Increased NRG1-ErbB4 signaling in human symptomatic epilepsy

Abstract Previous studies have shown that the neuregulin 1 (NRG1)-ErbB4 signaling pathway may regulate the excitability of fast-spiking neurons in the frontal cortex and participate in primary epilepsy pathogenesis. However, the exact roles and mechanism for NRG1/ErbB4 in human symptomatic epilepsy...

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Autores principales:	Jun-Ming Zhu, Ke-Xin Li, Shu-Xia Cao, Xiao-Juan Chen, Chen-Jie Shen, Ying Zhang, Hong-Yan Geng, Bi-Qing Chen, Hong Lian, Jian-Min Zhang, Xiao-Ming Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/420724930bfd4bf49c99a6881c10b50e
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spelling	oai:doaj.org-article:420724930bfd4bf49c99a6881c10b50e2021-12-02T11:52:19ZIncreased NRG1-ErbB4 signaling in human symptomatic epilepsy10.1038/s41598-017-00207-72045-2322https://doaj.org/article/420724930bfd4bf49c99a6881c10b50e2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00207-7https://doaj.org/toc/2045-2322Abstract Previous studies have shown that the neuregulin 1 (NRG1)-ErbB4 signaling pathway may regulate the excitability of fast-spiking neurons in the frontal cortex and participate in primary epilepsy pathogenesis. However, the exact roles and mechanism for NRG1/ErbB4 in human symptomatic epilepsy are still unclear. Using fresh human symptomatic epilepsy tissues, we found that the protein levels of NRG1 and ErbB4 were significantly increased in the temporal cortex. In addition, NRG1-ErbB4 signaling suppressed phosphorylation of GluN2B at position 1472 by Src kinase, and decreased levels of phosphorylation level of GluN2B and Src were detected in human symptomatic epilepsy tissues. Our study revealed a critical role of the NRG1-ErbB4 signaling pathway in symptomatic epilepsy, which is different from that in primary epilepsy, and we propose that the NRG1-ErbB4 signaling may act as a homeostasis modulator that protects the brain from aggravation of epileptiform activity.Jun-Ming ZhuKe-Xin LiShu-Xia CaoXiao-Juan ChenChen-Jie ShenYing ZhangHong-Yan GengBi-Qing ChenHong LianJian-Min ZhangXiao-Ming LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jun-Ming Zhu Ke-Xin Li Shu-Xia Cao Xiao-Juan Chen Chen-Jie Shen Ying Zhang Hong-Yan Geng Bi-Qing Chen Hong Lian Jian-Min Zhang Xiao-Ming Li Increased NRG1-ErbB4 signaling in human symptomatic epilepsy
description	Abstract Previous studies have shown that the neuregulin 1 (NRG1)-ErbB4 signaling pathway may regulate the excitability of fast-spiking neurons in the frontal cortex and participate in primary epilepsy pathogenesis. However, the exact roles and mechanism for NRG1/ErbB4 in human symptomatic epilepsy are still unclear. Using fresh human symptomatic epilepsy tissues, we found that the protein levels of NRG1 and ErbB4 were significantly increased in the temporal cortex. In addition, NRG1-ErbB4 signaling suppressed phosphorylation of GluN2B at position 1472 by Src kinase, and decreased levels of phosphorylation level of GluN2B and Src were detected in human symptomatic epilepsy tissues. Our study revealed a critical role of the NRG1-ErbB4 signaling pathway in symptomatic epilepsy, which is different from that in primary epilepsy, and we propose that the NRG1-ErbB4 signaling may act as a homeostasis modulator that protects the brain from aggravation of epileptiform activity.
format	article
author	Jun-Ming Zhu Ke-Xin Li Shu-Xia Cao Xiao-Juan Chen Chen-Jie Shen Ying Zhang Hong-Yan Geng Bi-Qing Chen Hong Lian Jian-Min Zhang Xiao-Ming Li
author_facet	Jun-Ming Zhu Ke-Xin Li Shu-Xia Cao Xiao-Juan Chen Chen-Jie Shen Ying Zhang Hong-Yan Geng Bi-Qing Chen Hong Lian Jian-Min Zhang Xiao-Ming Li
author_sort	Jun-Ming Zhu
title	Increased NRG1-ErbB4 signaling in human symptomatic epilepsy
title_short	Increased NRG1-ErbB4 signaling in human symptomatic epilepsy
title_full	Increased NRG1-ErbB4 signaling in human symptomatic epilepsy
title_fullStr	Increased NRG1-ErbB4 signaling in human symptomatic epilepsy
title_full_unstemmed	Increased NRG1-ErbB4 signaling in human symptomatic epilepsy
title_sort	increased nrg1-erbb4 signaling in human symptomatic epilepsy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/420724930bfd4bf49c99a6881c10b50e
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Increased NRG1-ErbB4 signaling in human symptomatic epilepsy

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