m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis

m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis

Ime4p is a yeast N6-methyladenosine (m6A) methyltransferase with an unknown role in meiosis. Rme1p is a repressor of meiosis. Here the authors show that Ime4p methylates RME1 3′ UTR to reduce its expression and enable meiosis, thus providing an example of an m6A site with a physiological role.

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Autores principales: G. Guy Bushkin, David Pincus, Jeffrey T. Morgan, Kris Richardson, Caroline Lewis, Sze Ham Chan, David P. Bartel, Gerald R. Fink
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/4227ec2b4c764d77808e435df040b4f0
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