Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC

Nonalcoholic fatty liver disease (NAFLD) is the leading contributor to the global burden of chronic liver diseases. The phenotypic umbrella of NAFLD spans from simple and reversible steatosis to nonalcoholic steatohepatitis (NASH), which may worsen into cirrhosis and hepatocellular carcinoma (HCC)....

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Autores principales:	Paola Dongiovanni, Marica Meroni, Miriam Longo, Silvia Fargion, Anna Ludovica Fracanzani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	NAFLD NASH heritability HCC nutrition Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/41ee9aeec43048779c58796f6c87422b
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spelling	oai:doaj.org-article:41ee9aeec43048779c58796f6c87422b2021-11-25T16:48:33ZGenetics, Immunity and Nutrition Boost the Switching from NASH to HCC10.3390/biomedicines91115242227-9059https://doaj.org/article/41ee9aeec43048779c58796f6c87422b2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1524https://doaj.org/toc/2227-9059Nonalcoholic fatty liver disease (NAFLD) is the leading contributor to the global burden of chronic liver diseases. The phenotypic umbrella of NAFLD spans from simple and reversible steatosis to nonalcoholic steatohepatitis (NASH), which may worsen into cirrhosis and hepatocellular carcinoma (HCC). Notwithstanding, HCC may develop also in the absence of advanced fibrosis, causing a delayed time in diagnosis as a consequence of the lack of HCC screening in these patients. The precise event cascade that may precipitate NASH into HCC is intricate and it entails diverse triggers, encompassing exaggerated immune response, endoplasmic reticulum (ER) and oxidative stress, organelle derangement and DNA aberrancies. All these events may be accelerated by both genetic and environmental factors. On one side, common and rare inherited variations that affect hepatic lipid remodeling, immune microenvironment and cell survival may boost the switching from steatohepatitis to liver cancer, on the other, diet-induced dysbiosis as well as nutritional and behavioral habits may furtherly precipitate tumor onset. Therefore, dietary and lifestyle interventions aimed to restore patients’ health contribute to counteract NASH progression towards HCC. Even more, the combination of therapeutic strategies with dietary advice may maximize benefits, with the pursuit to improve liver function and prolong survival.Paola DongiovanniMarica MeroniMiriam LongoSilvia FargionAnna Ludovica FracanzaniMDPI AGarticleNAFLDNASHheritabilityHCCnutritionBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1524, p 1524 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NAFLD NASH heritability HCC nutrition Biology (General) QH301-705.5
spellingShingle	NAFLD NASH heritability HCC nutrition Biology (General) QH301-705.5 Paola Dongiovanni Marica Meroni Miriam Longo Silvia Fargion Anna Ludovica Fracanzani Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC
description	Nonalcoholic fatty liver disease (NAFLD) is the leading contributor to the global burden of chronic liver diseases. The phenotypic umbrella of NAFLD spans from simple and reversible steatosis to nonalcoholic steatohepatitis (NASH), which may worsen into cirrhosis and hepatocellular carcinoma (HCC). Notwithstanding, HCC may develop also in the absence of advanced fibrosis, causing a delayed time in diagnosis as a consequence of the lack of HCC screening in these patients. The precise event cascade that may precipitate NASH into HCC is intricate and it entails diverse triggers, encompassing exaggerated immune response, endoplasmic reticulum (ER) and oxidative stress, organelle derangement and DNA aberrancies. All these events may be accelerated by both genetic and environmental factors. On one side, common and rare inherited variations that affect hepatic lipid remodeling, immune microenvironment and cell survival may boost the switching from steatohepatitis to liver cancer, on the other, diet-induced dysbiosis as well as nutritional and behavioral habits may furtherly precipitate tumor onset. Therefore, dietary and lifestyle interventions aimed to restore patients’ health contribute to counteract NASH progression towards HCC. Even more, the combination of therapeutic strategies with dietary advice may maximize benefits, with the pursuit to improve liver function and prolong survival.
format	article
author	Paola Dongiovanni Marica Meroni Miriam Longo Silvia Fargion Anna Ludovica Fracanzani
author_facet	Paola Dongiovanni Marica Meroni Miriam Longo Silvia Fargion Anna Ludovica Fracanzani
author_sort	Paola Dongiovanni
title	Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC
title_short	Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC
title_full	Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC
title_fullStr	Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC
title_full_unstemmed	Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC
title_sort	genetics, immunity and nutrition boost the switching from nash to hcc
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/41ee9aeec43048779c58796f6c87422b
work_keys_str_mv	AT paoladongiovanni geneticsimmunityandnutritionboosttheswitchingfromnashtohcc AT maricameroni geneticsimmunityandnutritionboosttheswitchingfromnashtohcc AT miriamlongo geneticsimmunityandnutritionboosttheswitchingfromnashtohcc AT silviafargion geneticsimmunityandnutritionboosttheswitchingfromnashtohcc AT annaludovicafracanzani geneticsimmunityandnutritionboosttheswitchingfromnashtohcc
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Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC

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