An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells

Accurately predicting the behaviour of a genetic circuit remains difficult due to the lack of modularity. Here the authors quantify the effects of resource loading in mammalian systems and develop an endoribonuclease-based feedfoward controller to adapt gene expression to the effects of resource loa...

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Autores principales: Ross D. Jones, Yili Qian, Velia Siciliano, Breanna DiAndreth, Jin Huh, Ron Weiss, Domitilla Del Vecchio
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/41ee51a0778e4e32aca6ad6f2f5dcaae
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