Association of serum bilirubin levels with risk of cancer development and total death

Abstract Serum levels of bilirubin, a strong antioxidant, may influence cancer risk. We aimed to assess the association between serum bilirubin levels and cancer risk. Data were retrieved from 10-year electronic medical records at Kyushu University Hospital (Japan) for patients aged 20 to 69 years o...

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Autores principales:	Toyoshi Inoguchi, Yasunobu Nohara, Chinatsu Nojiri, Naoki Nakashima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/421ea89ab80c4a29b80f257089634263
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spelling	oai:doaj.org-article:421ea89ab80c4a29b80f2570896342632021-12-02T17:44:54ZAssociation of serum bilirubin levels with risk of cancer development and total death10.1038/s41598-021-92442-22045-2322https://doaj.org/article/421ea89ab80c4a29b80f2570896342632021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92442-2https://doaj.org/toc/2045-2322Abstract Serum levels of bilirubin, a strong antioxidant, may influence cancer risk. We aimed to assess the association between serum bilirubin levels and cancer risk. Data were retrieved from 10-year electronic medical records at Kyushu University Hospital (Japan) for patients aged 20 to 69 years old. The associations of baseline bilirubin levels with cancer risk (lung, colon, breast, prostate, and cervical) were evaluated using a gradient boosting decision tree (GBDT) model, a machine learning algorithm, and Cox proportional hazard regression model, adjusted for age, smoking, body mass index, and diabetes. The number of study subjects was 29,080. Median follow-up time was 4.7 years. GBDT models illustrated that baseline bilirubin levels were negatively and non-linearly associated with the risk of lung (men), colon, and cervical cancer. In contrast, a U-shaped association was observed for breast and prostate cancer. Cox hazard regression analyses confirmed that baseline bilirubin levels (< 1.2 mg/dL) were negatively associated with lung cancer risk in men (HR = 0.474, 95% CI 0.271–0.828, P = 0.009) and cervical cancer risk (HR = 0.365, 95% CI 0.136–0.977, P = 0.045). Additionally, low bilirubin levels (< 0.6 mg/dL) were associated with total death (HR = 1.744, 95% CI 1.369–2.222, P < 0.001). Serum bilirubin may have a beneficial effect on the risk of some types of cancers.Toyoshi InoguchiYasunobu NoharaChinatsu NojiriNaoki NakashimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Toyoshi Inoguchi Yasunobu Nohara Chinatsu Nojiri Naoki Nakashima Association of serum bilirubin levels with risk of cancer development and total death
description	Abstract Serum levels of bilirubin, a strong antioxidant, may influence cancer risk. We aimed to assess the association between serum bilirubin levels and cancer risk. Data were retrieved from 10-year electronic medical records at Kyushu University Hospital (Japan) for patients aged 20 to 69 years old. The associations of baseline bilirubin levels with cancer risk (lung, colon, breast, prostate, and cervical) were evaluated using a gradient boosting decision tree (GBDT) model, a machine learning algorithm, and Cox proportional hazard regression model, adjusted for age, smoking, body mass index, and diabetes. The number of study subjects was 29,080. Median follow-up time was 4.7 years. GBDT models illustrated that baseline bilirubin levels were negatively and non-linearly associated with the risk of lung (men), colon, and cervical cancer. In contrast, a U-shaped association was observed for breast and prostate cancer. Cox hazard regression analyses confirmed that baseline bilirubin levels (< 1.2 mg/dL) were negatively associated with lung cancer risk in men (HR = 0.474, 95% CI 0.271–0.828, P = 0.009) and cervical cancer risk (HR = 0.365, 95% CI 0.136–0.977, P = 0.045). Additionally, low bilirubin levels (< 0.6 mg/dL) were associated with total death (HR = 1.744, 95% CI 1.369–2.222, P < 0.001). Serum bilirubin may have a beneficial effect on the risk of some types of cancers.
format	article
author	Toyoshi Inoguchi Yasunobu Nohara Chinatsu Nojiri Naoki Nakashima
author_facet	Toyoshi Inoguchi Yasunobu Nohara Chinatsu Nojiri Naoki Nakashima
author_sort	Toyoshi Inoguchi
title	Association of serum bilirubin levels with risk of cancer development and total death
title_short	Association of serum bilirubin levels with risk of cancer development and total death
title_full	Association of serum bilirubin levels with risk of cancer development and total death
title_fullStr	Association of serum bilirubin levels with risk of cancer development and total death
title_full_unstemmed	Association of serum bilirubin levels with risk of cancer development and total death
title_sort	association of serum bilirubin levels with risk of cancer development and total death
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/421ea89ab80c4a29b80f257089634263
work_keys_str_mv	AT toyoshiinoguchi associationofserumbilirubinlevelswithriskofcancerdevelopmentandtotaldeath AT yasunobunohara associationofserumbilirubinlevelswithriskofcancerdevelopmentandtotaldeath AT chinatsunojiri associationofserumbilirubinlevelswithriskofcancerdevelopmentandtotaldeath AT naokinakashima associationofserumbilirubinlevelswithriskofcancerdevelopmentandtotaldeath
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Association of serum bilirubin levels with risk of cancer development and total death

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