The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review

Autoantibodies to multiple cytokines have been identified and some, including antibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF), have been associated with increased susceptibility to infection. High levels of GM-CSF autoantibodies that neutralize signaling cause autoimmune...

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Autores principales:	Ali Ataya, Vijaya Knight, Brenna C. Carey, Elinor Lee, Elizabeth J. Tarling, Tisha Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	autoantibodies autoimmune pulmonary alveolar proteinosis sargramostim Nocardia Cryptococcus Aspergillus Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/421e8c5a8d954e5abbc5404e63fbe51c
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spelling	oai:doaj.org-article:421e8c5a8d954e5abbc5404e63fbe51c2021-11-22T11:39:31ZThe Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review1664-322410.3389/fimmu.2021.752856https://doaj.org/article/421e8c5a8d954e5abbc5404e63fbe51c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.752856/fullhttps://doaj.org/toc/1664-3224Autoantibodies to multiple cytokines have been identified and some, including antibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF), have been associated with increased susceptibility to infection. High levels of GM-CSF autoantibodies that neutralize signaling cause autoimmune pulmonary alveolar proteinosis (aPAP), an ultrarare autoimmune disease characterized by accumulation of excess surfactant in the alveoli, leading to pulmonary insufficiency. Defective GM-CSF signaling leads to functional deficits in multiple cell types, including macrophages and neutrophils, with impaired phagocytosis and host immune responses against pulmonary and systemic infections. In this article, we review the role of GM-CSF in aPAP pathogenesis and pulmonary homeostasis along with the increased incidence of infections (particularly opportunistic infections). Therefore, recombinant human GM-CSF products may have potential for treatment of aPAP and possibly other infectious and pulmonary diseases due to its pleotropic immunomodulatory actions.Ali AtayaVijaya KnightBrenna C. CareyElinor LeeElizabeth J. TarlingTisha WangFrontiers Media S.A.articleautoantibodiesautoimmune pulmonary alveolar proteinosissargramostimNocardiaCryptococcusAspergillusImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autoantibodies autoimmune pulmonary alveolar proteinosis sargramostim Nocardia Cryptococcus Aspergillus Immunologic diseases. Allergy RC581-607
spellingShingle	autoantibodies autoimmune pulmonary alveolar proteinosis sargramostim Nocardia Cryptococcus Aspergillus Immunologic diseases. Allergy RC581-607 Ali Ataya Vijaya Knight Brenna C. Carey Elinor Lee Elizabeth J. Tarling Tisha Wang The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review
description	Autoantibodies to multiple cytokines have been identified and some, including antibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF), have been associated with increased susceptibility to infection. High levels of GM-CSF autoantibodies that neutralize signaling cause autoimmune pulmonary alveolar proteinosis (aPAP), an ultrarare autoimmune disease characterized by accumulation of excess surfactant in the alveoli, leading to pulmonary insufficiency. Defective GM-CSF signaling leads to functional deficits in multiple cell types, including macrophages and neutrophils, with impaired phagocytosis and host immune responses against pulmonary and systemic infections. In this article, we review the role of GM-CSF in aPAP pathogenesis and pulmonary homeostasis along with the increased incidence of infections (particularly opportunistic infections). Therefore, recombinant human GM-CSF products may have potential for treatment of aPAP and possibly other infectious and pulmonary diseases due to its pleotropic immunomodulatory actions.
format	article
author	Ali Ataya Vijaya Knight Brenna C. Carey Elinor Lee Elizabeth J. Tarling Tisha Wang
author_facet	Ali Ataya Vijaya Knight Brenna C. Carey Elinor Lee Elizabeth J. Tarling Tisha Wang
author_sort	Ali Ataya
title	The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review
title_short	The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review
title_full	The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review
title_fullStr	The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review
title_full_unstemmed	The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review
title_sort	role of gm-csf autoantibodies in infection and autoimmune pulmonary alveolar proteinosis: a concise review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/421e8c5a8d954e5abbc5404e63fbe51c
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The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review

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