An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells

An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells

Accurately predicting the behaviour of a genetic circuit remains difficult due to the lack of modularity. Here the authors quantify the effects of resource loading in mammalian systems and develop an endoribonuclease-based feedfoward controller to adapt gene expression to the effects of resource loa...

Full description

Saved in:
Bibliographic Details
Main Authors: Ross D. Jones, Yili Qian, Velia Siciliano, Breanna DiAndreth, Jin Huh, Ron Weiss, Domitilla Del Vecchio
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/41ee51a0778e4e32aca6ad6f2f5dcaae
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:doaj.org-article:41ee51a0778e4e32aca6ad6f2f5dcaae
record_format dspace
spelling oai:doaj.org-article:41ee51a0778e4e32aca6ad6f2f5dcaae2021-12-02T15:34:12ZAn endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells10.1038/s41467-020-19126-92041-1723https://doaj.org/article/41ee51a0778e4e32aca6ad6f2f5dcaae2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19126-9https://doaj.org/toc/2041-1723Accurately predicting the behaviour of a genetic circuit remains difficult due to the lack of modularity. Here the authors quantify the effects of resource loading in mammalian systems and develop an endoribonuclease-based feedfoward controller to adapt gene expression to the effects of resource loading.Ross D. JonesYili QianVelia SicilianoBreanna DiAndrethJin HuhRon WeissDomitilla Del VecchioNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ross D. Jones
Yili Qian
Velia Siciliano
Breanna DiAndreth
Jin Huh
Ron Weiss
Domitilla Del Vecchio
An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
description Accurately predicting the behaviour of a genetic circuit remains difficult due to the lack of modularity. Here the authors quantify the effects of resource loading in mammalian systems and develop an endoribonuclease-based feedfoward controller to adapt gene expression to the effects of resource loading.
format article
author Ross D. Jones
Yili Qian
Velia Siciliano
Breanna DiAndreth
Jin Huh
Ron Weiss
Domitilla Del Vecchio
author_facet Ross D. Jones
Yili Qian
Velia Siciliano
Breanna DiAndreth
Jin Huh
Ron Weiss
Domitilla Del Vecchio
author_sort Ross D. Jones
title An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
title_short An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
title_full An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
title_fullStr An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
title_full_unstemmed An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
title_sort endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/41ee51a0778e4e32aca6ad6f2f5dcaae
work_keys_str_mv AT rossdjones anendoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT yiliqian anendoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT veliasiciliano anendoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT breannadiandreth anendoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT jinhuh anendoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT ronweiss anendoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT domitilladelvecchio anendoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT rossdjones endoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT yiliqian endoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT veliasiciliano endoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT breannadiandreth endoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT jinhuh endoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT ronweiss endoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
AT domitilladelvecchio endoribonucleasebasedfeedforwardcontrollerfordecouplingresourcelimitedgeneticmodulesinmammaliancells
_version_ 1718386893622607872

Similar Items