Renal function after partial nephrectomy following intra-arterial embolization of renal tumors

Abstract Laparoscopic Partial Nephrectomy (LPN) after intra-arterial Embolization of renal tumors (LPNE) in a hybrid operating room allows renal tumor enucleation without dissection and clamping of the renal pedicle. The purpose was to assess the potential negative impact of embolization on the rena...

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Autores principales:	Germain Bréhier, Antoine Bouvier, Louis Besnier, Serge Willoteaux, Cosmina Nedelcu, Thibaut Culty, Christophe Aubé, Pierre Bigot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4202b54b0813442081bf1c2e4e429408
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spelling	oai:doaj.org-article:4202b54b0813442081bf1c2e4e4294082021-12-02T15:09:31ZRenal function after partial nephrectomy following intra-arterial embolization of renal tumors10.1038/s41598-020-78461-52045-2322https://doaj.org/article/4202b54b0813442081bf1c2e4e4294082020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78461-5https://doaj.org/toc/2045-2322Abstract Laparoscopic Partial Nephrectomy (LPN) after intra-arterial Embolization of renal tumors (LPNE) in a hybrid operating room allows renal tumor enucleation without dissection and clamping of the renal pedicle. The purpose was to assess the potential negative impact of embolization on the renal function. This prospective monocentric study included all patients treated with LPNE between May 2015 and June 2019. Clinical data was collected and incorporated into the UroCCR database (NCT03293563). Glomerular Filtration Rate (GFR) and Computed Tomography Renal Volume (CTRV) were compared before and after 6 months following LPNE. The mean post-operative GFR was 86.6 mL/min (SD 22.9). The mean GFR loss was 9.4% (SD 15.1) and the median renal parenchyma loss was 21 mL (SD 20.6). Using a threshold of 25% GFR loss, age was the only significant predictive factor of renal function impairment according to bivariate (59.5 vs 69.3 years, p = 0.017) and multivariable analysis (OR 1.075, CI 1–1.2], p = 0.05). Significant renal function impairment was not correlated with the renal parenchymal volume loss (OR 0.987, CI [0.95–1.02], p = 0.435). Renal function impairment after LPNE seems to be comparable to other techniques of partial nephrectomy.Germain BréhierAntoine BouvierLouis BesnierSerge WilloteauxCosmina NedelcuThibaut CultyChristophe AubéPierre BigotNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Germain Bréhier Antoine Bouvier Louis Besnier Serge Willoteaux Cosmina Nedelcu Thibaut Culty Christophe Aubé Pierre Bigot Renal function after partial nephrectomy following intra-arterial embolization of renal tumors
description	Abstract Laparoscopic Partial Nephrectomy (LPN) after intra-arterial Embolization of renal tumors (LPNE) in a hybrid operating room allows renal tumor enucleation without dissection and clamping of the renal pedicle. The purpose was to assess the potential negative impact of embolization on the renal function. This prospective monocentric study included all patients treated with LPNE between May 2015 and June 2019. Clinical data was collected and incorporated into the UroCCR database (NCT03293563). Glomerular Filtration Rate (GFR) and Computed Tomography Renal Volume (CTRV) were compared before and after 6 months following LPNE. The mean post-operative GFR was 86.6 mL/min (SD 22.9). The mean GFR loss was 9.4% (SD 15.1) and the median renal parenchyma loss was 21 mL (SD 20.6). Using a threshold of 25% GFR loss, age was the only significant predictive factor of renal function impairment according to bivariate (59.5 vs 69.3 years, p = 0.017) and multivariable analysis (OR 1.075, CI 1–1.2], p = 0.05). Significant renal function impairment was not correlated with the renal parenchymal volume loss (OR 0.987, CI [0.95–1.02], p = 0.435). Renal function impairment after LPNE seems to be comparable to other techniques of partial nephrectomy.
format	article
author	Germain Bréhier Antoine Bouvier Louis Besnier Serge Willoteaux Cosmina Nedelcu Thibaut Culty Christophe Aubé Pierre Bigot
author_facet	Germain Bréhier Antoine Bouvier Louis Besnier Serge Willoteaux Cosmina Nedelcu Thibaut Culty Christophe Aubé Pierre Bigot
author_sort	Germain Bréhier
title	Renal function after partial nephrectomy following intra-arterial embolization of renal tumors
title_short	Renal function after partial nephrectomy following intra-arterial embolization of renal tumors
title_full	Renal function after partial nephrectomy following intra-arterial embolization of renal tumors
title_fullStr	Renal function after partial nephrectomy following intra-arterial embolization of renal tumors
title_full_unstemmed	Renal function after partial nephrectomy following intra-arterial embolization of renal tumors
title_sort	renal function after partial nephrectomy following intra-arterial embolization of renal tumors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4202b54b0813442081bf1c2e4e429408
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Renal function after partial nephrectomy following intra-arterial embolization of renal tumors

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