Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification

The biosynthesis of xiamycin, an antimicrobial bacterial indolosesquiterpenoid, involves an unusual cyclization cascade. Here, the authors characterise the XiaF enzyme, which resembles xenobiont-degrading enzymes and is responsible for a hidden indole hydroxylation step that triggers the cyclization...

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Autores principales:	Susann Kugel, Martin Baunach, Philipp Baer, Mie Ishida-Ito, Srividhya Sundaram, Zhongli Xu, Michael Groll, Christian Hertweck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/423ff068b16c45a78cc7b351d616621f
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spelling	oai:doaj.org-article:423ff068b16c45a78cc7b351d616621f2021-12-02T17:06:12ZCryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification10.1038/ncomms158042041-1723https://doaj.org/article/423ff068b16c45a78cc7b351d616621f2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15804https://doaj.org/toc/2041-1723The biosynthesis of xiamycin, an antimicrobial bacterial indolosesquiterpenoid, involves an unusual cyclization cascade. Here, the authors characterise the XiaF enzyme, which resembles xenobiont-degrading enzymes and is responsible for a hidden indole hydroxylation step that triggers the cyclization reaction.Susann KugelMartin BaunachPhilipp BaerMie Ishida-ItoSrividhya SundaramZhongli XuMichael GrollChristian HertweckNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Susann Kugel Martin Baunach Philipp Baer Mie Ishida-Ito Srividhya Sundaram Zhongli Xu Michael Groll Christian Hertweck Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification
description	The biosynthesis of xiamycin, an antimicrobial bacterial indolosesquiterpenoid, involves an unusual cyclization cascade. Here, the authors characterise the XiaF enzyme, which resembles xenobiont-degrading enzymes and is responsible for a hidden indole hydroxylation step that triggers the cyclization reaction.
format	article
author	Susann Kugel Martin Baunach Philipp Baer Mie Ishida-Ito Srividhya Sundaram Zhongli Xu Michael Groll Christian Hertweck
author_facet	Susann Kugel Martin Baunach Philipp Baer Mie Ishida-Ito Srividhya Sundaram Zhongli Xu Michael Groll Christian Hertweck
author_sort	Susann Kugel
title	Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification
title_short	Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification
title_full	Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification
title_fullStr	Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification
title_full_unstemmed	Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification
title_sort	cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/423ff068b16c45a78cc7b351d616621f
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Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification

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