Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia

Abstract Oral iron promotes intestinal tumourigenesis in animal models. In humans, expression of iron transport proteins are altered in colorectal cancer. This study examined whether the route of iron therapy alters iron transport and tumour growth. Colorectal adenocarcinoma patients with pre-operat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hafid O. Al-Hassi, Oliver Ng, Rayko Evstatiev, Manel Mangalika, Natalie Worton, Manuela Jambrich, Vineeta Khare, Oliver Phipps, Barrie Keeler, Christoph Gasche, Austin G. Acheson, Matthew J. Brookes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/421c6c1e64334c10b8d8919f20611200
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:421c6c1e64334c10b8d8919f20611200
record_format	dspace
spelling	oai:doaj.org-article:421c6c1e64334c10b8d8919f206112002021-12-02T18:18:51ZIntravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia10.1038/s41598-021-93155-22045-2322https://doaj.org/article/421c6c1e64334c10b8d8919f206112002021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93155-2https://doaj.org/toc/2045-2322Abstract Oral iron promotes intestinal tumourigenesis in animal models. In humans, expression of iron transport proteins are altered in colorectal cancer. This study examined whether the route of iron therapy alters iron transport and tumour growth. Colorectal adenocarcinoma patients with pre-operative iron deficiency anaemia received oral ferrous sulphate (n = 15), or intravenous ferric carboxymaltose (n = 15). Paired (normal and tumour tissues) samples were compared for expression of iron loading, iron transporters, proliferation, apoptosis and Wnt signalling using immunohistochemistry and RT-PCR. Iron loading was increased in tumour and distributed to the stroma in intravenous treatment and to the epithelium in oral treatment. Protein and mRNA expression of proliferation and iron transporters were increased in tumours compared to normal tissues but there were no significant differences between the treatment groups. However, intravenous iron treatment reduced ferritin mRNA levels in tumours and replenished body iron stores. Iron distribution to non-epithelial cells in intravenous iron suggests that iron is less bioavailable to tumour cells. Therefore, intravenous iron may be a better option in the treatment of colorectal cancer patients with iron deficiency anaemia due to its efficiency in replenishing iron levels while its effect on proliferation and iron metabolism is similar to that of oral iron treatment.Hafid O. Al-HassiOliver NgRayko EvstatievManel MangalikaNatalie WortonManuela JambrichVineeta KhareOliver PhippsBarrie KeelerChristoph GascheAustin G. AchesonMatthew J. BrookesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hafid O. Al-Hassi Oliver Ng Rayko Evstatiev Manel Mangalika Natalie Worton Manuela Jambrich Vineeta Khare Oliver Phipps Barrie Keeler Christoph Gasche Austin G. Acheson Matthew J. Brookes Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia
description	Abstract Oral iron promotes intestinal tumourigenesis in animal models. In humans, expression of iron transport proteins are altered in colorectal cancer. This study examined whether the route of iron therapy alters iron transport and tumour growth. Colorectal adenocarcinoma patients with pre-operative iron deficiency anaemia received oral ferrous sulphate (n = 15), or intravenous ferric carboxymaltose (n = 15). Paired (normal and tumour tissues) samples were compared for expression of iron loading, iron transporters, proliferation, apoptosis and Wnt signalling using immunohistochemistry and RT-PCR. Iron loading was increased in tumour and distributed to the stroma in intravenous treatment and to the epithelium in oral treatment. Protein and mRNA expression of proliferation and iron transporters were increased in tumours compared to normal tissues but there were no significant differences between the treatment groups. However, intravenous iron treatment reduced ferritin mRNA levels in tumours and replenished body iron stores. Iron distribution to non-epithelial cells in intravenous iron suggests that iron is less bioavailable to tumour cells. Therefore, intravenous iron may be a better option in the treatment of colorectal cancer patients with iron deficiency anaemia due to its efficiency in replenishing iron levels while its effect on proliferation and iron metabolism is similar to that of oral iron treatment.
format	article
author	Hafid O. Al-Hassi Oliver Ng Rayko Evstatiev Manel Mangalika Natalie Worton Manuela Jambrich Vineeta Khare Oliver Phipps Barrie Keeler Christoph Gasche Austin G. Acheson Matthew J. Brookes
author_facet	Hafid O. Al-Hassi Oliver Ng Rayko Evstatiev Manel Mangalika Natalie Worton Manuela Jambrich Vineeta Khare Oliver Phipps Barrie Keeler Christoph Gasche Austin G. Acheson Matthew J. Brookes
author_sort	Hafid O. Al-Hassi
title	Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia
title_short	Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia
title_full	Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia
title_fullStr	Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia
title_full_unstemmed	Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia
title_sort	intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/421c6c1e64334c10b8d8919f20611200
work_keys_str_mv	AT hafidoalhassi intravenousironisnoninferiortooralironregardingcellgrowthandironmetabolismincolorectalcancerassociatedwithirondeficiencyanaemia AT oliverng intravenousironisnoninferiortooralironregardingcellgrowthandironmetabolismincolorectalcancerassociatedwithirondeficiencyanaemia AT raykoevstatiev intravenousironisnoninferiortooralironregardingcellgrowthandironmetabolismincolorectalcancerassociatedwithirondeficiencyanaemia AT manelmangalika intravenousironisnoninferiortooralironregardingcellgrowthandironmetabolismincolorectalcancerassociatedwithirondeficiencyanaemia AT natalieworton intravenousironisnoninferiortooralironregardingcellgrowthandironmetabolismincolorectalcancerassociatedwithirondeficiencyanaemia AT manuelajambrich intravenousironisnoninferiortooralironregardingcellgrowthandironmetabolismincolorectalcancerassociatedwithirondeficiencyanaemia AT vineetakhare intravenousironisnoninferiortooralironregardingcellgrowthandironmetabolismincolorectalcancerassociatedwithirondeficiencyanaemia AT oliverphipps intravenousironisnoninferiortooralironregardingcellgrowthandironmetabolismincolorectalcancerassociatedwithirondeficiencyanaemia AT barriekeeler intravenousironisnoninferiortooralironregardingcellgrowthandironmetabolismincolorectalcancerassociatedwithirondeficiencyanaemia AT christophgasche intravenousironisnoninferiortooralironregardingcellgrowthandironmetabolismincolorectalcancerassociatedwithirondeficiencyanaemia AT austingacheson intravenousironisnoninferiortooralironregardingcellgrowthandironmetabolismincolorectalcancerassociatedwithirondeficiencyanaemia AT matthewjbrookes intravenousironisnoninferiortooralironregardingcellgrowthandironmetabolismincolorectalcancerassociatedwithirondeficiencyanaemia
_version_	1718378150444924928

Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia

Ejemplares similares