Is There More Than One Road to Nevus-Associated Melanoma?

The association of melanoma with a preexisting nevus is still a debated subject. Histopathological data support an associated nevus in approximately 30% of all excised melanomas. The annual risk of an individual melanocytic nevus becoming malignant is extremely low and has been estimated to be appr...

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Autores principales: Roberta Vezzoni, Claudio Conforti, Silvia Vichi, Roberta Giuffrida, Chiara Retrosi, Giovanni Magaton-Rizzi, Nicola di Meo, Maria Antonietta Pizzichetta, Iris Zalaudek
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Publicado: Mattioli1885 2020
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Acceso en línea:https://doaj.org/article/41f501fd0f8b4316adf6cccef8c20b7c
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spelling oai:doaj.org-article:41f501fd0f8b4316adf6cccef8c20b7c2021-11-17T08:28:53ZIs There More Than One Road to Nevus-Associated Melanoma?10.5826/dpc.1002a282160-9381https://doaj.org/article/41f501fd0f8b4316adf6cccef8c20b7c2020-04-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1039https://doaj.org/toc/2160-9381 The association of melanoma with a preexisting nevus is still a debated subject. Histopathological data support an associated nevus in approximately 30% of all excised melanomas. The annual risk of an individual melanocytic nevus becoming malignant is extremely low and has been estimated to be approximately 0.0005% (or less than 1 in 200,000) before the age of 40 years, to 0.003% (1 in 33,000) in patients older than 60 years. Current understanding, based on the noticeable, small, truly congenital nevi and nevi acquired early in life, is that the first develops before puberty, presents with a dermoscopic globular pattern, and persists for the lifetime, becoming later a dermal nevus in the adult. In contrast, acquired melanocytic nevi develop mostly at puberty and usually undergo spontaneous involution after the fifth decade of life. The purpose of this review is to analyze the data of the literature and to propose, on the basis of epidemiological and clinical-dermoscopic characteristics, a new model of melanogenesis of nevus-associated melanoma. Roberta VezzoniClaudio ConfortiSilvia VichiRoberta GiuffridaChiara RetrosiGiovanni Magaton-RizziNicola di MeoMaria Antonietta PizzichettaIris ZalaudekMattioli1885articlenevus-associated melanomamelanomamelanogenesisdermoscopyDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 10, Iss 2 (2020)
institution DOAJ
collection DOAJ
language EN
topic nevus-associated melanoma
melanoma
melanogenesis
dermoscopy
Dermatology
RL1-803
spellingShingle nevus-associated melanoma
melanoma
melanogenesis
dermoscopy
Dermatology
RL1-803
Roberta Vezzoni
Claudio Conforti
Silvia Vichi
Roberta Giuffrida
Chiara Retrosi
Giovanni Magaton-Rizzi
Nicola di Meo
Maria Antonietta Pizzichetta
Iris Zalaudek
Is There More Than One Road to Nevus-Associated Melanoma?
description The association of melanoma with a preexisting nevus is still a debated subject. Histopathological data support an associated nevus in approximately 30% of all excised melanomas. The annual risk of an individual melanocytic nevus becoming malignant is extremely low and has been estimated to be approximately 0.0005% (or less than 1 in 200,000) before the age of 40 years, to 0.003% (1 in 33,000) in patients older than 60 years. Current understanding, based on the noticeable, small, truly congenital nevi and nevi acquired early in life, is that the first develops before puberty, presents with a dermoscopic globular pattern, and persists for the lifetime, becoming later a dermal nevus in the adult. In contrast, acquired melanocytic nevi develop mostly at puberty and usually undergo spontaneous involution after the fifth decade of life. The purpose of this review is to analyze the data of the literature and to propose, on the basis of epidemiological and clinical-dermoscopic characteristics, a new model of melanogenesis of nevus-associated melanoma.
format article
author Roberta Vezzoni
Claudio Conforti
Silvia Vichi
Roberta Giuffrida
Chiara Retrosi
Giovanni Magaton-Rizzi
Nicola di Meo
Maria Antonietta Pizzichetta
Iris Zalaudek
author_facet Roberta Vezzoni
Claudio Conforti
Silvia Vichi
Roberta Giuffrida
Chiara Retrosi
Giovanni Magaton-Rizzi
Nicola di Meo
Maria Antonietta Pizzichetta
Iris Zalaudek
author_sort Roberta Vezzoni
title Is There More Than One Road to Nevus-Associated Melanoma?
title_short Is There More Than One Road to Nevus-Associated Melanoma?
title_full Is There More Than One Road to Nevus-Associated Melanoma?
title_fullStr Is There More Than One Road to Nevus-Associated Melanoma?
title_full_unstemmed Is There More Than One Road to Nevus-Associated Melanoma?
title_sort is there more than one road to nevus-associated melanoma?
publisher Mattioli1885
publishDate 2020
url https://doaj.org/article/41f501fd0f8b4316adf6cccef8c20b7c
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