Hierarchical Modeling of the Liver Vascular System

The liver plays a key role in the metabolic homeostasis of the whole organism. To carry out its functions, it is endowed with a peculiar circulatory system, made of three main dendritic flow structures and lobules. Understanding the vascular anatomy of the liver is clinically relevant since various...

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Autores principales:	Aimee M. Torres Rojas, Sylvie Lorente, Mathieu Hautefeuille, Aczel Sanchez-Cedillo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	liver circulatory system constructal design small-for-size syndrome hepatectomy liver hemodynamic parameters Physiology QP1-981
Acceso en línea:	https://doaj.org/article/422ea8cffabb4566acdbe99c319efad5
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spelling	oai:doaj.org-article:422ea8cffabb4566acdbe99c319efad52021-11-16T07:47:51ZHierarchical Modeling of the Liver Vascular System1664-042X10.3389/fphys.2021.733165https://doaj.org/article/422ea8cffabb4566acdbe99c319efad52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.733165/fullhttps://doaj.org/toc/1664-042XThe liver plays a key role in the metabolic homeostasis of the whole organism. To carry out its functions, it is endowed with a peculiar circulatory system, made of three main dendritic flow structures and lobules. Understanding the vascular anatomy of the liver is clinically relevant since various liver pathologies are related to vascular disorders. Here, we develop a novel liver circulation model with a deterministic architecture based on the constructal law of design over the entire scale range (from macrocirculation to microcirculation). In this framework, the liver vascular structure is a combination of superimposed tree-shaped networks and porous system, where the main geometrical features of the dendritic fluid networks and the permeability of the porous medium, are defined from the constructal viewpoint. With this model, we are able to emulate physiological scenarios and to predict changes in blood pressure and flow rates throughout the hepatic vasculature due to resection or thrombosis in certain portions of the organ, simulated as deliberate blockages in the blood supply to these sections. This work sheds light on the critical impact of the vascular network on mechanics-related processes occurring in hepatic diseases, healing and regeneration that involve blood flow redistribution and are at the core of liver resilience.Aimee M. Torres RojasSylvie LorenteMathieu HautefeuilleAczel Sanchez-CedilloFrontiers Media S.A.articleliver circulatory systemconstructal designsmall-for-size syndromehepatectomyliver hemodynamic parametersPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liver circulatory system constructal design small-for-size syndrome hepatectomy liver hemodynamic parameters Physiology QP1-981
spellingShingle	liver circulatory system constructal design small-for-size syndrome hepatectomy liver hemodynamic parameters Physiology QP1-981 Aimee M. Torres Rojas Sylvie Lorente Mathieu Hautefeuille Aczel Sanchez-Cedillo Hierarchical Modeling of the Liver Vascular System
description	The liver plays a key role in the metabolic homeostasis of the whole organism. To carry out its functions, it is endowed with a peculiar circulatory system, made of three main dendritic flow structures and lobules. Understanding the vascular anatomy of the liver is clinically relevant since various liver pathologies are related to vascular disorders. Here, we develop a novel liver circulation model with a deterministic architecture based on the constructal law of design over the entire scale range (from macrocirculation to microcirculation). In this framework, the liver vascular structure is a combination of superimposed tree-shaped networks and porous system, where the main geometrical features of the dendritic fluid networks and the permeability of the porous medium, are defined from the constructal viewpoint. With this model, we are able to emulate physiological scenarios and to predict changes in blood pressure and flow rates throughout the hepatic vasculature due to resection or thrombosis in certain portions of the organ, simulated as deliberate blockages in the blood supply to these sections. This work sheds light on the critical impact of the vascular network on mechanics-related processes occurring in hepatic diseases, healing and regeneration that involve blood flow redistribution and are at the core of liver resilience.
format	article
author	Aimee M. Torres Rojas Sylvie Lorente Mathieu Hautefeuille Aczel Sanchez-Cedillo
author_facet	Aimee M. Torres Rojas Sylvie Lorente Mathieu Hautefeuille Aczel Sanchez-Cedillo
author_sort	Aimee M. Torres Rojas
title	Hierarchical Modeling of the Liver Vascular System
title_short	Hierarchical Modeling of the Liver Vascular System
title_full	Hierarchical Modeling of the Liver Vascular System
title_fullStr	Hierarchical Modeling of the Liver Vascular System
title_full_unstemmed	Hierarchical Modeling of the Liver Vascular System
title_sort	hierarchical modeling of the liver vascular system
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/422ea8cffabb4566acdbe99c319efad5
work_keys_str_mv	AT aimeemtorresrojas hierarchicalmodelingofthelivervascularsystem AT sylvielorente hierarchicalmodelingofthelivervascularsystem AT mathieuhautefeuille hierarchicalmodelingofthelivervascularsystem AT aczelsanchezcedillo hierarchicalmodelingofthelivervascularsystem
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Hierarchical Modeling of the Liver Vascular System

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