MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes

MicroRNAs have important roles in regulating tumor development, progression and metastasis. Here, the authors demonstrate the tumor-suppressive functions of miRNA141 in prostate cancer stem cells mediated by directly targeting CD44, Rho GTPase protein family members, and EZH2.

Guardado en:

Detalles Bibliográficos
Autores principales:	Can Liu, Ruifang Liu, Dingxiao Zhang, Qu Deng, Bigang Liu, Hsueh-Ping Chao, Kiera Rycaj, Yoko Takata, Kevin Lin, Yue Lu, Yi Zhong, John Krolewski, Jianjun Shen, Dean G. Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/423923fd87f2489baee5b539e5153d24
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:423923fd87f2489baee5b539e5153d24
record_format	dspace
spelling	oai:doaj.org-article:423923fd87f2489baee5b539e5153d242021-12-02T14:42:02ZMicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes10.1038/ncomms142702041-1723https://doaj.org/article/423923fd87f2489baee5b539e5153d242017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14270https://doaj.org/toc/2041-1723MicroRNAs have important roles in regulating tumor development, progression and metastasis. Here, the authors demonstrate the tumor-suppressive functions of miRNA141 in prostate cancer stem cells mediated by directly targeting CD44, Rho GTPase protein family members, and EZH2.Can LiuRuifang LiuDingxiao ZhangQu DengBigang LiuHsueh-Ping ChaoKiera RycajYoko TakataKevin LinYue LuYi ZhongJohn KrolewskiJianjun ShenDean G. TangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Can Liu Ruifang Liu Dingxiao Zhang Qu Deng Bigang Liu Hsueh-Ping Chao Kiera Rycaj Yoko Takata Kevin Lin Yue Lu Yi Zhong John Krolewski Jianjun Shen Dean G. Tang MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes
description	MicroRNAs have important roles in regulating tumor development, progression and metastasis. Here, the authors demonstrate the tumor-suppressive functions of miRNA141 in prostate cancer stem cells mediated by directly targeting CD44, Rho GTPase protein family members, and EZH2.
format	article
author	Can Liu Ruifang Liu Dingxiao Zhang Qu Deng Bigang Liu Hsueh-Ping Chao Kiera Rycaj Yoko Takata Kevin Lin Yue Lu Yi Zhong John Krolewski Jianjun Shen Dean G. Tang
author_facet	Can Liu Ruifang Liu Dingxiao Zhang Qu Deng Bigang Liu Hsueh-Ping Chao Kiera Rycaj Yoko Takata Kevin Lin Yue Lu Yi Zhong John Krolewski Jianjun Shen Dean G. Tang
author_sort	Can Liu
title	MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes
title_short	MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes
title_full	MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes
title_fullStr	MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes
title_full_unstemmed	MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes
title_sort	microrna-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/423923fd87f2489baee5b539e5153d24
work_keys_str_mv	AT canliu microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT ruifangliu microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT dingxiaozhang microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT qudeng microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT bigangliu microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT hsuehpingchao microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT kierarycaj microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT yokotakata microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT kevinlin microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT yuelu microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT yizhong microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT johnkrolewski microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT jianjunshen microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes AT deangtang microrna141suppressesprostatecancerstemcellsandmetastasisbytargetingacohortofprometastasisgenes
_version_	1718389804385697792

MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes

Ejemplares similares