The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research

Yu-Long Lan,1– 3 Yongjian Zhu,1 Gao Chen,1 Jianmin Zhang1 1Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, People’s...

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Autores principales:	Lan YL, Zhu Y, Chen G, Zhang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	traumatic brain injury glioma promotion mechanism Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/420ec0525eb64170ace0e2794dda7277
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spelling	oai:doaj.org-article:420ec0525eb64170ace0e2794dda72772021-12-02T16:16:10ZThe Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research1178-7031https://doaj.org/article/420ec0525eb64170ace0e2794dda72772021-08-01T00:00:00Zhttps://www.dovepress.com/the-promoting-effect-of-traumatic-brain-injury-on-the-incidence-and-pr-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Yu-Long Lan,1– 3 Yongjian Zhu,1 Gao Chen,1 Jianmin Zhang1 1Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China; 3Department of Neurosurgery, Shenzhen People’s Hospital, Shenzhen, People’s Republic of ChinaCorrespondence: Yu-Long LanDepartment of Neurosurgery, Second Affiliated Hospital, School of medicine, Zhejiang University, Hangzhou, 310000, People’s Republic of ChinaTel +86 18858195203Email lanyulong@zju.edu.cnJianmin ZhangDepartment of Neurosurgery, Second Affiliated Hospital, School of medicine, Zhejiang University, Hangzhou, 310000, People’s Republic of ChinaTel +86 13805722695Email zjm135@zju.edu.cnAbstract: The role of traumatic brain injury in the development of glioma is highly controversial since first presented. This is not unexpected because traumatic brain injuries are overwhelmingly more common than glioma. However, the causes of post-traumatic glioma have been long discussed and still warrant further research. In this review, we have presented an overview of previous cohort studies and case–control studies. We have summarized the roles of microglial cells, macrophages, astrocytes, and stem cells in post-traumatic glioma formation and development, and reviewed various carcinogenic factors involved during traumatic brain injury, especially those reported in experimental studies indicating a relationship with glioma progression. Besides, traumatic brain injury and glioma share several common pathways, including inflammation and oxidative stress; however, the exact mechanism underlying this co-occurrence is yet to be discovered. In this review, we have summarized current epidemiological studies, clinical reports, pathophysiological research, as well as investigations evaluating the probable causes of co-occurrence and treatment possibilities. More efforts should be directed toward elucidating the relationship between traumatic brain injury and glioma, which could likely lead to promising pharmacological interventions towards designing therapeutic strategies.Keywords: traumatic brain injury, glioma, promotion, mechanismLan YLZhu YChen GZhang JDove Medical Pressarticletraumatic brain injurygliomapromotionmechanismPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 3707-3720 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	traumatic brain injury glioma promotion mechanism Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	traumatic brain injury glioma promotion mechanism Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Lan YL Zhu Y Chen G Zhang J The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research
description	Yu-Long Lan,1– 3 Yongjian Zhu,1 Gao Chen,1 Jianmin Zhang1 1Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China; 3Department of Neurosurgery, Shenzhen People’s Hospital, Shenzhen, People’s Republic of ChinaCorrespondence: Yu-Long LanDepartment of Neurosurgery, Second Affiliated Hospital, School of medicine, Zhejiang University, Hangzhou, 310000, People’s Republic of ChinaTel +86 18858195203Email lanyulong@zju.edu.cnJianmin ZhangDepartment of Neurosurgery, Second Affiliated Hospital, School of medicine, Zhejiang University, Hangzhou, 310000, People’s Republic of ChinaTel +86 13805722695Email zjm135@zju.edu.cnAbstract: The role of traumatic brain injury in the development of glioma is highly controversial since first presented. This is not unexpected because traumatic brain injuries are overwhelmingly more common than glioma. However, the causes of post-traumatic glioma have been long discussed and still warrant further research. In this review, we have presented an overview of previous cohort studies and case–control studies. We have summarized the roles of microglial cells, macrophages, astrocytes, and stem cells in post-traumatic glioma formation and development, and reviewed various carcinogenic factors involved during traumatic brain injury, especially those reported in experimental studies indicating a relationship with glioma progression. Besides, traumatic brain injury and glioma share several common pathways, including inflammation and oxidative stress; however, the exact mechanism underlying this co-occurrence is yet to be discovered. In this review, we have summarized current epidemiological studies, clinical reports, pathophysiological research, as well as investigations evaluating the probable causes of co-occurrence and treatment possibilities. More efforts should be directed toward elucidating the relationship between traumatic brain injury and glioma, which could likely lead to promising pharmacological interventions towards designing therapeutic strategies.Keywords: traumatic brain injury, glioma, promotion, mechanism
format	article
author	Lan YL Zhu Y Chen G Zhang J
author_facet	Lan YL Zhu Y Chen G Zhang J
author_sort	Lan YL
title	The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research
title_short	The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research
title_full	The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research
title_fullStr	The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research
title_full_unstemmed	The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research
title_sort	promoting effect of traumatic brain injury on the incidence and progression of glioma: a review of clinical and experimental research
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/420ec0525eb64170ace0e2794dda7277
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The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research

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