Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges

Anthony Bruni, Boris Gala-Lopez, Andrew R Pepper, Nasser S Abualhassan, AM James Shapiro Clinical Islet Transplant Program and Department of Surgery, University of Alberta, Edmonton, AB, Canada Abstract: Islet transplantation is a well-established therapeutic treatment for a subset of patients wit...

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Autores principales:	Bruni A, Gala-Lopez B, Pepper AR, Abualhassan NS, Shapiro AM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/41f1d86457a749239e7cad80afafdfbc
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spelling	oai:doaj.org-article:41f1d86457a749239e7cad80afafdfbc2021-12-02T00:52:11ZIslet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges1178-7007https://doaj.org/article/41f1d86457a749239e7cad80afafdfbc2014-06-01T00:00:00Zhttp://www.dovepress.com/islet-cell-transplantation-for-the-treatment-of-type-1-diabetes-recent-a17306https://doaj.org/toc/1178-7007 Anthony Bruni, Boris Gala-Lopez, Andrew R Pepper, Nasser S Abualhassan, AM James Shapiro Clinical Islet Transplant Program and Department of Surgery, University of Alberta, Edmonton, AB, Canada Abstract: Islet transplantation is a well-established therapeutic treatment for a subset of patients with complicated type I diabetes mellitus. Prior to the Edmonton Protocol, only 9% of the 267 islet transplant recipients since 1999 were insulin independent for >1 year. In 2000, the Edmonton group reported the achievement of insulin independence in seven consecutive patients, which in a collaborative team effort propagated expansion of clinical islet transplantation centers worldwide in an effort to ameliorate the consequences of this disease. To date, clinical islet transplantation has established improved success with insulin independence rates up to 5 years post-transplant with minimal complications. In spite of marked clinical success, donor availability and selection, engraftment, and side effects of immunosuppression remain as existing obstacles to be addressed to further improve this therapy. Clinical trials to improve engraftment, the availability of insulin-producing cell sources, as well as alternative transplant sites are currently under investigation to expand treatment. With ongoing experimental and clinical studies, islet transplantation continues to be an exciting and attractive therapy to treat type I diabetes mellitus with the prospect of shifting from a treatment for some to a cure for all. Keywords: islet transplantation, type I diabetes mellitus, Edmonton Protocol, engraftment, immunosuppressionBruni AGala-Lopez BPepper ARAbualhassan NSShapiro AMDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2014, Iss default, Pp 211-223 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Bruni A Gala-Lopez B Pepper AR Abualhassan NS Shapiro AM Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges
description	Anthony Bruni, Boris Gala-Lopez, Andrew R Pepper, Nasser S Abualhassan, AM James Shapiro Clinical Islet Transplant Program and Department of Surgery, University of Alberta, Edmonton, AB, Canada Abstract: Islet transplantation is a well-established therapeutic treatment for a subset of patients with complicated type I diabetes mellitus. Prior to the Edmonton Protocol, only 9% of the 267 islet transplant recipients since 1999 were insulin independent for >1 year. In 2000, the Edmonton group reported the achievement of insulin independence in seven consecutive patients, which in a collaborative team effort propagated expansion of clinical islet transplantation centers worldwide in an effort to ameliorate the consequences of this disease. To date, clinical islet transplantation has established improved success with insulin independence rates up to 5 years post-transplant with minimal complications. In spite of marked clinical success, donor availability and selection, engraftment, and side effects of immunosuppression remain as existing obstacles to be addressed to further improve this therapy. Clinical trials to improve engraftment, the availability of insulin-producing cell sources, as well as alternative transplant sites are currently under investigation to expand treatment. With ongoing experimental and clinical studies, islet transplantation continues to be an exciting and attractive therapy to treat type I diabetes mellitus with the prospect of shifting from a treatment for some to a cure for all. Keywords: islet transplantation, type I diabetes mellitus, Edmonton Protocol, engraftment, immunosuppression
format	article
author	Bruni A Gala-Lopez B Pepper AR Abualhassan NS Shapiro AM
author_facet	Bruni A Gala-Lopez B Pepper AR Abualhassan NS Shapiro AM
author_sort	Bruni A
title	Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges
title_short	Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges
title_full	Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges
title_fullStr	Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges
title_full_unstemmed	Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges
title_sort	islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/41f1d86457a749239e7cad80afafdfbc
work_keys_str_mv	AT brunia isletcelltransplantationforthetreatmentoftype1diabetesrecentadvancesandfuturechallenges AT galalopezb isletcelltransplantationforthetreatmentoftype1diabetesrecentadvancesandfuturechallenges AT pepperar isletcelltransplantationforthetreatmentoftype1diabetesrecentadvancesandfuturechallenges AT abualhassanns isletcelltransplantationforthetreatmentoftype1diabetesrecentadvancesandfuturechallenges AT shapiroam isletcelltransplantationforthetreatmentoftype1diabetesrecentadvancesandfuturechallenges
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Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges

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