Microfluidic-Chip-Integrated Biosensors for Lung Disease Models

Lung diseases (e.g., infection, asthma, cancer, and pulmonary fibrosis) represent serious threats to human health all over the world. Conventional two-dimensional (2D) cell models and animal models cannot mimic the human-specific properties of the lungs. In the past decade, human organ-on-a-chip (OO...

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Autores principales:	Shuang Ding, Haijun Zhang, Xuemei Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biosensor microfluidics organ-on-a-chip lung model lung-on-a-chip Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/421e8c23c4bc42b89a793bf825a0372e
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id	oai:doaj.org-article:421e8c23c4bc42b89a793bf825a0372e
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spelling	oai:doaj.org-article:421e8c23c4bc42b89a793bf825a0372e2021-11-25T16:55:38ZMicrofluidic-Chip-Integrated Biosensors for Lung Disease Models10.3390/bios111104562079-6374https://doaj.org/article/421e8c23c4bc42b89a793bf825a0372e2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6374/11/11/456https://doaj.org/toc/2079-6374Lung diseases (e.g., infection, asthma, cancer, and pulmonary fibrosis) represent serious threats to human health all over the world. Conventional two-dimensional (2D) cell models and animal models cannot mimic the human-specific properties of the lungs. In the past decade, human organ-on-a-chip (OOC) platforms—including lung-on-a-chip (LOC)—have emerged rapidly, with the ability to reproduce the in vivo features of organs or tissues based on their three-dimensional (3D) structures. Furthermore, the integration of biosensors in the chip allows researchers to monitor various parameters related to disease development and drug efficacy. In this review, we illustrate the biosensor-based LOC modeling, further discussing the future challenges as well as perspectives in integrating biosensors in OOC platforms.Shuang DingHaijun ZhangXuemei WangMDPI AGarticlebiosensormicrofluidicsorgan-on-a-chiplung modellung-on-a-chipBiotechnologyTP248.13-248.65ENBiosensors, Vol 11, Iss 456, p 456 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biosensor microfluidics organ-on-a-chip lung model lung-on-a-chip Biotechnology TP248.13-248.65
spellingShingle	biosensor microfluidics organ-on-a-chip lung model lung-on-a-chip Biotechnology TP248.13-248.65 Shuang Ding Haijun Zhang Xuemei Wang Microfluidic-Chip-Integrated Biosensors for Lung Disease Models
description	Lung diseases (e.g., infection, asthma, cancer, and pulmonary fibrosis) represent serious threats to human health all over the world. Conventional two-dimensional (2D) cell models and animal models cannot mimic the human-specific properties of the lungs. In the past decade, human organ-on-a-chip (OOC) platforms—including lung-on-a-chip (LOC)—have emerged rapidly, with the ability to reproduce the in vivo features of organs or tissues based on their three-dimensional (3D) structures. Furthermore, the integration of biosensors in the chip allows researchers to monitor various parameters related to disease development and drug efficacy. In this review, we illustrate the biosensor-based LOC modeling, further discussing the future challenges as well as perspectives in integrating biosensors in OOC platforms.
format	article
author	Shuang Ding Haijun Zhang Xuemei Wang
author_facet	Shuang Ding Haijun Zhang Xuemei Wang
author_sort	Shuang Ding
title	Microfluidic-Chip-Integrated Biosensors for Lung Disease Models
title_short	Microfluidic-Chip-Integrated Biosensors for Lung Disease Models
title_full	Microfluidic-Chip-Integrated Biosensors for Lung Disease Models
title_fullStr	Microfluidic-Chip-Integrated Biosensors for Lung Disease Models
title_full_unstemmed	Microfluidic-Chip-Integrated Biosensors for Lung Disease Models
title_sort	microfluidic-chip-integrated biosensors for lung disease models
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/421e8c23c4bc42b89a793bf825a0372e
work_keys_str_mv	AT shuangding microfluidicchipintegratedbiosensorsforlungdiseasemodels AT haijunzhang microfluidicchipintegratedbiosensorsforlungdiseasemodels AT xuemeiwang microfluidicchipintegratedbiosensorsforlungdiseasemodels
_version_	1718412833671086080

Microfluidic-Chip-Integrated Biosensors for Lung Disease Models

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