Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults

Abstract High neuroticism is related to cardiovascular morbidity. Early detection of metabolic and cardiovascular risk is important in high-risk groups to enable preventive measures. The aim of this study was therefore to explore if neuroticism is associated with early biomarkers for cardiovascular...

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Autores principales: Mikaela Syk, Johan Isaksson, Annica J. Rasmusson, Lisa Ekselius, Janet L. Cunningham
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:41f917db901c48acbe177e42c1aeda092021-12-02T15:37:58ZNeuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults10.1038/s41598-021-89251-y2045-2322https://doaj.org/article/41f917db901c48acbe177e42c1aeda092021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89251-yhttps://doaj.org/toc/2045-2322Abstract High neuroticism is related to cardiovascular morbidity. Early detection of metabolic and cardiovascular risk is important in high-risk groups to enable preventive measures. The aim of this study was therefore to explore if neuroticism is associated with early biomarkers for cardiovascular and metabolic disease in young adults from a psychiatry cohort. Blood samples and self-ratings on neuroticism with the Swedish universities Scales of Personality (SSP) questionnaire were collected from 172 psychiatric outpatients and 46 healthy controls. The blood samples were analysed for plasma leptin, adiponectin, CRP, IL-6 and TNF-α. Associations between neuroticism and biomarkers were assessed using Spearman’s correlation coefficients and generalized linear models adjusting for confounders. In the adjusted generalized linear models, neuroticism predicted the leptin/adiponectin ratio (p = 0.003), leptin (p = 0.004) and IL-6 (p = 0.001). These associations were not better explained by current major depressive disorder and/or anxiety disorder. Adiponectin, CRP and TNF-α were not associated with neuroticism. In conclusion, the findings suggest that high neuroticism is related to elevated levels of plasma leptin/adiponectin ratio, leptin and IL-6 in young adults. Young adults with high neuroticism may therefore benefit from preventive interventions to decrease the risk for future metabolic and cardiovascular morbidity, but more research is required to test this hypothesis.Mikaela SykJohan IsakssonAnnica J. RasmussonLisa EkseliusJanet L. CunninghamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Mikaela Syk
Johan Isaksson
Annica J. Rasmusson
Lisa Ekselius
Janet L. Cunningham
Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
description Abstract High neuroticism is related to cardiovascular morbidity. Early detection of metabolic and cardiovascular risk is important in high-risk groups to enable preventive measures. The aim of this study was therefore to explore if neuroticism is associated with early biomarkers for cardiovascular and metabolic disease in young adults from a psychiatry cohort. Blood samples and self-ratings on neuroticism with the Swedish universities Scales of Personality (SSP) questionnaire were collected from 172 psychiatric outpatients and 46 healthy controls. The blood samples were analysed for plasma leptin, adiponectin, CRP, IL-6 and TNF-α. Associations between neuroticism and biomarkers were assessed using Spearman’s correlation coefficients and generalized linear models adjusting for confounders. In the adjusted generalized linear models, neuroticism predicted the leptin/adiponectin ratio (p = 0.003), leptin (p = 0.004) and IL-6 (p = 0.001). These associations were not better explained by current major depressive disorder and/or anxiety disorder. Adiponectin, CRP and TNF-α were not associated with neuroticism. In conclusion, the findings suggest that high neuroticism is related to elevated levels of plasma leptin/adiponectin ratio, leptin and IL-6 in young adults. Young adults with high neuroticism may therefore benefit from preventive interventions to decrease the risk for future metabolic and cardiovascular morbidity, but more research is required to test this hypothesis.
format article
author Mikaela Syk
Johan Isaksson
Annica J. Rasmusson
Lisa Ekselius
Janet L. Cunningham
author_facet Mikaela Syk
Johan Isaksson
Annica J. Rasmusson
Lisa Ekselius
Janet L. Cunningham
author_sort Mikaela Syk
title Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
title_short Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
title_full Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
title_fullStr Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
title_full_unstemmed Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
title_sort neuroticism is positively associated with leptin/adiponectin ratio, leptin and il-6 in young adults
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/41f917db901c48acbe177e42c1aeda09
work_keys_str_mv AT mikaelasyk neuroticismispositivelyassociatedwithleptinadiponectinratioleptinandil6inyoungadults
AT johanisaksson neuroticismispositivelyassociatedwithleptinadiponectinratioleptinandil6inyoungadults
AT annicajrasmusson neuroticismispositivelyassociatedwithleptinadiponectinratioleptinandil6inyoungadults
AT lisaekselius neuroticismispositivelyassociatedwithleptinadiponectinratioleptinandil6inyoungadults
AT janetlcunningham neuroticismispositivelyassociatedwithleptinadiponectinratioleptinandil6inyoungadults
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