Knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD

Abstract The pathogenesis of chronic kidney disease (CKD) is multifactorial. In the progression of CKD arthropathy, arteriosclerosis may alter the knee subchondral bone marrow by altering blood flow through the bone vasculature. Herein, multi-parametric MRI assessment, including dynamic contrast enh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chao-Ying Wang, Yu-Juei Hsu, Yi-Jen Peng, Herng-Sheng Lee, Yue-Cune Chang, Chih-Shan Chang, Shih-Wei Chiang, Yi-Chih Hsu, Ming-Huang Lin, Guo-Shu Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/42374575fe524b8fa7a9740845760e0e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:42374575fe524b8fa7a9740845760e0e
record_format	dspace
spelling	oai:doaj.org-article:42374575fe524b8fa7a9740845760e0e2021-12-02T12:31:45ZKnee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD10.1038/s41598-017-03059-32045-2322https://doaj.org/article/42374575fe524b8fa7a9740845760e0e2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03059-3https://doaj.org/toc/2045-2322Abstract The pathogenesis of chronic kidney disease (CKD) is multifactorial. In the progression of CKD arthropathy, arteriosclerosis may alter the knee subchondral bone marrow by altering blood flow through the bone vasculature. Herein, multi-parametric MRI assessment, including dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), magnetic resonance spectroscopy (MRS), MRI T2*, contrast enhanced MR angiography (CE-MRA), and micro-CT were applied in a rodent nephrectomy model to: 1) investigate the blood perfusion of subchondral bone marrow and its relationship to fat water content and trabeculation pattern in CKD and 2) demonstrate the feasibility of using multi-parametric MRI parameters as imaging biomarkers to evaluate the disease’s progression. Two groups of rats in our study underwent either 1) no intervention or 2) 5/6 nephrectomy. We found that in the CKD group, perfusion amplitude A and elimination constant k el values were significantly decreased, and vascular permeability k ep was significantly increased. MRS showed that fat fraction (FF) was significantly lower, water fraction (WF) was significantly higher in the CKD group. Micro-CT showed a significant loss of trabecular bone. Knee subchondral bone marrow perfusion deficiency in experimental CKD may be associated with decreased fat content, increased water content, and sparse trabeculation.Chao-Ying WangYu-Juei HsuYi-Jen PengHerng-Sheng LeeYue-Cune ChangChih-Shan ChangShih-Wei ChiangYi-Chih HsuMing-Huang LinGuo-Shu HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chao-Ying Wang Yu-Juei Hsu Yi-Jen Peng Herng-Sheng Lee Yue-Cune Chang Chih-Shan Chang Shih-Wei Chiang Yi-Chih Hsu Ming-Huang Lin Guo-Shu Huang Knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD
description	Abstract The pathogenesis of chronic kidney disease (CKD) is multifactorial. In the progression of CKD arthropathy, arteriosclerosis may alter the knee subchondral bone marrow by altering blood flow through the bone vasculature. Herein, multi-parametric MRI assessment, including dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), magnetic resonance spectroscopy (MRS), MRI T2*, contrast enhanced MR angiography (CE-MRA), and micro-CT were applied in a rodent nephrectomy model to: 1) investigate the blood perfusion of subchondral bone marrow and its relationship to fat water content and trabeculation pattern in CKD and 2) demonstrate the feasibility of using multi-parametric MRI parameters as imaging biomarkers to evaluate the disease’s progression. Two groups of rats in our study underwent either 1) no intervention or 2) 5/6 nephrectomy. We found that in the CKD group, perfusion amplitude A and elimination constant k el values were significantly decreased, and vascular permeability k ep was significantly increased. MRS showed that fat fraction (FF) was significantly lower, water fraction (WF) was significantly higher in the CKD group. Micro-CT showed a significant loss of trabecular bone. Knee subchondral bone marrow perfusion deficiency in experimental CKD may be associated with decreased fat content, increased water content, and sparse trabeculation.
format	article
author	Chao-Ying Wang Yu-Juei Hsu Yi-Jen Peng Herng-Sheng Lee Yue-Cune Chang Chih-Shan Chang Shih-Wei Chiang Yi-Chih Hsu Ming-Huang Lin Guo-Shu Huang
author_facet	Chao-Ying Wang Yu-Juei Hsu Yi-Jen Peng Herng-Sheng Lee Yue-Cune Chang Chih-Shan Chang Shih-Wei Chiang Yi-Chih Hsu Ming-Huang Lin Guo-Shu Huang
author_sort	Chao-Ying Wang
title	Knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD
title_short	Knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD
title_full	Knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD
title_fullStr	Knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD
title_full_unstemmed	Knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD
title_sort	knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric mri and micro-ct in experimental ckd
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/42374575fe524b8fa7a9740845760e0e
work_keys_str_mv	AT chaoyingwang kneesubchondralboneperfusionanditsrelationshiptomarrowfatandtrabeculationonmultiparametricmriandmicroctinexperimentalckd AT yujueihsu kneesubchondralboneperfusionanditsrelationshiptomarrowfatandtrabeculationonmultiparametricmriandmicroctinexperimentalckd AT yijenpeng kneesubchondralboneperfusionanditsrelationshiptomarrowfatandtrabeculationonmultiparametricmriandmicroctinexperimentalckd AT herngshenglee kneesubchondralboneperfusionanditsrelationshiptomarrowfatandtrabeculationonmultiparametricmriandmicroctinexperimentalckd AT yuecunechang kneesubchondralboneperfusionanditsrelationshiptomarrowfatandtrabeculationonmultiparametricmriandmicroctinexperimentalckd AT chihshanchang kneesubchondralboneperfusionanditsrelationshiptomarrowfatandtrabeculationonmultiparametricmriandmicroctinexperimentalckd AT shihweichiang kneesubchondralboneperfusionanditsrelationshiptomarrowfatandtrabeculationonmultiparametricmriandmicroctinexperimentalckd AT yichihhsu kneesubchondralboneperfusionanditsrelationshiptomarrowfatandtrabeculationonmultiparametricmriandmicroctinexperimentalckd AT minghuanglin kneesubchondralboneperfusionanditsrelationshiptomarrowfatandtrabeculationonmultiparametricmriandmicroctinexperimentalckd AT guoshuhuang kneesubchondralboneperfusionanditsrelationshiptomarrowfatandtrabeculationonmultiparametricmriandmicroctinexperimentalckd
_version_	1718394273725939712

Knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD

Ejemplares similares