Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects
Drugs targeting dysregulated ERK1/2 signaling can cause severe cardiac side effects, precluding their wide therapeutic application. Here, a new and cardio-safe targeting strategy is presented that interferes with ERK dimerization to prevent pathological ERK1/2 signaling in the heart and cancer.
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2020
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oai:doaj.org-article:422072e270cd48449067eb1413f577cb2021-12-02T17:32:13ZInterference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects10.1038/s41467-020-15505-42041-1723https://doaj.org/article/422072e270cd48449067eb1413f577cb2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15505-4https://doaj.org/toc/2041-1723Drugs targeting dysregulated ERK1/2 signaling can cause severe cardiac side effects, precluding their wide therapeutic application. Here, a new and cardio-safe targeting strategy is presented that interferes with ERK dimerization to prevent pathological ERK1/2 signaling in the heart and cancer.Angela TomasovicTheresa BrandConstanze SchanbacherSofia KramerMartin W. HümmertPatricio GodoyWolfgang Schmidt-HeckPeter NordbeckJonas LudwigSusanne HomannArmin WiegeringTimur ShaykhutdinovChristoph KratzRuth KnüchelHans-Konrad Müller-HermelinkAndreas RosenwaldNorbert FreyJutta EichlerDobromir DobrevAli El-ArmoucheJan G. HengstlerOliver J. MüllerKarsten HinrichsFriederike CuelloAlma ZerneckeKristina LorenzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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Science Q Angela Tomasovic Theresa Brand Constanze Schanbacher Sofia Kramer Martin W. Hümmert Patricio Godoy Wolfgang Schmidt-Heck Peter Nordbeck Jonas Ludwig Susanne Homann Armin Wiegering Timur Shaykhutdinov Christoph Kratz Ruth Knüchel Hans-Konrad Müller-Hermelink Andreas Rosenwald Norbert Frey Jutta Eichler Dobromir Dobrev Ali El-Armouche Jan G. Hengstler Oliver J. Müller Karsten Hinrichs Friederike Cuello Alma Zernecke Kristina Lorenz Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects |
description |
Drugs targeting dysregulated ERK1/2 signaling can cause severe cardiac side effects, precluding their wide therapeutic application. Here, a new and cardio-safe targeting strategy is presented that interferes with ERK dimerization to prevent pathological ERK1/2 signaling in the heart and cancer. |
format |
article |
author |
Angela Tomasovic Theresa Brand Constanze Schanbacher Sofia Kramer Martin W. Hümmert Patricio Godoy Wolfgang Schmidt-Heck Peter Nordbeck Jonas Ludwig Susanne Homann Armin Wiegering Timur Shaykhutdinov Christoph Kratz Ruth Knüchel Hans-Konrad Müller-Hermelink Andreas Rosenwald Norbert Frey Jutta Eichler Dobromir Dobrev Ali El-Armouche Jan G. Hengstler Oliver J. Müller Karsten Hinrichs Friederike Cuello Alma Zernecke Kristina Lorenz |
author_facet |
Angela Tomasovic Theresa Brand Constanze Schanbacher Sofia Kramer Martin W. Hümmert Patricio Godoy Wolfgang Schmidt-Heck Peter Nordbeck Jonas Ludwig Susanne Homann Armin Wiegering Timur Shaykhutdinov Christoph Kratz Ruth Knüchel Hans-Konrad Müller-Hermelink Andreas Rosenwald Norbert Frey Jutta Eichler Dobromir Dobrev Ali El-Armouche Jan G. Hengstler Oliver J. Müller Karsten Hinrichs Friederike Cuello Alma Zernecke Kristina Lorenz |
author_sort |
Angela Tomasovic |
title |
Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects |
title_short |
Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects |
title_full |
Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects |
title_fullStr |
Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects |
title_full_unstemmed |
Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects |
title_sort |
interference with erk-dimerization at the nucleocytosolic interface targets pathological erk1/2 signaling without cardiotoxic side-effects |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/422072e270cd48449067eb1413f577cb |
work_keys_str_mv |
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