Gene-by-environment interactions in urban populations modulate risk phenotypes

Gene-by-environment interactions in urban populations modulate risk phenotypes

Individuals with different genotypes may respond differently to environmental variation. Here, Favé et al. find substantial impacts of different environment exposures on the transcriptome and clinical endophenotypes when controlling for genetic ancestry by analyzing data from ∼1000 individuals from...

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Autores principales: Marie-Julie Favé, Fabien C. Lamaze, David Soave, Alan Hodgkinson, Héloïse Gauvin, Vanessa Bruat, Jean-Christophe Grenier, Elias Gbeha, Kimberly Skead, Audrey Smargiassi, Markey Johnson, Youssef Idaghdour, Philip Awadalla
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/41fc1f6359a849bfb95ac2841971bf1d
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spelling oai:doaj.org-article:41fc1f6359a849bfb95ac2841971bf1d2021-12-02T16:56:54ZGene-by-environment interactions in urban populations modulate risk phenotypes10.1038/s41467-018-03202-22041-1723https://doaj.org/article/41fc1f6359a849bfb95ac2841971bf1d2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03202-2https://doaj.org/toc/2041-1723Individuals with different genotypes may respond differently to environmental variation. Here, Favé et al. find substantial impacts of different environment exposures on the transcriptome and clinical endophenotypes when controlling for genetic ancestry by analyzing data from ∼1000 individuals from a founder population in Quebec.Marie-Julie FavéFabien C. LamazeDavid SoaveAlan HodgkinsonHéloïse GauvinVanessa BruatJean-Christophe GrenierElias GbehaKimberly SkeadAudrey SmargiassiMarkey JohnsonYoussef IdaghdourPhilip AwadallaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marie-Julie Favé
Fabien C. Lamaze
David Soave
Alan Hodgkinson
Héloïse Gauvin
Vanessa Bruat
Jean-Christophe Grenier
Elias Gbeha
Kimberly Skead
Audrey Smargiassi
Markey Johnson
Youssef Idaghdour
Philip Awadalla
Gene-by-environment interactions in urban populations modulate risk phenotypes
description Individuals with different genotypes may respond differently to environmental variation. Here, Favé et al. find substantial impacts of different environment exposures on the transcriptome and clinical endophenotypes when controlling for genetic ancestry by analyzing data from ∼1000 individuals from a founder population in Quebec.
format article
author Marie-Julie Favé
Fabien C. Lamaze
David Soave
Alan Hodgkinson
Héloïse Gauvin
Vanessa Bruat
Jean-Christophe Grenier
Elias Gbeha
Kimberly Skead
Audrey Smargiassi
Markey Johnson
Youssef Idaghdour
Philip Awadalla
author_facet Marie-Julie Favé
Fabien C. Lamaze
David Soave
Alan Hodgkinson
Héloïse Gauvin
Vanessa Bruat
Jean-Christophe Grenier
Elias Gbeha
Kimberly Skead
Audrey Smargiassi
Markey Johnson
Youssef Idaghdour
Philip Awadalla
author_sort Marie-Julie Favé
title Gene-by-environment interactions in urban populations modulate risk phenotypes
title_short Gene-by-environment interactions in urban populations modulate risk phenotypes
title_full Gene-by-environment interactions in urban populations modulate risk phenotypes
title_fullStr Gene-by-environment interactions in urban populations modulate risk phenotypes
title_full_unstemmed Gene-by-environment interactions in urban populations modulate risk phenotypes
title_sort gene-by-environment interactions in urban populations modulate risk phenotypes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/41fc1f6359a849bfb95ac2841971bf1d
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AT fabienclamaze genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes
AT davidsoave genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes
AT alanhodgkinson genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes
AT heloisegauvin genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes
AT vanessabruat genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes
AT jeanchristophegrenier genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes
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AT kimberlyskead genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes
AT audreysmargiassi genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes
AT markeyjohnson genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes
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AT philipawadalla genebyenvironmentinteractionsinurbanpopulationsmodulateriskphenotypes
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