Selectivity of mRNA degradation by autophagy in yeast

Autophagic degradation of proteins and organelles is well studied, but the role of autophagy in RNA regulation is unclear. Here, the authors profile mRNAs targeted to the vacuole in yeast and observe autophagy-mediated mRNA degradation is not random but rather is a preferential process.

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Detalles Bibliográficos
Autores principales: Shiho Makino, Tomoko Kawamata, Shintaro Iwasaki, Yoshinori Ohsumi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/421dd11f73434bc1bdbdf632a13eda6f
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Sumario:Autophagic degradation of proteins and organelles is well studied, but the role of autophagy in RNA regulation is unclear. Here, the authors profile mRNAs targeted to the vacuole in yeast and observe autophagy-mediated mRNA degradation is not random but rather is a preferential process.