Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells.

Gold nanoparticles (AuNPs) hold great promise in nanomedicine, yet their successful clinical translation has not been realized. Some challenges include effective AuNP targeting and delivery to improve modulation of immune cells of interest while limiting potential adverse effects. In order to overco...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ingrid Safina, Zeid A Nima Al Sudani, Ahmed Hashoosh, Emilie Darrigues, Fumiya Watanabe, Alexandru S Biris, Ruud P M Dings, Kieng Bao Vang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/423c529f5edd45eb82c80b5d403ec05d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:423c529f5edd45eb82c80b5d403ec05d
record_format	dspace
spelling	oai:doaj.org-article:423c529f5edd45eb82c80b5d403ec05d2021-12-02T20:14:53ZGold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells.1932-620310.1371/journal.pone.0241882https://doaj.org/article/423c529f5edd45eb82c80b5d403ec05d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0241882https://doaj.org/toc/1932-6203Gold nanoparticles (AuNPs) hold great promise in nanomedicine, yet their successful clinical translation has not been realized. Some challenges include effective AuNP targeting and delivery to improve modulation of immune cells of interest while limiting potential adverse effects. In order to overcome these challenges, we must fully understand how AuNPs impact different immune cell subsets, particularly within the dendritic cell and T cell compartments. Herein, we show that polyethylene glycol coated (PEG) gold nanorods (AuNRs) and PEG AuNRs covered with a thin layer of silver (AuNR/Ag) may enhance the immune response towards immune suppression or activation. We also studied the ability to enhance CD4+ Foxp3+ Tregs in vitro using AuNRs functionalized with interleukin 2 (IL2), a cytokine that is important in Treg development and homeostasis. Our results indicate that AuNRs enhance different immune cells and that NP composition matters in immune targeting. This knowledge will help us understand how to better design AuNRs to target and enhance the immune system.Ingrid SafinaZeid A Nima Al SudaniAhmed HashooshEmilie DarriguesFumiya WatanabeAlexandru S BirisRuud P M DingsKieng Bao VangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0241882 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ingrid Safina Zeid A Nima Al Sudani Ahmed Hashoosh Emilie Darrigues Fumiya Watanabe Alexandru S Biris Ruud P M Dings Kieng Bao Vang Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells.
description	Gold nanoparticles (AuNPs) hold great promise in nanomedicine, yet their successful clinical translation has not been realized. Some challenges include effective AuNP targeting and delivery to improve modulation of immune cells of interest while limiting potential adverse effects. In order to overcome these challenges, we must fully understand how AuNPs impact different immune cell subsets, particularly within the dendritic cell and T cell compartments. Herein, we show that polyethylene glycol coated (PEG) gold nanorods (AuNRs) and PEG AuNRs covered with a thin layer of silver (AuNR/Ag) may enhance the immune response towards immune suppression or activation. We also studied the ability to enhance CD4+ Foxp3+ Tregs in vitro using AuNRs functionalized with interleukin 2 (IL2), a cytokine that is important in Treg development and homeostasis. Our results indicate that AuNRs enhance different immune cells and that NP composition matters in immune targeting. This knowledge will help us understand how to better design AuNRs to target and enhance the immune system.
format	article
author	Ingrid Safina Zeid A Nima Al Sudani Ahmed Hashoosh Emilie Darrigues Fumiya Watanabe Alexandru S Biris Ruud P M Dings Kieng Bao Vang
author_facet	Ingrid Safina Zeid A Nima Al Sudani Ahmed Hashoosh Emilie Darrigues Fumiya Watanabe Alexandru S Biris Ruud P M Dings Kieng Bao Vang
author_sort	Ingrid Safina
title	Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells.
title_short	Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells.
title_full	Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells.
title_fullStr	Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells.
title_full_unstemmed	Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells.
title_sort	gold nanorods enhance different immune cells and allow for efficient targeting of cd4+ foxp3+ tregulatory cells.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/423c529f5edd45eb82c80b5d403ec05d
work_keys_str_mv	AT ingridsafina goldnanorodsenhancedifferentimmunecellsandallowforefficienttargetingofcd4foxp3tregulatorycells AT zeidanimaalsudani goldnanorodsenhancedifferentimmunecellsandallowforefficienttargetingofcd4foxp3tregulatorycells AT ahmedhashoosh goldnanorodsenhancedifferentimmunecellsandallowforefficienttargetingofcd4foxp3tregulatorycells AT emiliedarrigues goldnanorodsenhancedifferentimmunecellsandallowforefficienttargetingofcd4foxp3tregulatorycells AT fumiyawatanabe goldnanorodsenhancedifferentimmunecellsandallowforefficienttargetingofcd4foxp3tregulatorycells AT alexandrusbiris goldnanorodsenhancedifferentimmunecellsandallowforefficienttargetingofcd4foxp3tregulatorycells AT ruudpmdings goldnanorodsenhancedifferentimmunecellsandallowforefficienttargetingofcd4foxp3tregulatorycells AT kiengbaovang goldnanorodsenhancedifferentimmunecellsandallowforefficienttargetingofcd4foxp3tregulatorycells
_version_	1718374639858614272

Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells.

Ejemplares similares