Amoeboid cells use protrusions for walking, gliding and swimming.

Amoeboid cells crawl using pseudopods, which are convex extensions of the cell surface. In many laboratory experiments, cells move on a smooth substrate, but in the wild cells may experience obstacles of other cells or dead material, or may even move in liquid. To understand how cells cope with hete...

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Autor principal:	Peter J M Van Haastert
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41f2006f28c14ad5a091a82fb9460216
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spelling	oai:doaj.org-article:41f2006f28c14ad5a091a82fb94602162021-11-18T07:34:37ZAmoeboid cells use protrusions for walking, gliding and swimming.1932-620310.1371/journal.pone.0027532https://doaj.org/article/41f2006f28c14ad5a091a82fb94602162011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22096590/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Amoeboid cells crawl using pseudopods, which are convex extensions of the cell surface. In many laboratory experiments, cells move on a smooth substrate, but in the wild cells may experience obstacles of other cells or dead material, or may even move in liquid. To understand how cells cope with heterogeneous environments we have investigated the pseudopod life cycle of wild type and mutant cells moving on a substrate and when suspended in liquid. We show that the same pseudopod cycle can provide three types of movement that we address as walking, gliding and swimming. In walking, the extending pseudopod will adhere firmly to the substrate, which allows cells to generate forces to bypass obstacles. Mutant cells with compromised adhesion can move much faster than wild type cells on a smooth substrate (gliding), but cannot move effectively against obstacles that provide resistance. In a liquid, when swimming, the extending pseudopods convert to side-bumps that move rapidly to the rear of the cells. Calculations suggest that these bumps provide sufficient drag force to mediate the observed forward swimming of the cell.Peter J M Van HaastertPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27532 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter J M Van Haastert Amoeboid cells use protrusions for walking, gliding and swimming.
description	Amoeboid cells crawl using pseudopods, which are convex extensions of the cell surface. In many laboratory experiments, cells move on a smooth substrate, but in the wild cells may experience obstacles of other cells or dead material, or may even move in liquid. To understand how cells cope with heterogeneous environments we have investigated the pseudopod life cycle of wild type and mutant cells moving on a substrate and when suspended in liquid. We show that the same pseudopod cycle can provide three types of movement that we address as walking, gliding and swimming. In walking, the extending pseudopod will adhere firmly to the substrate, which allows cells to generate forces to bypass obstacles. Mutant cells with compromised adhesion can move much faster than wild type cells on a smooth substrate (gliding), but cannot move effectively against obstacles that provide resistance. In a liquid, when swimming, the extending pseudopods convert to side-bumps that move rapidly to the rear of the cells. Calculations suggest that these bumps provide sufficient drag force to mediate the observed forward swimming of the cell.
format	article
author	Peter J M Van Haastert
author_facet	Peter J M Van Haastert
author_sort	Peter J M Van Haastert
title	Amoeboid cells use protrusions for walking, gliding and swimming.
title_short	Amoeboid cells use protrusions for walking, gliding and swimming.
title_full	Amoeboid cells use protrusions for walking, gliding and swimming.
title_fullStr	Amoeboid cells use protrusions for walking, gliding and swimming.
title_full_unstemmed	Amoeboid cells use protrusions for walking, gliding and swimming.
title_sort	amoeboid cells use protrusions for walking, gliding and swimming.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/41f2006f28c14ad5a091a82fb9460216
work_keys_str_mv	AT peterjmvanhaastert amoeboidcellsuseprotrusionsforwalkingglidingandswimming
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Amoeboid cells use protrusions for walking, gliding and swimming.

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