CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression

Ectonucleotidases associated to regulatory T cells are known modulators in the inflammatory environment. Here the authors describe CD8 T cell-derived extracellular vesicles bearing CD73 and suggest they function as an additional intrinsic modulator of immune responses.

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Autores principales:	Enja Schneider, Riekje Winzer, Anne Rissiek, Isabell Ricklefs, Catherine Meyer-Schwesinger, Franz L. Ricklefs, Andreas Bauche, Jochen Behrends, Rudolph Reimer, Santra Brenna, Hauke Wasielewski, Melchior Lauten, Björn Rissiek, Berta Puig, Filippo Cortesi, Tim Magnus, Ralf Fliegert, Christa E. Müller, Nicola Gagliani, Eva Tolosa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/423c6b103e9d4f51bf3e93a6880c1a59
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spelling	oai:doaj.org-article:423c6b103e9d4f51bf3e93a6880c1a592021-12-02T18:01:42ZCD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression10.1038/s41467-021-26134-w2041-1723https://doaj.org/article/423c6b103e9d4f51bf3e93a6880c1a592021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26134-whttps://doaj.org/toc/2041-1723Ectonucleotidases associated to regulatory T cells are known modulators in the inflammatory environment. Here the authors describe CD8 T cell-derived extracellular vesicles bearing CD73 and suggest they function as an additional intrinsic modulator of immune responses.Enja SchneiderRiekje WinzerAnne RissiekIsabell RicklefsCatherine Meyer-SchwesingerFranz L. RicklefsAndreas BaucheJochen BehrendsRudolph ReimerSantra BrennaHauke WasielewskiMelchior LautenBjörn RissiekBerta PuigFilippo CortesiTim MagnusRalf FliegertChrista E. MüllerNicola GaglianiEva TolosaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Enja Schneider Riekje Winzer Anne Rissiek Isabell Ricklefs Catherine Meyer-Schwesinger Franz L. Ricklefs Andreas Bauche Jochen Behrends Rudolph Reimer Santra Brenna Hauke Wasielewski Melchior Lauten Björn Rissiek Berta Puig Filippo Cortesi Tim Magnus Ralf Fliegert Christa E. Müller Nicola Gagliani Eva Tolosa CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
description	Ectonucleotidases associated to regulatory T cells are known modulators in the inflammatory environment. Here the authors describe CD8 T cell-derived extracellular vesicles bearing CD73 and suggest they function as an additional intrinsic modulator of immune responses.
format	article
author	Enja Schneider Riekje Winzer Anne Rissiek Isabell Ricklefs Catherine Meyer-Schwesinger Franz L. Ricklefs Andreas Bauche Jochen Behrends Rudolph Reimer Santra Brenna Hauke Wasielewski Melchior Lauten Björn Rissiek Berta Puig Filippo Cortesi Tim Magnus Ralf Fliegert Christa E. Müller Nicola Gagliani Eva Tolosa
author_facet	Enja Schneider Riekje Winzer Anne Rissiek Isabell Ricklefs Catherine Meyer-Schwesinger Franz L. Ricklefs Andreas Bauche Jochen Behrends Rudolph Reimer Santra Brenna Hauke Wasielewski Melchior Lauten Björn Rissiek Berta Puig Filippo Cortesi Tim Magnus Ralf Fliegert Christa E. Müller Nicola Gagliani Eva Tolosa
author_sort	Enja Schneider
title	CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
title_short	CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
title_full	CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
title_fullStr	CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
title_full_unstemmed	CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
title_sort	cd73-mediated adenosine production by cd8 t cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/423c6b103e9d4f51bf3e93a6880c1a59
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CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression

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