A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation

A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation

DNA 5-hydroxymethylcytosine (5hmC) modification is associated with gene transcription and used as a mark of mammalian development. Here the authors report a comprehensive 5hmC tissue map and analysis of 5hmC genomic distributions in 19 human tissues derived from 10 organ systems, thus providing insi...

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Autores principales: Xiao-Long Cui, Ji Nie, Jeremy Ku, Urszula Dougherty, Diana C. West-Szymanski, Francois Collin, Christopher K. Ellison, Laura Sieh, Yuhong Ning, Zifeng Deng, Carolyn W. T. Zhao, Anna Bergamaschi, Joel Pekow, Jiangbo Wei, Alana V. Beadell, Zhou Zhang, Geeta Sharma, Raman Talwar, Patrick Arensdorf, Jason Karpus, Ajay Goel, Marc Bissonnette, Wei Zhang, Samuel Levy, Chuan He
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/422a834f9ee54a78aa65900aafeb0d8b
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spelling oai:doaj.org-article:422a834f9ee54a78aa65900aafeb0d8b2021-12-02T14:41:26ZA human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation10.1038/s41467-020-20001-w2041-1723https://doaj.org/article/422a834f9ee54a78aa65900aafeb0d8b2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20001-whttps://doaj.org/toc/2041-1723DNA 5-hydroxymethylcytosine (5hmC) modification is associated with gene transcription and used as a mark of mammalian development. Here the authors report a comprehensive 5hmC tissue map and analysis of 5hmC genomic distributions in 19 human tissues derived from 10 organ systems, thus providing insights into the role of 5hmC in tissue-specific development.Xiao-Long CuiJi NieJeremy KuUrszula DoughertyDiana C. West-SzymanskiFrancois CollinChristopher K. EllisonLaura SiehYuhong NingZifeng DengCarolyn W. T. ZhaoAnna BergamaschiJoel PekowJiangbo WeiAlana V. BeadellZhou ZhangGeeta SharmaRaman TalwarPatrick ArensdorfJason KarpusAjay GoelMarc BissonnetteWei ZhangSamuel LevyChuan HeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiao-Long Cui
Ji Nie
Jeremy Ku
Urszula Dougherty
Diana C. West-Szymanski
Francois Collin
Christopher K. Ellison
Laura Sieh
Yuhong Ning
Zifeng Deng
Carolyn W. T. Zhao
Anna Bergamaschi
Joel Pekow
Jiangbo Wei
Alana V. Beadell
Zhou Zhang
Geeta Sharma
Raman Talwar
Patrick Arensdorf
Jason Karpus
Ajay Goel
Marc Bissonnette
Wei Zhang
Samuel Levy
Chuan He
A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation
description DNA 5-hydroxymethylcytosine (5hmC) modification is associated with gene transcription and used as a mark of mammalian development. Here the authors report a comprehensive 5hmC tissue map and analysis of 5hmC genomic distributions in 19 human tissues derived from 10 organ systems, thus providing insights into the role of 5hmC in tissue-specific development.
format article
author Xiao-Long Cui
Ji Nie
Jeremy Ku
Urszula Dougherty
Diana C. West-Szymanski
Francois Collin
Christopher K. Ellison
Laura Sieh
Yuhong Ning
Zifeng Deng
Carolyn W. T. Zhao
Anna Bergamaschi
Joel Pekow
Jiangbo Wei
Alana V. Beadell
Zhou Zhang
Geeta Sharma
Raman Talwar
Patrick Arensdorf
Jason Karpus
Ajay Goel
Marc Bissonnette
Wei Zhang
Samuel Levy
Chuan He
author_facet Xiao-Long Cui
Ji Nie
Jeremy Ku
Urszula Dougherty
Diana C. West-Szymanski
Francois Collin
Christopher K. Ellison
Laura Sieh
Yuhong Ning
Zifeng Deng
Carolyn W. T. Zhao
Anna Bergamaschi
Joel Pekow
Jiangbo Wei
Alana V. Beadell
Zhou Zhang
Geeta Sharma
Raman Talwar
Patrick Arensdorf
Jason Karpus
Ajay Goel
Marc Bissonnette
Wei Zhang
Samuel Levy
Chuan He
author_sort Xiao-Long Cui
title A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation
title_short A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation
title_full A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation
title_fullStr A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation
title_full_unstemmed A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation
title_sort human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/422a834f9ee54a78aa65900aafeb0d8b
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