MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes

MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes

MicroRNAs have important roles in regulating tumor development, progression and metastasis. Here, the authors demonstrate the tumor-suppressive functions of miRNA141 in prostate cancer stem cells mediated by directly targeting CD44, Rho GTPase protein family members, and EZH2.

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Detalles Bibliográficos
Autores principales: Can Liu, Ruifang Liu, Dingxiao Zhang, Qu Deng, Bigang Liu, Hsueh-Ping Chao, Kiera Rycaj, Yoko Takata, Kevin Lin, Yue Lu, Yi Zhong, John Krolewski, Jianjun Shen, Dean G. Tang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/423923fd87f2489baee5b539e5153d24
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Descripción
Sumario:MicroRNAs have important roles in regulating tumor development, progression and metastasis. Here, the authors demonstrate the tumor-suppressive functions of miRNA141 in prostate cancer stem cells mediated by directly targeting CD44, Rho GTPase protein family members, and EZH2.

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