Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery

Xudong Hu,1,&ast; Bing Luo,2,&ast; Qing Wu,2 Qingbiao Chen,2 Penghui Lu,2 Jie Huang,3 Xiaoxia Liang,1 Cheng Ling,1 Yiqun Li2 1Department of Anesthesiology, The Second People’s Hospital of Foshan, Foshan, Guangdong, 528000, People’s Republic of China; 2Department of Surgery, The Second People...

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Autores principales:	Hu X, Luo B, Wu Q, Chen Q, Lu P, Huang J, Liang X, Ling C, Li Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	dezocine sufentanil vas th1/th2 balance breast cancer Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/4212382799244d1aa9b5030754b78744
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id	oai:doaj.org-article:4212382799244d1aa9b5030754b78744
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spelling	oai:doaj.org-article:4212382799244d1aa9b5030754b787442021-12-02T19:17:36ZEffects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery1177-8881https://doaj.org/article/4212382799244d1aa9b5030754b787442021-12-01T00:00:00Zhttps://www.dovepress.com/effects-of-dezocine-and-sufentanil-on-th1th2-balance-in-breast-cancer--peer-reviewed-fulltext-article-DDDThttps://doaj.org/toc/1177-8881Xudong Hu,1,&ast; Bing Luo,2,&ast; Qing Wu,2 Qingbiao Chen,2 Penghui Lu,2 Jie Huang,3 Xiaoxia Liang,1 Cheng Ling,1 Yiqun Li2 1Department of Anesthesiology, The Second People’s Hospital of Foshan, Foshan, Guangdong, 528000, People’s Republic of China; 2Department of Surgery, The Second People’s Hospital of Foshan, Foshan, Guangdong, 528000, People’s Republic of China; 3Clinical Laboratory, The Second People’s Hospital of Foshan, Foshan, Guangdong, 528000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yiqun LiDepartment of Surgery, The Second People’s Hospital of Foshan, No. 78 Weiguo Road, Foshan, Guangdong, 528000, People’s Republic of ChinaTel +86 13902845621Fax +86 75788032008Email yiqunlide03@163.comBackground: It is very important for breast cancer patients undergoing surgery to choose an opioid that has little effect on the immune system. The aim of this study is to compare the effects of dezocine or sufentanil on postoperative pain and Th1/Th2 balance in patients undergoing breast cancer surgery.Methods: Data from 92 breast cancer patients from January 2019 to July 2020 at Foshan Second People’s Hospital (Guangdong, China) were analyzed. Sufentanil (SF) was used in group SF (n = 44) and dezocine (DE) in group DE (n = 48). The Visual Analog Scale (VAS) scores were assessed, and the percentages of Th1 cells and Th2 cells in peripheral blood were detected before anesthesia and at 2, 12, 24, and 48 hours after surgery.Results: There was no significant difference in the VAS scores between the two groups at 2, 24, and 48 hours after surgery (P > 0.05). The VAS scores at 12 hours after surgery in group DE were significantly lower than those in group SF with a statistically significant difference (P < 0.05). The percentage of Th1 cells in group DE at 2, 12, 24, and 48 hours after surgery was significantly lower than that in group SF (P < 0.05). The percentage of Th2 cells in group DE at 2, 12, 24, and 48 hours after surgery was significantly lower than that in group SF (P < 0.05). The Th1/Th2 ratio at 2, 12, 24, and 48 hours after surgery was significantly higher in group DE than that in group SF (P < 0.05).Conclusion: Dezocine for anesthesia induction and postoperative analgesia can maintain the balance of Th1/Th2 more stable than, with the same analgesia efficacy as, sufentanil during the early postoperative period in breast cancer patients undergoing surgery.Keywords: dezocine, sufentanil, VAS, Th1/Th2 balance, breast cancerHu XLuo BWu QChen QLu PHuang JLiang XLing CLi YDove Medical Pressarticledezocinesufentanilvasth1/th2 balancebreast cancerTherapeutics. PharmacologyRM1-950ENDrug Design, Development and Therapy, Vol Volume 15, Pp 4925-4938 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dezocine sufentanil vas th1/th2 balance breast cancer Therapeutics. Pharmacology RM1-950
spellingShingle	dezocine sufentanil vas th1/th2 balance breast cancer Therapeutics. Pharmacology RM1-950 Hu X Luo B Wu Q Chen Q Lu P Huang J Liang X Ling C Li Y Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery
description	Xudong Hu,1,&ast; Bing Luo,2,&ast; Qing Wu,2 Qingbiao Chen,2 Penghui Lu,2 Jie Huang,3 Xiaoxia Liang,1 Cheng Ling,1 Yiqun Li2 1Department of Anesthesiology, The Second People’s Hospital of Foshan, Foshan, Guangdong, 528000, People’s Republic of China; 2Department of Surgery, The Second People’s Hospital of Foshan, Foshan, Guangdong, 528000, People’s Republic of China; 3Clinical Laboratory, The Second People’s Hospital of Foshan, Foshan, Guangdong, 528000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yiqun LiDepartment of Surgery, The Second People’s Hospital of Foshan, No. 78 Weiguo Road, Foshan, Guangdong, 528000, People’s Republic of ChinaTel +86 13902845621Fax +86 75788032008Email yiqunlide03@163.comBackground: It is very important for breast cancer patients undergoing surgery to choose an opioid that has little effect on the immune system. The aim of this study is to compare the effects of dezocine or sufentanil on postoperative pain and Th1/Th2 balance in patients undergoing breast cancer surgery.Methods: Data from 92 breast cancer patients from January 2019 to July 2020 at Foshan Second People’s Hospital (Guangdong, China) were analyzed. Sufentanil (SF) was used in group SF (n = 44) and dezocine (DE) in group DE (n = 48). The Visual Analog Scale (VAS) scores were assessed, and the percentages of Th1 cells and Th2 cells in peripheral blood were detected before anesthesia and at 2, 12, 24, and 48 hours after surgery.Results: There was no significant difference in the VAS scores between the two groups at 2, 24, and 48 hours after surgery (P > 0.05). The VAS scores at 12 hours after surgery in group DE were significantly lower than those in group SF with a statistically significant difference (P < 0.05). The percentage of Th1 cells in group DE at 2, 12, 24, and 48 hours after surgery was significantly lower than that in group SF (P < 0.05). The percentage of Th2 cells in group DE at 2, 12, 24, and 48 hours after surgery was significantly lower than that in group SF (P < 0.05). The Th1/Th2 ratio at 2, 12, 24, and 48 hours after surgery was significantly higher in group DE than that in group SF (P < 0.05).Conclusion: Dezocine for anesthesia induction and postoperative analgesia can maintain the balance of Th1/Th2 more stable than, with the same analgesia efficacy as, sufentanil during the early postoperative period in breast cancer patients undergoing surgery.Keywords: dezocine, sufentanil, VAS, Th1/Th2 balance, breast cancer
format	article
author	Hu X Luo B Wu Q Chen Q Lu P Huang J Liang X Ling C Li Y
author_facet	Hu X Luo B Wu Q Chen Q Lu P Huang J Liang X Ling C Li Y
author_sort	Hu X
title	Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery
title_short	Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery
title_full	Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery
title_fullStr	Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery
title_full_unstemmed	Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery
title_sort	effects of dezocine and sufentanil on th1/th2 balance in breast cancer patients undergoing surgery
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/4212382799244d1aa9b5030754b78744
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Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery

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