Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy

Yuping Wei,1 Liang Ma,2 Liang Zhang,1,2 Xia Xu2 1State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 2School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan, Anhui, People’s Republic of Ch...

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Autores principales:	Wei YP, Ma L, Zhang L, Xu X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	paclitaxel drug delivery cell penetrating peptide anticancer therapy molecular simulations Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4206cf71f5e143dfb5b01eb4876aab94
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spelling	oai:doaj.org-article:4206cf71f5e143dfb5b01eb4876aab942021-12-02T01:46:42ZNoncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy1178-2013https://doaj.org/article/4206cf71f5e143dfb5b01eb4876aab942017-09-01T00:00:00Zhttps://www.dovepress.com/noncovalent-interaction-assisted-drug-delivery-system-with-highly-effi-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yuping Wei,1 Liang Ma,2 Liang Zhang,1,2 Xia Xu2 1State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 2School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan, Anhui, People’s Republic of China Abstract: An effective drug delivery system requires efficient drug uptake and release inside cancer cells. Here, we report a novel drug delivery system, in which paclitaxel (PTX) interacts with a novel cell penetrating peptide (CPP) through noncovalent interaction designed based on molecular simulations. This CPP/PTX complex confers high efficiency in delivering PTX into cancer cells not by endocytosis but by an energy-independent pathway. Once inside cells, the noncovalent interaction between PTX and the CPP may allow fast release of PTX within cells due to the direct translocation of CPP/PTX. This drug delivery system exhibits strong capacity for inhibition of tumor growth and offers a new avenue for the development of advanced drug delivery systems for anticancer therapy. Keywords: paclitaxel, drug delivery, cell penetrating peptide, anticancer therapy, molecular simulationsWei YPMa LZhang LXu XDove Medical Pressarticlepaclitaxeldrug deliverycell penetrating peptideanticancer therapymolecular simulationsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 7039-7051 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	paclitaxel drug delivery cell penetrating peptide anticancer therapy molecular simulations Medicine (General) R5-920
spellingShingle	paclitaxel drug delivery cell penetrating peptide anticancer therapy molecular simulations Medicine (General) R5-920 Wei YP Ma L Zhang L Xu X Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy
description	Yuping Wei,1 Liang Ma,2 Liang Zhang,1,2 Xia Xu2 1State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 2School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan, Anhui, People’s Republic of China Abstract: An effective drug delivery system requires efficient drug uptake and release inside cancer cells. Here, we report a novel drug delivery system, in which paclitaxel (PTX) interacts with a novel cell penetrating peptide (CPP) through noncovalent interaction designed based on molecular simulations. This CPP/PTX complex confers high efficiency in delivering PTX into cancer cells not by endocytosis but by an energy-independent pathway. Once inside cells, the noncovalent interaction between PTX and the CPP may allow fast release of PTX within cells due to the direct translocation of CPP/PTX. This drug delivery system exhibits strong capacity for inhibition of tumor growth and offers a new avenue for the development of advanced drug delivery systems for anticancer therapy. Keywords: paclitaxel, drug delivery, cell penetrating peptide, anticancer therapy, molecular simulations
format	article
author	Wei YP Ma L Zhang L Xu X
author_facet	Wei YP Ma L Zhang L Xu X
author_sort	Wei YP
title	Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy
title_short	Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy
title_full	Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy
title_fullStr	Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy
title_full_unstemmed	Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy
title_sort	noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/4206cf71f5e143dfb5b01eb4876aab94
work_keys_str_mv	AT weiyp noncovalentinteractionassisteddrugdeliverysystemwithhighlyefficientuptakeandreleaseofpaclitaxelforanticancertherapy AT mal noncovalentinteractionassisteddrugdeliverysystemwithhighlyefficientuptakeandreleaseofpaclitaxelforanticancertherapy AT zhangl noncovalentinteractionassisteddrugdeliverysystemwithhighlyefficientuptakeandreleaseofpaclitaxelforanticancertherapy AT xux noncovalentinteractionassisteddrugdeliverysystemwithhighlyefficientuptakeandreleaseofpaclitaxelforanticancertherapy
_version_	1718402890479960064

Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy

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