An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells

Accurately predicting the behaviour of a genetic circuit remains difficult due to the lack of modularity. Here the authors quantify the effects of resource loading in mammalian systems and develop an endoribonuclease-based feedfoward controller to adapt gene expression to the effects of resource loa...

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Autores principales:	Ross D. Jones, Yili Qian, Velia Siciliano, Breanna DiAndreth, Jin Huh, Ron Weiss, Domitilla Del Vecchio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41ee51a0778e4e32aca6ad6f2f5dcaae
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spelling	oai:doaj.org-article:41ee51a0778e4e32aca6ad6f2f5dcaae2021-12-02T15:34:12ZAn endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells10.1038/s41467-020-19126-92041-1723https://doaj.org/article/41ee51a0778e4e32aca6ad6f2f5dcaae2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19126-9https://doaj.org/toc/2041-1723Accurately predicting the behaviour of a genetic circuit remains difficult due to the lack of modularity. Here the authors quantify the effects of resource loading in mammalian systems and develop an endoribonuclease-based feedfoward controller to adapt gene expression to the effects of resource loading.Ross D. JonesYili QianVelia SicilianoBreanna DiAndrethJin HuhRon WeissDomitilla Del VecchioNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ross D. Jones Yili Qian Velia Siciliano Breanna DiAndreth Jin Huh Ron Weiss Domitilla Del Vecchio An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
description	Accurately predicting the behaviour of a genetic circuit remains difficult due to the lack of modularity. Here the authors quantify the effects of resource loading in mammalian systems and develop an endoribonuclease-based feedfoward controller to adapt gene expression to the effects of resource loading.
format	article
author	Ross D. Jones Yili Qian Velia Siciliano Breanna DiAndreth Jin Huh Ron Weiss Domitilla Del Vecchio
author_facet	Ross D. Jones Yili Qian Velia Siciliano Breanna DiAndreth Jin Huh Ron Weiss Domitilla Del Vecchio
author_sort	Ross D. Jones
title	An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
title_short	An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
title_full	An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
title_fullStr	An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
title_full_unstemmed	An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
title_sort	endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/41ee51a0778e4e32aca6ad6f2f5dcaae
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An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells

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