m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis

Ime4p is a yeast N6-methyladenosine (m6A) methyltransferase with an unknown role in meiosis. Rme1p is a repressor of meiosis. Here the authors show that Ime4p methylates RME1 3′ UTR to reduce its expression and enable meiosis, thus providing an example of an m6A site with a physiological role.

Guardado en:

Detalles Bibliográficos
Autores principales:	G. Guy Bushkin, David Pincus, Jeffrey T. Morgan, Kris Richardson, Caroline Lewis, Sze Ham Chan, David P. Bartel, Gerald R. Fink
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4227ec2b4c764d77808e435df040b4f0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4227ec2b4c764d77808e435df040b4f0
record_format	dspace
spelling	oai:doaj.org-article:4227ec2b4c764d77808e435df040b4f02021-12-02T17:32:56Zm6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis10.1038/s41467-019-11232-72041-1723https://doaj.org/article/4227ec2b4c764d77808e435df040b4f02019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11232-7https://doaj.org/toc/2041-1723Ime4p is a yeast N6-methyladenosine (m6A) methyltransferase with an unknown role in meiosis. Rme1p is a repressor of meiosis. Here the authors show that Ime4p methylates RME1 3′ UTR to reduce its expression and enable meiosis, thus providing an example of an m6A site with a physiological role.G. Guy BushkinDavid PincusJeffrey T. MorganKris RichardsonCaroline LewisSze Ham ChanDavid P. BartelGerald R. FinkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q G. Guy Bushkin David Pincus Jeffrey T. Morgan Kris Richardson Caroline Lewis Sze Ham Chan David P. Bartel Gerald R. Fink m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis
description	Ime4p is a yeast N6-methyladenosine (m6A) methyltransferase with an unknown role in meiosis. Rme1p is a repressor of meiosis. Here the authors show that Ime4p methylates RME1 3′ UTR to reduce its expression and enable meiosis, thus providing an example of an m6A site with a physiological role.
format	article
author	G. Guy Bushkin David Pincus Jeffrey T. Morgan Kris Richardson Caroline Lewis Sze Ham Chan David P. Bartel Gerald R. Fink
author_facet	G. Guy Bushkin David Pincus Jeffrey T. Morgan Kris Richardson Caroline Lewis Sze Ham Chan David P. Bartel Gerald R. Fink
author_sort	G. Guy Bushkin
title	m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis
title_short	m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis
title_full	m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis
title_fullStr	m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis
title_full_unstemmed	m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis
title_sort	m6a modification of a 3′ utr site reduces rme1 mrna levels to promote meiosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4227ec2b4c764d77808e435df040b4f0
work_keys_str_mv	AT gguybushkin m6amodificationofa3utrsitereducesrme1mrnalevelstopromotemeiosis AT davidpincus m6amodificationofa3utrsitereducesrme1mrnalevelstopromotemeiosis AT jeffreytmorgan m6amodificationofa3utrsitereducesrme1mrnalevelstopromotemeiosis AT krisrichardson m6amodificationofa3utrsitereducesrme1mrnalevelstopromotemeiosis AT carolinelewis m6amodificationofa3utrsitereducesrme1mrnalevelstopromotemeiosis AT szehamchan m6amodificationofa3utrsitereducesrme1mrnalevelstopromotemeiosis AT davidpbartel m6amodificationofa3utrsitereducesrme1mrnalevelstopromotemeiosis AT geraldrfink m6amodificationofa3utrsitereducesrme1mrnalevelstopromotemeiosis
_version_	1718380115241467904

m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis

Ejemplares similares