Acute necrotizing pancreatitis as a manifestation of Behcet’s Disease: A case report and review of the literature

Background: Behçet’s disease (BD) is a chronic, relapsing, multisystemic vasculitis with varying frequency of gastrointestinal manifestations. Pancreatitis is a rare manifestation of BD. Case presentation: A 31-year-old man diagnosed with Behçet’s disease with a fiveyear history of recurrent orogeni...

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Autores principales:	Geilan A. Mahmoud, Sally S. Mohamed, Nesma S. Abd El-Malek, Hania S. Zayed
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Behçet’s disease Pancreatitis Vasculitis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/420c17e3ef7c4376b419d4fd4599dc02
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spelling	oai:doaj.org-article:420c17e3ef7c4376b419d4fd4599dc022021-11-26T04:24:26ZAcute necrotizing pancreatitis as a manifestation of Behcet’s Disease: A case report and review of the literature1110-116410.1016/j.ejr.2021.11.003https://doaj.org/article/420c17e3ef7c4376b419d4fd4599dc022022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1110116421001009https://doaj.org/toc/1110-1164Background: Behçet’s disease (BD) is a chronic, relapsing, multisystemic vasculitis with varying frequency of gastrointestinal manifestations. Pancreatitis is a rare manifestation of BD. Case presentation: A 31-year-old man diagnosed with Behçet’s disease with a fiveyear history of recurrent orogenital ulcers, ocular involvement and pseudofolliculitis presented with severe epigastric pain radiating to back that worsens after meals and weight loss (10 kg in 3 months). He denied history of abdominal trauma, drug abuse or alcohol consumption. He was found to be hypertensive. Laboratory investigations revealed presence of leukocytosis, thrombocytosis, high inflammatory markers, low serum albumin, impaired renal functions, hyperglycemia and elevated serum amylase. Post contrast triphasic computed tomography scan showed a picture of necrotizing hemorrhagic pancreatitis. Bile and pancreatic ducts were normal. CT mesenteric angiography showed no evidence of aortic, celiac or superior mesenteric artery aneurysms, also splenic artery and veins were patent with no evidence of occlusion. After exclusion of other causes of acute pancreatitis, the condition has been attributed to BD. High dose of oral corticosteroids was started (60 mg/day) in addition to proper hydration, antihypertensive medications, intravenous antibiotics and insulin to control elevated blood sugar. Cystogastrostomy through endoscopic ultrasound was done to relieve the patient’s pain. Unfortunately, three months after the onset of pain, the patient developed systemic inflammatory response syndrome and passed away. Conclusion: Although acute pancreatitis is a rare gastrointestinal manifestation of BD, it is a possibly fatal one.Geilan A. MahmoudSally S. MohamedNesma S. Abd El-MalekHania S. ZayedElsevierarticleBehçet’s diseasePancreatitisVasculitisImmunologic diseases. AllergyRC581-607ENEgyptian Rheumatologist, Vol 44, Iss 2, Pp 165-169 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Behçet’s disease Pancreatitis Vasculitis Immunologic diseases. Allergy RC581-607
spellingShingle	Behçet’s disease Pancreatitis Vasculitis Immunologic diseases. Allergy RC581-607 Geilan A. Mahmoud Sally S. Mohamed Nesma S. Abd El-Malek Hania S. Zayed Acute necrotizing pancreatitis as a manifestation of Behcet’s Disease: A case report and review of the literature
description	Background: Behçet’s disease (BD) is a chronic, relapsing, multisystemic vasculitis with varying frequency of gastrointestinal manifestations. Pancreatitis is a rare manifestation of BD. Case presentation: A 31-year-old man diagnosed with Behçet’s disease with a fiveyear history of recurrent orogenital ulcers, ocular involvement and pseudofolliculitis presented with severe epigastric pain radiating to back that worsens after meals and weight loss (10 kg in 3 months). He denied history of abdominal trauma, drug abuse or alcohol consumption. He was found to be hypertensive. Laboratory investigations revealed presence of leukocytosis, thrombocytosis, high inflammatory markers, low serum albumin, impaired renal functions, hyperglycemia and elevated serum amylase. Post contrast triphasic computed tomography scan showed a picture of necrotizing hemorrhagic pancreatitis. Bile and pancreatic ducts were normal. CT mesenteric angiography showed no evidence of aortic, celiac or superior mesenteric artery aneurysms, also splenic artery and veins were patent with no evidence of occlusion. After exclusion of other causes of acute pancreatitis, the condition has been attributed to BD. High dose of oral corticosteroids was started (60 mg/day) in addition to proper hydration, antihypertensive medications, intravenous antibiotics and insulin to control elevated blood sugar. Cystogastrostomy through endoscopic ultrasound was done to relieve the patient’s pain. Unfortunately, three months after the onset of pain, the patient developed systemic inflammatory response syndrome and passed away. Conclusion: Although acute pancreatitis is a rare gastrointestinal manifestation of BD, it is a possibly fatal one.
format	article
author	Geilan A. Mahmoud Sally S. Mohamed Nesma S. Abd El-Malek Hania S. Zayed
author_facet	Geilan A. Mahmoud Sally S. Mohamed Nesma S. Abd El-Malek Hania S. Zayed
author_sort	Geilan A. Mahmoud
title	Acute necrotizing pancreatitis as a manifestation of Behcet’s Disease: A case report and review of the literature
title_short	Acute necrotizing pancreatitis as a manifestation of Behcet’s Disease: A case report and review of the literature
title_full	Acute necrotizing pancreatitis as a manifestation of Behcet’s Disease: A case report and review of the literature
title_fullStr	Acute necrotizing pancreatitis as a manifestation of Behcet’s Disease: A case report and review of the literature
title_full_unstemmed	Acute necrotizing pancreatitis as a manifestation of Behcet’s Disease: A case report and review of the literature
title_sort	acute necrotizing pancreatitis as a manifestation of behcet’s disease: a case report and review of the literature
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/420c17e3ef7c4376b419d4fd4599dc02
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Acute necrotizing pancreatitis as a manifestation of Behcet’s Disease: A case report and review of the literature

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