Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL

WUSCHEL is a homeodomain transcription factor that is essential for stem cell maintenance in the plant shoot apical meristem. Here, via structural and biochemical approaches, Sloan et al. show that strong WUSCHEL binding to preferential target motifs can be attributed to dimer formation that stabili...

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Autores principales:	Jeremy Sloan, Jana P. Hakenjos, Michael Gebert, Olga Ermakova, Andrea Gumiero, Gunter Stier, Klemens Wild, Irmgard Sinning, Jan U. Lohmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4236df3e1fb04bd8b5f3b137806f34a3
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spelling	oai:doaj.org-article:4236df3e1fb04bd8b5f3b137806f34a32021-12-02T17:31:24ZStructural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL10.1038/s41467-020-16024-y2041-1723https://doaj.org/article/4236df3e1fb04bd8b5f3b137806f34a32020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16024-yhttps://doaj.org/toc/2041-1723WUSCHEL is a homeodomain transcription factor that is essential for stem cell maintenance in the plant shoot apical meristem. Here, via structural and biochemical approaches, Sloan et al. show that strong WUSCHEL binding to preferential target motifs can be attributed to dimer formation that stabilizes DNA binding.Jeremy SloanJana P. HakenjosMichael GebertOlga ErmakovaAndrea GumieroGunter StierKlemens WildIrmgard SinningJan U. LohmannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeremy Sloan Jana P. Hakenjos Michael Gebert Olga Ermakova Andrea Gumiero Gunter Stier Klemens Wild Irmgard Sinning Jan U. Lohmann Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL
description	WUSCHEL is a homeodomain transcription factor that is essential for stem cell maintenance in the plant shoot apical meristem. Here, via structural and biochemical approaches, Sloan et al. show that strong WUSCHEL binding to preferential target motifs can be attributed to dimer formation that stabilizes DNA binding.
format	article
author	Jeremy Sloan Jana P. Hakenjos Michael Gebert Olga Ermakova Andrea Gumiero Gunter Stier Klemens Wild Irmgard Sinning Jan U. Lohmann
author_facet	Jeremy Sloan Jana P. Hakenjos Michael Gebert Olga Ermakova Andrea Gumiero Gunter Stier Klemens Wild Irmgard Sinning Jan U. Lohmann
author_sort	Jeremy Sloan
title	Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL
title_short	Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL
title_full	Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL
title_fullStr	Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL
title_full_unstemmed	Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL
title_sort	structural basis for the complex dna binding behavior of the plant stem cell regulator wuschel
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4236df3e1fb04bd8b5f3b137806f34a3
work_keys_str_mv	AT jeremysloan structuralbasisforthecomplexdnabindingbehavioroftheplantstemcellregulatorwuschel AT janaphakenjos structuralbasisforthecomplexdnabindingbehavioroftheplantstemcellregulatorwuschel AT michaelgebert structuralbasisforthecomplexdnabindingbehavioroftheplantstemcellregulatorwuschel AT olgaermakova structuralbasisforthecomplexdnabindingbehavioroftheplantstemcellregulatorwuschel AT andreagumiero structuralbasisforthecomplexdnabindingbehavioroftheplantstemcellregulatorwuschel AT gunterstier structuralbasisforthecomplexdnabindingbehavioroftheplantstemcellregulatorwuschel AT klemenswild structuralbasisforthecomplexdnabindingbehavioroftheplantstemcellregulatorwuschel AT irmgardsinning structuralbasisforthecomplexdnabindingbehavioroftheplantstemcellregulatorwuschel AT janulohmann structuralbasisforthecomplexdnabindingbehavioroftheplantstemcellregulatorwuschel
_version_	1718380608141393920

Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL

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