TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance.

Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune reactions. While TREM-1-amplified responses likely aid an improved detection and elimination of pathogens, excessive production of cytokines and oxygen radicals can also severely harm th...

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Autores principales:	Benjamin Weber, Steffen Schuster, Daniel Zysset, Silvia Rihs, Nina Dickgreber, Christian Schürch, Carsten Riether, Mark Siegrist, Christoph Schneider, Helga Pawelski, Ursina Gurzeler, Pascal Ziltener, Vera Genitsch, Fabienne Tacchini-Cottier, Adrian Ochsenbein, Willy Hofstetter, Manfred Kopf, Thomas Kaufmann, Annette Oxenius, Walter Reith, Leslie Saurer, Christoph Mueller
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/42262ea844a64ff3b8f92dc971b3e0fb
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TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance.

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