Bowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra

We report the use of anakinra to treat a case of a 64-year-old man diagnosed with hemophagocytic lymphohistiocytosis (HLH) with neurological involvement. After the administration of intravenous pulse corticosteroid therapy, immunoglobulin, and anakinra, the patient showed neurological recovery. Howe...

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Auteurs principaux:	Jan Adamski, Björn Jäschke, Tuomas Nieminem, Wojciech Weigl
Format:	article
Langue:	EN
Publié:	SMC MEDIA SRL 2021
Sujets:	diverticulitis haemophagocytic lymphohistiocytosis (hlh) gut interkeukin-1 (il-1) receptor antagonist gastrointestinal diseases Medicine R
Accès en ligne:	https://doaj.org/article/4200eb46fe8d41ab8eb2f56f779562c3
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id	oai:doaj.org-article:4200eb46fe8d41ab8eb2f56f779562c3
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spelling	oai:doaj.org-article:4200eb46fe8d41ab8eb2f56f779562c32021-11-09T11:21:26ZBowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra2284-259410.12890/2021_002845https://doaj.org/article/4200eb46fe8d41ab8eb2f56f779562c32021-10-01T00:00:00Zhttps://www.ejcrim.com/index.php/EJCRIM/article/view/2842https://doaj.org/toc/2284-2594We report the use of anakinra to treat a case of a 64-year-old man diagnosed with hemophagocytic lymphohistiocytosis (HLH) with neurological involvement. After the administration of intravenous pulse corticosteroid therapy, immunoglobulin, and anakinra, the patient showed neurological recovery. However, the recovery was complicated by the perforation of a pre-existing bowel diverticulum. The effect of anakinra on bowel inflammation has not yet been clearly established. It can potentially augment bowel inflammation and contribute to the risk of bowel perforation associated with the concomitant use of corticosteroids.Jan AdamskiBjörn JäschkeTuomas NieminemWojciech WeiglSMC MEDIA SRLarticlediverticulitishaemophagocytic lymphohistiocytosis (hlh)gutinterkeukin-1 (il-1) receptor antagonistgastrointestinal diseasesMedicineRENEuropean Journal of Case Reports in Internal Medicine (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diverticulitis haemophagocytic lymphohistiocytosis (hlh) gut interkeukin-1 (il-1) receptor antagonist gastrointestinal diseases Medicine R
spellingShingle	diverticulitis haemophagocytic lymphohistiocytosis (hlh) gut interkeukin-1 (il-1) receptor antagonist gastrointestinal diseases Medicine R Jan Adamski Björn Jäschke Tuomas Nieminem Wojciech Weigl Bowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra
description	We report the use of anakinra to treat a case of a 64-year-old man diagnosed with hemophagocytic lymphohistiocytosis (HLH) with neurological involvement. After the administration of intravenous pulse corticosteroid therapy, immunoglobulin, and anakinra, the patient showed neurological recovery. However, the recovery was complicated by the perforation of a pre-existing bowel diverticulum. The effect of anakinra on bowel inflammation has not yet been clearly established. It can potentially augment bowel inflammation and contribute to the risk of bowel perforation associated with the concomitant use of corticosteroids.
format	article
author	Jan Adamski Björn Jäschke Tuomas Nieminem Wojciech Weigl
author_facet	Jan Adamski Björn Jäschke Tuomas Nieminem Wojciech Weigl
author_sort	Jan Adamski
title	Bowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra
title_short	Bowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra
title_full	Bowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra
title_fullStr	Bowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra
title_full_unstemmed	Bowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra
title_sort	bowel perforation during haemophagocytic lymphohistiocytosis treatment with corticosteroids and anakinra
publisher	SMC MEDIA SRL
publishDate	2021
url	https://doaj.org/article/4200eb46fe8d41ab8eb2f56f779562c3
work_keys_str_mv	AT janadamski bowelperforationduringhaemophagocyticlymphohistiocytosistreatmentwithcorticosteroidsandanakinra AT bjornjaschke bowelperforationduringhaemophagocyticlymphohistiocytosistreatmentwithcorticosteroidsandanakinra AT tuomasnieminem bowelperforationduringhaemophagocyticlymphohistiocytosistreatmentwithcorticosteroidsandanakinra AT wojciechweigl bowelperforationduringhaemophagocyticlymphohistiocytosistreatmentwithcorticosteroidsandanakinra
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Bowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra

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