Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population

Adipose tissue is composed of a variety of cell types, including adipocyte precursor populations, that contribute to adipose tissue function upon differentiation. Here, using scRNA-sequencing of adolescent and adult mouse subcutaneous adipose tissue, the authors identify an Asc-1 positive preadipocy...

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Autores principales:	Lisa Suwandhi, Irem Altun, Ruth Karlina, Viktorian Miok, Tobias Wiedemann, David Fischer, Thomas Walzthoeni, Christina Lindner, Anika Böttcher, Silke S. Heinzmann, Andreas Israel, Ahmed Elagamy Mohamed Mahmoud Khalil, Alexander Braun, Ines Pramme-Steinwachs, Ingo Burtscher, Philippe Schmitt-Kopplin, Matthias Heinig, Martin Elsner, Heiko Lickert, Fabian J. Theis, Siegfried Ussar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4238107fca564fd486a026933c82d054
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spelling	oai:doaj.org-article:4238107fca564fd486a026933c82d0542021-12-02T13:32:51ZAsc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population10.1038/s41467-021-21826-92041-1723https://doaj.org/article/4238107fca564fd486a026933c82d0542021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21826-9https://doaj.org/toc/2041-1723Adipose tissue is composed of a variety of cell types, including adipocyte precursor populations, that contribute to adipose tissue function upon differentiation. Here, using scRNA-sequencing of adolescent and adult mouse subcutaneous adipose tissue, the authors identify an Asc-1 positive preadipocyte population that is enriched in adolescent subcutaneous fat and demonstrate that loss of Asc-1 triggers spontaneous beige adipocyte differentiation.Lisa SuwandhiIrem AltunRuth KarlinaViktorian MiokTobias WiedemannDavid FischerThomas WalzthoeniChristina LindnerAnika BöttcherSilke S. HeinzmannAndreas IsraelAhmed Elagamy Mohamed Mahmoud KhalilAlexander BraunInes Pramme-SteinwachsIngo BurtscherPhilippe Schmitt-KopplinMatthias HeinigMartin ElsnerHeiko LickertFabian J. TheisSiegfried UssarNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lisa Suwandhi Irem Altun Ruth Karlina Viktorian Miok Tobias Wiedemann David Fischer Thomas Walzthoeni Christina Lindner Anika Böttcher Silke S. Heinzmann Andreas Israel Ahmed Elagamy Mohamed Mahmoud Khalil Alexander Braun Ines Pramme-Steinwachs Ingo Burtscher Philippe Schmitt-Kopplin Matthias Heinig Martin Elsner Heiko Lickert Fabian J. Theis Siegfried Ussar Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
description	Adipose tissue is composed of a variety of cell types, including adipocyte precursor populations, that contribute to adipose tissue function upon differentiation. Here, using scRNA-sequencing of adolescent and adult mouse subcutaneous adipose tissue, the authors identify an Asc-1 positive preadipocyte population that is enriched in adolescent subcutaneous fat and demonstrate that loss of Asc-1 triggers spontaneous beige adipocyte differentiation.
format	article
author	Lisa Suwandhi Irem Altun Ruth Karlina Viktorian Miok Tobias Wiedemann David Fischer Thomas Walzthoeni Christina Lindner Anika Böttcher Silke S. Heinzmann Andreas Israel Ahmed Elagamy Mohamed Mahmoud Khalil Alexander Braun Ines Pramme-Steinwachs Ingo Burtscher Philippe Schmitt-Kopplin Matthias Heinig Martin Elsner Heiko Lickert Fabian J. Theis Siegfried Ussar
author_facet	Lisa Suwandhi Irem Altun Ruth Karlina Viktorian Miok Tobias Wiedemann David Fischer Thomas Walzthoeni Christina Lindner Anika Böttcher Silke S. Heinzmann Andreas Israel Ahmed Elagamy Mohamed Mahmoud Khalil Alexander Braun Ines Pramme-Steinwachs Ingo Burtscher Philippe Schmitt-Kopplin Matthias Heinig Martin Elsner Heiko Lickert Fabian J. Theis Siegfried Ussar
author_sort	Lisa Suwandhi
title	Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
title_short	Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
title_full	Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
title_fullStr	Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
title_full_unstemmed	Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
title_sort	asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4238107fca564fd486a026933c82d054
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Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population

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