Anti-Biofouling Coatings on the Tooth Surface and Hydroxyapatite

Li Zhou,1 Hai Ming Wong,1 Quan Li Li2 1Department of Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong, SAR 999077, People’s Republic of China; 2Key Laboratory of Oral Diseases Research of Anhui Province, College and Hospital of Stomatology, Anhui Medical U...

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Autores principales:	Zhou L, Wong HM, Li QL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	anti-biofouling coating antibacterial agent hydroxyapatite tooth surface binding Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4206c8a4c67945518eb3afeca2881d7f
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spelling	oai:doaj.org-article:4206c8a4c67945518eb3afeca2881d7f2021-12-02T15:05:51ZAnti-Biofouling Coatings on the Tooth Surface and Hydroxyapatite1178-2013https://doaj.org/article/4206c8a4c67945518eb3afeca2881d7f2020-11-01T00:00:00Zhttps://www.dovepress.com/anti-biofouling-coatings-on-the-tooth-surface-and-hydroxyapatite-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Li Zhou,1 Hai Ming Wong,1 Quan Li Li2 1Department of Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong, SAR 999077, People’s Republic of China; 2Key Laboratory of Oral Diseases Research of Anhui Province, College and Hospital of Stomatology, Anhui Medical University, Hefei 230000, People’s Republic of ChinaCorrespondence: Hai Ming WongFaculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Hong Kong, SAR 999077, People’s Republic of ChinaTel +852 28590261Fax +852 25593803Email wonghmg@hku.hkQuan Li LiCollege and Hospital of Stomatology, Anhui Medical University, No. 69, Meishan Road, Hefei 230000, People’s Republic of ChinaEmail ql-li@126.comAbstract: Dental plaque is one type of biofouling on the tooth surface that consists of a diverse population of microorganisms and extracellular matrix and causes oral diseases and even systematic diseases. Numerous studies have focused on preventing bacteria and proteins on tooth surfaces, especially with anti-biofouling coatings. Anti-biofouling coatings can be stable and sustainable over the long term on the tooth surface in the complex oral environment. In this review, numerous anti-biofouling coatings on the tooth surface and hydroxyapatite (as the main component of dental hard tissue) were summarized based on their mechanisms, which include three major strategies: antiprotein and antibacterial adhesion through chemical modification, contact killing through the modification of antimicrobial agents, and antibacterial agent release. The first strategy of coatings can resist the adsorption of proteins and bacteria. However, these coatings use passive strategies and cannot kill bacteria. The second strategy can interact with the cell membrane of bacteria to cause bacterial death. Due to the possibility of delivering a high antibacterial agent concentration locally, the third strategy is recommended and will be the trend of local drug use in dentistry in the future.Keywords: anti-biofouling coating, antibacterial agent, hydroxyapatite, tooth surface, bindingZhou LWong HMLi QLDove Medical Pressarticleanti-biofouling coatingantibacterial agenthydroxyapatitetooth surfacebindingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8963-8982 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-biofouling coating antibacterial agent hydroxyapatite tooth surface binding Medicine (General) R5-920
spellingShingle	anti-biofouling coating antibacterial agent hydroxyapatite tooth surface binding Medicine (General) R5-920 Zhou L Wong HM Li QL Anti-Biofouling Coatings on the Tooth Surface and Hydroxyapatite
description	Li Zhou,1 Hai Ming Wong,1 Quan Li Li2 1Department of Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong, SAR 999077, People’s Republic of China; 2Key Laboratory of Oral Diseases Research of Anhui Province, College and Hospital of Stomatology, Anhui Medical University, Hefei 230000, People’s Republic of ChinaCorrespondence: Hai Ming WongFaculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Hong Kong, SAR 999077, People’s Republic of ChinaTel +852 28590261Fax +852 25593803Email wonghmg@hku.hkQuan Li LiCollege and Hospital of Stomatology, Anhui Medical University, No. 69, Meishan Road, Hefei 230000, People’s Republic of ChinaEmail ql-li@126.comAbstract: Dental plaque is one type of biofouling on the tooth surface that consists of a diverse population of microorganisms and extracellular matrix and causes oral diseases and even systematic diseases. Numerous studies have focused on preventing bacteria and proteins on tooth surfaces, especially with anti-biofouling coatings. Anti-biofouling coatings can be stable and sustainable over the long term on the tooth surface in the complex oral environment. In this review, numerous anti-biofouling coatings on the tooth surface and hydroxyapatite (as the main component of dental hard tissue) were summarized based on their mechanisms, which include three major strategies: antiprotein and antibacterial adhesion through chemical modification, contact killing through the modification of antimicrobial agents, and antibacterial agent release. The first strategy of coatings can resist the adsorption of proteins and bacteria. However, these coatings use passive strategies and cannot kill bacteria. The second strategy can interact with the cell membrane of bacteria to cause bacterial death. Due to the possibility of delivering a high antibacterial agent concentration locally, the third strategy is recommended and will be the trend of local drug use in dentistry in the future.Keywords: anti-biofouling coating, antibacterial agent, hydroxyapatite, tooth surface, binding
format	article
author	Zhou L Wong HM Li QL
author_facet	Zhou L Wong HM Li QL
author_sort	Zhou L
title	Anti-Biofouling Coatings on the Tooth Surface and Hydroxyapatite
title_short	Anti-Biofouling Coatings on the Tooth Surface and Hydroxyapatite
title_full	Anti-Biofouling Coatings on the Tooth Surface and Hydroxyapatite
title_fullStr	Anti-Biofouling Coatings on the Tooth Surface and Hydroxyapatite
title_full_unstemmed	Anti-Biofouling Coatings on the Tooth Surface and Hydroxyapatite
title_sort	anti-biofouling coatings on the tooth surface and hydroxyapatite
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/4206c8a4c67945518eb3afeca2881d7f
work_keys_str_mv	AT zhoul antibiofoulingcoatingsonthetoothsurfaceandhydroxyapatite AT wonghm antibiofoulingcoatingsonthetoothsurfaceandhydroxyapatite AT liql antibiofoulingcoatingsonthetoothsurfaceandhydroxyapatite
_version_	1718388640160153600

Anti-Biofouling Coatings on the Tooth Surface and Hydroxyapatite

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