Phosphorylation of CENP-A on serine 7 does not control centromere function

Phosphorylation of CENP-A on serine 7 does not control centromere function

Phosphorylation of CENP-A on serine 7 has been proposed to control centromere assembly and function. Here, the authors use gene targeting at both endogenous CENP-A alleles and gene replacement in human cells to demonstrate that CENP-A that cannot be phosphorylated at serine 7 maintains correct CENP-...

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Autores principales: Viviana Barra, Glennis A. Logsdon, Andrea Scelfo, Sebastian Hoffmann, Solène Hervé, Aaron Aslanian, Yael Nechemia-Arbely, Don W. Cleveland, Ben E. Black, Daniele Fachinetti
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/423a646c0dbd4210bde7daad24002f8e
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spelling oai:doaj.org-article:423a646c0dbd4210bde7daad24002f8e2021-12-02T14:35:43ZPhosphorylation of CENP-A on serine 7 does not control centromere function10.1038/s41467-018-08073-12041-1723https://doaj.org/article/423a646c0dbd4210bde7daad24002f8e2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08073-1https://doaj.org/toc/2041-1723Phosphorylation of CENP-A on serine 7 has been proposed to control centromere assembly and function. Here, the authors use gene targeting at both endogenous CENP-A alleles and gene replacement in human cells to demonstrate that CENP-A that cannot be phosphorylated at serine 7 maintains correct CENP-C recruitment, faithful chromosome segregation and long-term cell viability.Viviana BarraGlennis A. LogsdonAndrea ScelfoSebastian HoffmannSolène HervéAaron AslanianYael Nechemia-ArbelyDon W. ClevelandBen E. BlackDaniele FachinettiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Viviana Barra
Glennis A. Logsdon
Andrea Scelfo
Sebastian Hoffmann
Solène Hervé
Aaron Aslanian
Yael Nechemia-Arbely
Don W. Cleveland
Ben E. Black
Daniele Fachinetti
Phosphorylation of CENP-A on serine 7 does not control centromere function
description Phosphorylation of CENP-A on serine 7 has been proposed to control centromere assembly and function. Here, the authors use gene targeting at both endogenous CENP-A alleles and gene replacement in human cells to demonstrate that CENP-A that cannot be phosphorylated at serine 7 maintains correct CENP-C recruitment, faithful chromosome segregation and long-term cell viability.
format article
author Viviana Barra
Glennis A. Logsdon
Andrea Scelfo
Sebastian Hoffmann
Solène Hervé
Aaron Aslanian
Yael Nechemia-Arbely
Don W. Cleveland
Ben E. Black
Daniele Fachinetti
author_facet Viviana Barra
Glennis A. Logsdon
Andrea Scelfo
Sebastian Hoffmann
Solène Hervé
Aaron Aslanian
Yael Nechemia-Arbely
Don W. Cleveland
Ben E. Black
Daniele Fachinetti
author_sort Viviana Barra
title Phosphorylation of CENP-A on serine 7 does not control centromere function
title_short Phosphorylation of CENP-A on serine 7 does not control centromere function
title_full Phosphorylation of CENP-A on serine 7 does not control centromere function
title_fullStr Phosphorylation of CENP-A on serine 7 does not control centromere function
title_full_unstemmed Phosphorylation of CENP-A on serine 7 does not control centromere function
title_sort phosphorylation of cenp-a on serine 7 does not control centromere function
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/423a646c0dbd4210bde7daad24002f8e
work_keys_str_mv AT vivianabarra phosphorylationofcenpaonserine7doesnotcontrolcentromerefunction
AT glennisalogsdon phosphorylationofcenpaonserine7doesnotcontrolcentromerefunction
AT andreascelfo phosphorylationofcenpaonserine7doesnotcontrolcentromerefunction
AT sebastianhoffmann phosphorylationofcenpaonserine7doesnotcontrolcentromerefunction
AT soleneherve phosphorylationofcenpaonserine7doesnotcontrolcentromerefunction
AT aaronaslanian phosphorylationofcenpaonserine7doesnotcontrolcentromerefunction
AT yaelnechemiaarbely phosphorylationofcenpaonserine7doesnotcontrolcentromerefunction
AT donwcleveland phosphorylationofcenpaonserine7doesnotcontrolcentromerefunction
AT beneblack phosphorylationofcenpaonserine7doesnotcontrolcentromerefunction
AT danielefachinetti phosphorylationofcenpaonserine7doesnotcontrolcentromerefunction
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