Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects

Drugs targeting dysregulated ERK1/2 signaling can cause severe cardiac side effects, precluding their wide therapeutic application. Here, a new and cardio-safe targeting strategy is presented that interferes with ERK dimerization to prevent pathological ERK1/2 signaling in the heart and cancer.

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Autores principales: Angela Tomasovic, Theresa Brand, Constanze Schanbacher, Sofia Kramer, Martin W. Hümmert, Patricio Godoy, Wolfgang Schmidt-Heck, Peter Nordbeck, Jonas Ludwig, Susanne Homann, Armin Wiegering, Timur Shaykhutdinov, Christoph Kratz, Ruth Knüchel, Hans-Konrad Müller-Hermelink, Andreas Rosenwald, Norbert Frey, Jutta Eichler, Dobromir Dobrev, Ali El-Armouche, Jan G. Hengstler, Oliver J. Müller, Karsten Hinrichs, Friederike Cuello, Alma Zernecke, Kristina Lorenz
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Publicado: Nature Portfolio 2020
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spelling oai:doaj.org-article:422072e270cd48449067eb1413f577cb2021-12-02T17:32:13ZInterference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects10.1038/s41467-020-15505-42041-1723https://doaj.org/article/422072e270cd48449067eb1413f577cb2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15505-4https://doaj.org/toc/2041-1723Drugs targeting dysregulated ERK1/2 signaling can cause severe cardiac side effects, precluding their wide therapeutic application. Here, a new and cardio-safe targeting strategy is presented that interferes with ERK dimerization to prevent pathological ERK1/2 signaling in the heart and cancer.Angela TomasovicTheresa BrandConstanze SchanbacherSofia KramerMartin W. HümmertPatricio GodoyWolfgang Schmidt-HeckPeter NordbeckJonas LudwigSusanne HomannArmin WiegeringTimur ShaykhutdinovChristoph KratzRuth KnüchelHans-Konrad Müller-HermelinkAndreas RosenwaldNorbert FreyJutta EichlerDobromir DobrevAli El-ArmoucheJan G. HengstlerOliver J. MüllerKarsten HinrichsFriederike CuelloAlma ZerneckeKristina LorenzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Angela Tomasovic
Theresa Brand
Constanze Schanbacher
Sofia Kramer
Martin W. Hümmert
Patricio Godoy
Wolfgang Schmidt-Heck
Peter Nordbeck
Jonas Ludwig
Susanne Homann
Armin Wiegering
Timur Shaykhutdinov
Christoph Kratz
Ruth Knüchel
Hans-Konrad Müller-Hermelink
Andreas Rosenwald
Norbert Frey
Jutta Eichler
Dobromir Dobrev
Ali El-Armouche
Jan G. Hengstler
Oliver J. Müller
Karsten Hinrichs
Friederike Cuello
Alma Zernecke
Kristina Lorenz
Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects
description Drugs targeting dysregulated ERK1/2 signaling can cause severe cardiac side effects, precluding their wide therapeutic application. Here, a new and cardio-safe targeting strategy is presented that interferes with ERK dimerization to prevent pathological ERK1/2 signaling in the heart and cancer.
format article
author Angela Tomasovic
Theresa Brand
Constanze Schanbacher
Sofia Kramer
Martin W. Hümmert
Patricio Godoy
Wolfgang Schmidt-Heck
Peter Nordbeck
Jonas Ludwig
Susanne Homann
Armin Wiegering
Timur Shaykhutdinov
Christoph Kratz
Ruth Knüchel
Hans-Konrad Müller-Hermelink
Andreas Rosenwald
Norbert Frey
Jutta Eichler
Dobromir Dobrev
Ali El-Armouche
Jan G. Hengstler
Oliver J. Müller
Karsten Hinrichs
Friederike Cuello
Alma Zernecke
Kristina Lorenz
author_facet Angela Tomasovic
Theresa Brand
Constanze Schanbacher
Sofia Kramer
Martin W. Hümmert
Patricio Godoy
Wolfgang Schmidt-Heck
Peter Nordbeck
Jonas Ludwig
Susanne Homann
Armin Wiegering
Timur Shaykhutdinov
Christoph Kratz
Ruth Knüchel
Hans-Konrad Müller-Hermelink
Andreas Rosenwald
Norbert Frey
Jutta Eichler
Dobromir Dobrev
Ali El-Armouche
Jan G. Hengstler
Oliver J. Müller
Karsten Hinrichs
Friederike Cuello
Alma Zernecke
Kristina Lorenz
author_sort Angela Tomasovic
title Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects
title_short Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects
title_full Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects
title_fullStr Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects
title_full_unstemmed Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects
title_sort interference with erk-dimerization at the nucleocytosolic interface targets pathological erk1/2 signaling without cardiotoxic side-effects
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/422072e270cd48449067eb1413f577cb
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