Advances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems

Bingbing Jiang1, John B Barnett2,3, Bingyun Li1,4,5#1Biomaterials, Bioengineering and Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, 2Department of Microbiology, Immunology, and Cell Biology, 3Center for Immunopathology and Microbial Pathogenesis, School of Medicine, 5Dep...

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Autores principales:	Bingbing Jiang, John B Barnett, Bingyun Li
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medical technology R855-855.5 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/41fd8307a348494088d591b66704d193
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spelling	oai:doaj.org-article:41fd8307a348494088d591b66704d1932021-12-02T01:11:45ZAdvances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems1177-8903https://doaj.org/article/41fd8307a348494088d591b66704d1932009-08-01T00:00:00Zhttp://www.dovepress.com/advances-in-polyelectrolyte-multilayer-nanofilms-as-tunable-drug-deliv-a3421https://doaj.org/toc/1177-8903Bingbing Jiang1, John B Barnett2,3, Bingyun Li1,4,5#1Biomaterials, Bioengineering and Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, 2Department of Microbiology, Immunology, and Cell Biology, 3Center for Immunopathology and Microbial Pathogenesis, School of Medicine, 5Department of Chemical Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, WV, USA; 4WVNano Initiative, Morgantown, WV, USA; #Aided by a grant from Osteosynthesis and Trauma Care (OTC) FoundationAbstract: There has been considerable interest in polyelectrolyte multilayer nanofilms, which have a variety of applications ranging from optical and electrochemical materials to biomedical devices. Polyelectrolyte multilayer nanofilms are constructed from aqueous solutions using electrostatic layer-by-layer self-assembly of oppositely-charged polyelectrolytes on a solid substrate. Multifunctional polyelectrolyte multilayer nanofilms have been studied using charged dyes, metal and inorganic nanoparticles, DNA, proteins, and viruses. In the past few years, there has been increasing attention to developing polyelectrolyte multilayer nanofilms as drug delivery vehicles. In this mini-review, we present recent developments in polyelectrolyte multilayer nanofilms with tunable drug delivery properties, with particular emphasis on the strategies in tuning the loading and release of drugs in polyelectrolyte multilayer nanofilms as well as their applications.Keywords: nanofilm, polyelectrolyte multilayer, drug delivery, electrostatic layer-by-layer self-assembly, biomedical device, surface modification Bingbing JiangJohn B BarnettBingyun LiDove Medical PressarticleMedical technologyR855-855.5Chemical technologyTP1-1185ENNanotechnology, Science and Applications, Vol 2009, Iss default, Pp 21-27 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5 Chemical technology TP1-1185
spellingShingle	Medical technology R855-855.5 Chemical technology TP1-1185 Bingbing Jiang John B Barnett Bingyun Li Advances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems
description	Bingbing Jiang1, John B Barnett2,3, Bingyun Li1,4,5#1Biomaterials, Bioengineering and Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, 2Department of Microbiology, Immunology, and Cell Biology, 3Center for Immunopathology and Microbial Pathogenesis, School of Medicine, 5Department of Chemical Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, WV, USA; 4WVNano Initiative, Morgantown, WV, USA; #Aided by a grant from Osteosynthesis and Trauma Care (OTC) FoundationAbstract: There has been considerable interest in polyelectrolyte multilayer nanofilms, which have a variety of applications ranging from optical and electrochemical materials to biomedical devices. Polyelectrolyte multilayer nanofilms are constructed from aqueous solutions using electrostatic layer-by-layer self-assembly of oppositely-charged polyelectrolytes on a solid substrate. Multifunctional polyelectrolyte multilayer nanofilms have been studied using charged dyes, metal and inorganic nanoparticles, DNA, proteins, and viruses. In the past few years, there has been increasing attention to developing polyelectrolyte multilayer nanofilms as drug delivery vehicles. In this mini-review, we present recent developments in polyelectrolyte multilayer nanofilms with tunable drug delivery properties, with particular emphasis on the strategies in tuning the loading and release of drugs in polyelectrolyte multilayer nanofilms as well as their applications.Keywords: nanofilm, polyelectrolyte multilayer, drug delivery, electrostatic layer-by-layer self-assembly, biomedical device, surface modification
format	article
author	Bingbing Jiang John B Barnett Bingyun Li
author_facet	Bingbing Jiang John B Barnett Bingyun Li
author_sort	Bingbing Jiang
title	Advances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems
title_short	Advances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems
title_full	Advances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems
title_fullStr	Advances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems
title_full_unstemmed	Advances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems
title_sort	advances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/41fd8307a348494088d591b66704d193
work_keys_str_mv	AT bingbingjiang advancesinpolyelectrolytemultilayernanofilmsastunabledrugdeliverysystems AT johnbbarnett advancesinpolyelectrolytemultilayernanofilmsastunabledrugdeliverysystems AT bingyunli advancesinpolyelectrolytemultilayernanofilmsastunabledrugdeliverysystems
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Advances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems

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