Management of penile cancer in a Singapore tertiary hospital

Objectives: To present our experience of managing penile squamous cell carcinoma (SCC) in a tertiary hospital in Singapore and to evaluate the prognostic value of the inflammatory markers neutrophil–lymphocyte ratio (NLR) and lymphocyte–monocyte ratio (LMR). Patients and methods: We reviewed our pro...

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Autores principales:	Teck Wei Tan, Sing Joo Chia, Kian Tai Chong
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2017
Materias:	Inflammatory markers Inguinal Lymph node Penile cancer Penis Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/422c876ab53549698dfb93e02e234914
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spelling	oai:doaj.org-article:422c876ab53549698dfb93e02e2349142021-12-02T10:36:47ZManagement of penile cancer in a Singapore tertiary hospital2090-598X10.1016/j.aju.2017.03.001https://doaj.org/article/422c876ab53549698dfb93e02e2349142017-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X17300323https://doaj.org/toc/2090-598XObjectives: To present our experience of managing penile squamous cell carcinoma (SCC) in a tertiary hospital in Singapore and to evaluate the prognostic value of the inflammatory markers neutrophil–lymphocyte ratio (NLR) and lymphocyte–monocyte ratio (LMR). Patients and methods: We reviewed our prospectively maintained Institutional Review Board-approved urological cancer database to identify men treated for penile SCC at our centre between January 2007 and December 2015. For all the patients identified, we collected epidemiological and clinical data. Results: In all, 39 patients were identified who were treated for penile SCC in our centre. The median [interquartile range (IQR)] follow-up was 34 (16.5–66) months. Although very few (23%) of our patients with high-risk clinical node-negative underwent prophylactic inguinal lymph node dissection (ILND), they still had excellent 5-year recurrence-free survival (RFS; 90%) and cancer-specific survival (CSS; 90%). At multivariate analysis, higher N stage was significantly associated with worse RFS and CSS. Patients with a high NLR (≥2.8) had significantly higher T-stage (P = 0.006) and worse CSS (P < 0.001) than those with a low NLR. Patients with a low LMR (<3.3) had significantly higher T-stage (P = 0.013) and worse RFS (P = 0.009) and CSS (P < 0.022) than those with a high LMR. Conclusions: Although very few of our patients with intermediate- and high-risk clinical node-negative SCC underwent prophylactic ILND, they still had excellent 5-year RFS and CSS. However, survival was poor in patients with node-positive disease. The pre-treatment NLR and LMR could serve as biomarkers to predict the prognosis of patients with penile cancer.Teck Wei TanSing Joo ChiaKian Tai ChongTaylor & Francis GrouparticleInflammatory markersInguinalLymph nodePenile cancerPenisDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 15, Iss 2, Pp 123-130 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Inflammatory markers Inguinal Lymph node Penile cancer Penis Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Inflammatory markers Inguinal Lymph node Penile cancer Penis Diseases of the genitourinary system. Urology RC870-923 Teck Wei Tan Sing Joo Chia Kian Tai Chong Management of penile cancer in a Singapore tertiary hospital
description	Objectives: To present our experience of managing penile squamous cell carcinoma (SCC) in a tertiary hospital in Singapore and to evaluate the prognostic value of the inflammatory markers neutrophil–lymphocyte ratio (NLR) and lymphocyte–monocyte ratio (LMR). Patients and methods: We reviewed our prospectively maintained Institutional Review Board-approved urological cancer database to identify men treated for penile SCC at our centre between January 2007 and December 2015. For all the patients identified, we collected epidemiological and clinical data. Results: In all, 39 patients were identified who were treated for penile SCC in our centre. The median [interquartile range (IQR)] follow-up was 34 (16.5–66) months. Although very few (23%) of our patients with high-risk clinical node-negative underwent prophylactic inguinal lymph node dissection (ILND), they still had excellent 5-year recurrence-free survival (RFS; 90%) and cancer-specific survival (CSS; 90%). At multivariate analysis, higher N stage was significantly associated with worse RFS and CSS. Patients with a high NLR (≥2.8) had significantly higher T-stage (P = 0.006) and worse CSS (P < 0.001) than those with a low NLR. Patients with a low LMR (<3.3) had significantly higher T-stage (P = 0.013) and worse RFS (P = 0.009) and CSS (P < 0.022) than those with a high LMR. Conclusions: Although very few of our patients with intermediate- and high-risk clinical node-negative SCC underwent prophylactic ILND, they still had excellent 5-year RFS and CSS. However, survival was poor in patients with node-positive disease. The pre-treatment NLR and LMR could serve as biomarkers to predict the prognosis of patients with penile cancer.
format	article
author	Teck Wei Tan Sing Joo Chia Kian Tai Chong
author_facet	Teck Wei Tan Sing Joo Chia Kian Tai Chong
author_sort	Teck Wei Tan
title	Management of penile cancer in a Singapore tertiary hospital
title_short	Management of penile cancer in a Singapore tertiary hospital
title_full	Management of penile cancer in a Singapore tertiary hospital
title_fullStr	Management of penile cancer in a Singapore tertiary hospital
title_full_unstemmed	Management of penile cancer in a Singapore tertiary hospital
title_sort	management of penile cancer in a singapore tertiary hospital
publisher	Taylor & Francis Group
publishDate	2017
url	https://doaj.org/article/422c876ab53549698dfb93e02e234914
work_keys_str_mv	AT teckweitan managementofpenilecancerinasingaporetertiaryhospital AT singjoochia managementofpenilecancerinasingaporetertiaryhospital AT kiantaichong managementofpenilecancerinasingaporetertiaryhospital
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Management of penile cancer in a Singapore tertiary hospital

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