamimura correlationbetweenamideprotontransferrelatedsignalintensityanddiffusionandperfusionmagneticresonanceimagingparametersinhighgradeglioma AT nayutahiga correlationbetweenamideprotontransferrelatedsignalintensityanddiffusionandperfusionmagneticresonanceimagingparametersinhighgradeglioma AT takashiyoshiura correlationbetweenamideprotontransferrelatedsignalintensityanddiffusionandperfusionmagneticresonanceimagingparametersinhighgradeglioma
_version_	1718389505324482560

Correlation between amide proton transfer-related signal intensity and diffusion and perfusion magnetic resonance imaging parameters in high-grade glioma

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