A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules
Bacterial allosteric transcription factors can sense and respond to a variety of small molecules. Here the authors present CaT-SMelor which uses Cas12a and allosteric transcription factors to detect small molecules in the nanomolar range.
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Nature Portfolio
2019
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oai:doaj.org-article:4207fa0937a94606979b5c111fae58fa2021-12-02T16:50:59ZA CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules10.1038/s41467-019-11648-12041-1723https://doaj.org/article/4207fa0937a94606979b5c111fae58fa2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11648-1https://doaj.org/toc/2041-1723Bacterial allosteric transcription factors can sense and respond to a variety of small molecules. Here the authors present CaT-SMelor which uses Cas12a and allosteric transcription factors to detect small molecules in the nanomolar range.Mindong LiangZilong LiWeishan WangJiakun LiuLeshi LiuGuoliang ZhuLoganathan KarthikMan WangKe-Feng WangZhong WangJing YuYuting ShuaiJiaming YuLu ZhangZhiheng YangChuan LiQian ZhangTong ShiLiming ZhouFeng XieHuanqin DaiXueting LiuJingyu ZhangGuang LiuYing ZhuoBuchang ZhangChenli LiuShanshan LiXuekui XiaYaojun TongYanwen LiuGil AlterovitzGao-Yi TanLi-Xin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mindong Liang Zilong Li Weishan Wang Jiakun Liu Leshi Liu Guoliang Zhu Loganathan Karthik Man Wang Ke-Feng Wang Zhong Wang Jing Yu Yuting Shuai Jiaming Yu Lu Zhang Zhiheng Yang Chuan Li Qian Zhang Tong Shi Liming Zhou Feng Xie Huanqin Dai Xueting Liu Jingyu Zhang Guang Liu Ying Zhuo Buchang Zhang Chenli Liu Shanshan Li Xuekui Xia Yaojun Tong Yanwen Liu Gil Alterovitz Gao-Yi Tan Li-Xin Zhang A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules |
| description |
Bacterial allosteric transcription factors can sense and respond to a variety of small molecules. Here the authors present CaT-SMelor which uses Cas12a and allosteric transcription factors to detect small molecules in the nanomolar range. |
| format |
article |
| author |
Mindong Liang Zilong Li Weishan Wang Jiakun Liu Leshi Liu Guoliang Zhu Loganathan Karthik Man Wang Ke-Feng Wang Zhong Wang Jing Yu Yuting Shuai Jiaming Yu Lu Zhang Zhiheng Yang Chuan Li Qian Zhang Tong Shi Liming Zhou Feng Xie Huanqin Dai Xueting Liu Jingyu Zhang Guang Liu Ying Zhuo Buchang Zhang Chenli Liu Shanshan Li Xuekui Xia Yaojun Tong Yanwen Liu Gil Alterovitz Gao-Yi Tan Li-Xin Zhang |
| author_facet |
Mindong Liang Zilong Li Weishan Wang Jiakun Liu Leshi Liu Guoliang Zhu Loganathan Karthik Man Wang Ke-Feng Wang Zhong Wang Jing Yu Yuting Shuai Jiaming Yu Lu Zhang Zhiheng Yang Chuan Li Qian Zhang Tong Shi Liming Zhou Feng Xie Huanqin Dai Xueting Liu Jingyu Zhang Guang Liu Ying Zhuo Buchang Zhang Chenli Liu Shanshan Li Xuekui Xia Yaojun Tong Yanwen Liu Gil Alterovitz Gao-Yi Tan Li-Xin Zhang |
| author_sort |
Mindong Liang |
| title |
A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules |
| title_short |
A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules |
| title_full |
A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules |
| title_fullStr |
A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules |
| title_full_unstemmed |
A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules |
| title_sort |
crispr-cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4207fa0937a94606979b5c111fae58fa |
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